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A new strategy for anticoagulation: The factor XI inhibitors
Eur J Intern Med. 2023 Aug 4:S0953-6205(23)00284-4. doi: 10.1016/j.ejim.2023.08.001. Online ahead of print.ABSTRACTDirect oral anticoagulants (DOACs) are currently the first-choice therapy for the prevention of cardioembolic events in patients with atrial fibrillation and for the treatment of venous thromboembolism (VTE) due to their more favorable efficacy to safety profile in comparison to vitamin K antagonists (VKA). DOACs did not show a clinical benefit when used for in stroke prevention in patients with mechanic or rheumatic valves or in those who underwent transcatheter aortic valve implantation (TAVI), in the treatm...
Source: European Journal of Internal Medicine - August 6, 2023 Category: Internal Medicine Authors: Maria Cristina Vedovati Cecilia Becattini Giancarlo Agnelli Source Type: research

Effect of extended duration of thromboprophylaxis for medically ill patients
CONCLUSIONS: Extended thromboprophylaxis, especially with LMWH, showed better efficacy in venous thromboembolism reduction with increased risk of major bleeding. The beneficial effect of LMWH with extended timing has also been shown in stroke patients. Overall, extended thromboprophylaxis is associated with a positive net clinical benefit.PMID:37029050 | DOI:10.1016/j.ejim.2023.03.032
Source: European Journal of Internal Medicine - April 7, 2023 Category: Internal Medicine Authors: Xing Wang Yuqi Chen Dingke Wen Chao You Lu Ma Source Type: research

Mobile health-technology integrated care in atrial fibrillation patients with heart failure: A report from the mAFA-II randomized clinical trial
CONCLUSION: A mHealth-technology implemented ABC pathway provides consistent effects on the risks of primary outcome, rehospitalisation and bleeding, in AF patients both with and without HF. However, AF-HF patients may need tailored approaches to improve their overall prognosis, specifically to reduce the risk of recurrent AF, HF and acute coronary syndrome.PMID:36347740 | DOI:10.1016/j.ejim.2022.11.002
Source: European Journal of Internal Medicine - November 8, 2022 Category: Internal Medicine Authors: Yutao Guo Giulio Francesco Romiti Bernadette Corica Marco Proietti Niccol ò Bonini Hui Zhang Gregory Yh Lip mAF-App II trial investigators Source Type: research

Evolving concepts in the management of antithrombotic therapy in patients undergoing transcatheter aortic valve implantation
Eur J Intern Med. 2022 May 24:S0953-6205(22)00171-6. doi: 10.1016/j.ejim.2022.05.002. Online ahead of print.ABSTRACTThromboembolic and bleeding complications negatively impact recovery and survival after transcatheter aortic valve implantation (TAVI). Particularly, there is a considerable risk of ischaemic stroke and vascular access related bleeding, as well as spontaneous gastro-intestinal bleeding. Therefore, benefit and harm of antithrombotic therapy should be carefully balanced. This review summarizes current evidence on peri- and post-procedural antithrombotic treatment. Indeed, in recent years, the management of anti...
Source: European Journal of Internal Medicine - May 27, 2022 Category: Internal Medicine Authors: Dirk Jan van Ginkel Willem L Bor Leo Veenstra Arnoud W J van 't Hof Enrico Fabris Source Type: research

Thrombotic events following Covid-19 vaccines compared to Influenza vaccines
CONCLUSIONS AND RELEVANCE: This study shows a significant increase in thrombotic events in subjects vaccinated with Covid-19 vaccines in comparison to a control group. The clinical implication of these findings should be interpreted with caution, in light of the high effectiveness of vaccination and the inherent risk of thrombosis from Covid-19 infection itself.PMID:35288031 | DOI:10.1016/j.ejim.2022.03.002
Source: European Journal of Internal Medicine - March 15, 2022 Category: Internal Medicine Authors: Marcelo Gabriel Vallone Andre Luis Falc ón Horacio Matias Castro Augusto Ferraris Ramiro Francisco Cantarella Mar ía Inés Staneloni Valeria Ines Aliperti Analia Ferloni Daniela Mezzarobba Fernando Javier V ázquez Mar ía Florencia Grande Ratti Source Type: research

Extended venous thromboprophylaxis in patients hospitalized for acute ischemic stroke: A systematic review and meta-analysis
CONCLUSION: In patients hospitalized for acute ischemic stroke, the net clinical benefit may favor extended venous thromboprophylaxis for four to five weeks over standard thromboprophylaxis.PMID:34649783 | DOI:10.1016/j.ejim.2021.09.016
Source: European Journal of Internal Medicine - October 15, 2021 Category: Internal Medicine Authors: Emanuele Valeriani Nicola Potere Matteo Candeloro Silvia Spoto Ettore Porreca Anne Ws Rutjes Marcello Di Nisio Source Type: research

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