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Source: Journal of Stroke and Cerebrovascular Diseases
Condition: Thrombosis
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Total 415 results found since Jan 2013.
Giant Vertebrobasilar Fusiform Aneurysm Mass Effect Heralds Rapid in Situ Thrombosis and Ischemic Stroke in the Setting of Ulcerative Colitis
Here we describe a case of brainstem infarction secondary to rapid thrombus formation in a giant vertebrobasilar fusiform aneurysm (GVBFA) that was preceded clinically by several months of headaches and dizziness initially attributable to mass effect. Less than a month after initial identification of the aneurysm, a large partially-occluding thrombus formed leading to infarction of the brainstem. Interestingly, this patient also had ulcerative colitis, which has been associated with acquired hypercoagulability.
Source: Journal of Stroke and Cerebrovascular Diseases - February 10, 2021 Category: Neurology Authors: Keith J. Kincaid, Ju Yu, Franklin D. Echevarria, Alexis N. Simpkins Tags: Case Report Source Type: research
Changes in Procoagulant Blood Biomarkers After Mechanical Thrombectomy
We report changes in blood coagulation markers after MT treated with and without tissue plasminogen activator for AIS.
Source: Journal of Stroke and Cerebrovascular Diseases - April 8, 2021 Category: Neurology Authors: Jonathan C. Welch, Kadir Erkmen, Nina Gentile Source Type: research
Platelet Function Monitoring Performed after Carotid Stenting during Endovascular Stroke Treatment Predicts Outcome
Antiplatelets agents are widely used and effective for secondary prevention of vascular diseases. Some patients might have reduced platelet inhibition on antiplatelet therapy with a higher risk of ischemic complications.1,2 The role of platelet function monitoring (PFM) has been extensively investigated in cardiology. Resistance to Clopidogrel correlates with higher risk of long-term cardiovascular events and coronary stent thrombosis.3,4 Similarly, studies performed after elective carotid stenting showed that ischemic recurrence and early stent thrombosis are more common in non-responders to Clopidogrel.
Source: Journal of Stroke and Cerebrovascular Diseases - May 5, 2021 Category: Neurology Authors: Ludovico Ciolli, Nicoletta Lelli, Francesca Rosafio, Stefania Maffei, Federico Sacchetti, Laura Vandelli, Maria Luisa Dell'Acqua, Livio Picchetto, Giuseppe Maria Borz ì, Riccardo Ricceri, Roberta Pentore, Manuela Tondelli, Gabriele Vandelli, Noelia Rodr Source Type: research
Glasgow Coma Scale ≤ 12 at Admission is a Predictor of Poor Functional Outcome (mRS 2–6) at One Year in Patients with Cerebral Venous Thrombosis
Cerebral venous thrombosis (CVT) is a relatively uncommon cause of stroke with reported annual incidence of 0.2 –1.57 per hundred thousand population.1 Although the exact incidence of the disease in India is not known it is believed to be more common than western population especially in the young. It may occur in as much as 15–20% of all strokes occurring in age less than 40 years.2 The mean age in a lar ge series from India was around 30 years.3 Over the last few decades, the mortality rates of CVT have declined to around 4–5% due to improved diagnostic imaging, better therapeutics, and hospital care.
Source: Journal of Stroke and Cerebrovascular Diseases - April 26, 2021 Category: Neurology Authors: Salil Gupta, Rahul Soni, Pawan Dhull, Manoj Somasekharan, Amit Sreen Source Type: research
Treatment of ChAdOx1 nCoV-19 Vaccine-Induced Immune Thrombotic Thrombocytopenia Related Acute Ischemic Stroke
We report clinical, laboratory, imaging findings and treatment in a 51-year-old female presenting with acute left middle cerebral artery (MCA) occlusion 7 days after the first dose of ChAdOx1 nCoV-19 vaccine.
Source: Journal of Stroke and Cerebrovascular Diseases - August 28, 2021 Category: Neurology Authors: Jana Kenda, Dimitrij Lovri č, Matevž Škerget, Nataša Milivojević Tags: Short Communication Source Type: research
Downregulation of NF- κB by Shp-1 Alleviates Cerebral Venous Sinus Thrombosis-Induced Brain Edema Via Suppression of AQP4
Aquaporin 4 (AQP4), a water channel protein, has been well studied in arterial stroke-induced brain edema. However, the role of AQP4 in cerebral venous sinus thrombosis (CVST) has not been reported. Here, we showed that AQP4 expression was increased in the brain of a rat CVST model, whereas inhibition of AQP4 decreased cerebral edema. Subsequent experiments showed that Shp-1 (Src homology 2-containing phosphatase-1) expression and NF- κB phosphorylation were upregulated after CVST. We found that Shp-1 inhibition resulted in enhancement of NF-κB activation and increased AQP4 expression accompanied by aggravated brain edema.
Source: Journal of Stroke and Cerebrovascular Diseases - May 26, 2022 Category: Neurology Authors: Baiqiang Chen, Xiangyi Kong, Zhuo Li, Wenjie Hu, Han Zhou, Jingchen Gao, Yu Cui, Shifang Li, Qi Wan, Yugong Feng Source Type: research
Early high-dose intravenous immunoglobulin for refractory heparin-induced thrombocytopenia with stroke: Two case reports
Heparin-induced thrombocytopenia (HIT) is a drug reaction caused by anti-platelet factor 4 (PF4)/heparin antibodies of the IgG class that activate through Fc γ receptors on platelets and monocytes. They consume platelets and increase thrombin generation.1 HIT occurs 5 to 14 days after the start of heparinization.2 Management of HIT involves discontinuing heparin and switching to an alternative anticoagulant to prevent thrombosis and normalize platelet l evels.3–5 Autoimmune HIT (aHIT), which maintains marked heparin-independent platelet activation even after discontinuing heparin, has recently attracted attention.
Source: Journal of Stroke and Cerebrovascular Diseases - January 24, 2023 Category: Neurology Authors: Naoki Makita, Tomoyuki Ohara, Yukiko Tsuji, Tetsuhiro Ueda, Takuma Nakamura, Toshiki Mizuno, Masahiro Makino Tags: Case Report Source Type: research
Blood group and ischemic stroke, myocardial infarction, and peripheral vascular disease: A meta-analysis of over 145,000 cases and 2,000,000 controls
The ABO blood groups have been associated with the pathophysiology of cardiovascular diseases through an influence on two important blood clotting proteins, von Willebrand factor (vWF) and factor FVIII levels (FVIII).1,2 These proteins circulate in the plasma as a complex and are vital in normal haemostasis.1 The highest levels of FVIII and VWF are seen in non-O blood groups. Studies suggest a relationship between non-O blood groups and an increased risk of venous thromboembolism and other thrombotic episodes.
Source: Journal of Stroke and Cerebrovascular Diseases - June 18, 2023 Category: Neurology Authors: Zornitsa Lilova, Faiza Hassan, Malaika Riaz, Joshua Ironside, Gie Ken-Dror, Thang Han, Pankaj Sharma Source Type: research
Factors influencing real-life use of direct oral anticoagulants in patients with cerebral sinus and venous thrombosis
Cerebral sinus and venous thrombosis (CSVT) is a rare subtype of stroke caused by thrombosis of the dural sinuses and cerebral veins which comprises 0.5 –1% of all strokes1,2. The annual incidence ranges from 0.22 to 1.57 per 100,000, most often affecting young adults with a median age of 35 years3-5. Among CSVT patients, the female-to-male ratio is 3:1 and women are significantly younger compared to men6. This is largely due to the increased risk of CSVT associated with oral contraceptives, pregnancy and the puerperium3,7,8.
Source: Journal of Stroke and Cerebrovascular Diseases - July 10, 2023 Category: Neurology Authors: Naaem Simaan, Jeremy Molad, Asaf Honig, Andrei Filioglo, Shlomi Peretz, Fadi Shbat, Tarek Mansor, Waleed Abu-shaheen, Ronen R. Leker Source Type: research
In-stent Thrombosis after Carotid Artery Stenting Despite Sufficient Antiplatelet Therapy in a Bladder Cancer Patient
We present a case of early IST after CAS despite sufficient antiplatelet therapy in a patient with bladder cancer. A 77-year-old man under preventive triple antiplatelet therapy underwent CAS without any intra- or periprocedural complications. However, the patient developed a large asymptomatic IST 6 days after CAS. Anticoagulant therapy with argatroban was reintroduced to treat IST concomitant with antiplatelet agents. Subsequently, the IST shrank and disappeared without any thrombotic symptoms. Malignancy is regarded as an acquired thrombophilic condition associated with a significant risk of thrombosis. In the field of ...
Source: Journal of Stroke and Cerebrovascular Diseases - July 8, 2013 Category: Neurology Authors: Kazuya Kanemaru, Yoshihisa Nishiyama, Hideyuki Yoshioka, Kaneo Satoh, Koji Hashimoto, Mitsuto Hanihara, Toru Horikoshi, Yukio Ozaki, Hiroyuki Kinouchi Tags: Case Reports Source Type: research
Thrombosis of a Developmental Venous Anomaly in Inflammatory Bowel Disease: Case Report and Radiologic Follow-up
We describe the clinical and neuroradiologic follow-up of a 62-year-old man with a history of inflammatory bowel disease (IBD) presenting with new onset epilepsy and intracranial hemorrhage caused by thrombosis of a DVA who fully recovered after treatment with oral anticoagulant therapy. Patients with IBD have an increased risk of thrombosis because of inflammatory activity and the hypercoagulable state. Here we describe the first case of DVA thrombosis in a patient with IBD, and we show clinical and neuroradiologic follow-up after anticoagulant therapy.
Source: Journal of Stroke and Cerebrovascular Diseases - January 3, 2013 Category: Neurology Authors: Fabio Pilato, Rosalinda Calandrelli, Simona Gaudino, Paolo Profice, Matia Martucci, Giuseppe Esposito, Cesare Colosimo, Vincenzo Di Lazzaro Tags: Case Reports Source Type: research
Clinical and Radiological Management and Outcome of Pregnancies Complicated by Cerebral Venous Thrombosis: A Review of 19 Cases
Conclusions: If magnetic resonance imaging is available, it should be used for the detection of CVT in all pregnant patients instead of computed tomography. Patients with parenchymal lesions, thrombophilia, and antiphospholipid syndrome had a greater risk of being left with neurologic sequelae. For pregnant patients with CVT, low molecular weight heparin in full anticoagulant doses should be continued throughout the pregnancy. Anticoagulant therapy did not appear to predispose patients to further intracranial hemorrhage.
Source: Journal of Stroke and Cerebrovascular Diseases - August 17, 2012 Category: Neurology Authors: Caner Feyzi Demir, Mehmet Fatih İnci, Fuat Özkan, Mustafa Yıldız, Hasan Özdemir Tags: Original Articles Source Type: research
Thrombosis of a Developmental Venous Anomaly Causing Venous Infarction and Pontine Hemorrhage
We report a case of a thrombosed developmental venous anomaly with venous congestion and pontine hemorrhage that improved after anticoagulation therapy.
Source: Journal of Stroke and Cerebrovascular Diseases - June 21, 2013 Category: Neurology Authors: Dayna Griffiths, Allison Newey, Kenneth Faulder, Brendan Steinfort, Martin Krause Tags: Case Reports Source Type: research
Successful Treatment of Cerebral Venous Thrombosis Associated with Ulcerative Colitis
Thromboembolic complications, such as deep venous thrombosis and pulmonary embolism, are well described in patients with inflammatory bowel disease, but cerebral venous thrombosis (CVT) is a rare but potentially devastating complication. The authors describe the case of a 36-year-old Japanese man presenting with CVT associated with ulcerative colitis (UC) that was successfully treated with a combination of continuous anticoagulant and pulse steroid therapy. Our observations suggest that aggressive therapy for inducing acute UC remission is vitally important for CVT associated with UC.
Source: Journal of Stroke and Cerebrovascular Diseases - August 12, 2013 Category: Neurology Authors: Satoshi Suda, Ken-ichiro Katsura, Seiji Okubo, Arata Abe, Kentaro Suzuki, Masanori Suzuki, Yasuo Katayama Tags: Case Reports Source Type: research
MRI-guided Sonothrombolysis of Rabbit Carotid Artery
The potential of magnetic resonance imaging–guided focused ultrasound (MRgFUS) combined with the thrombolytic drug recombinant tissue plasminogen activator (rt-PA) to dissolve clots in the carotid of a New Zealand rabbit in vivo is evaluated. A spherically focused transducer of 5-cm diameter, focusing at 10 cm and operating at 1 MHz, was used. A pulsed ultrasound protocol was used that maintains a tissue temperature increase of less than 1°C in the clot (called safe temperature). MRgFUS has the potentials to dissolve clots that are injected in the carotid of rabbits in vivo. It was found that the time needed for ope...
Source: Journal of Stroke and Cerebrovascular Diseases - October 14, 2013 Category: Neurology Authors: Christakis Damianou, Venediktos Hadjisavvas, Nicos Mylonas, Andreas Couppis, Kleanthis Ioannides Tags: Original Articles Source Type: research
