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Biosimilar tenecteplase versus alteplase in acute ischemic stroke: A real world study
Conclusion: This present study observed no difference in the efficacy and safety between biosimilar TNK and rTPA. Our findings are in concordance with published trials showing equivalence between the two molecules.
Source: Annals of Indian Academy of Neurology - January 25, 2023 Category: Neurology Authors: Ayush Mohan Snigdha Komakula Suhas Murali Pooja Anand Dyuti Shah VY Vishnu Awadh Kishor Pandit Ayush Agarwal Deepti Vibha Mamta Bhushan Singh MV Padma Srivastava Rohit Bhatia Source Type: research

Gut microbiota dysbiosis in patients with intracranial sino-venous thrombosis and acute ischemic stroke in the young
Varsha A Prabhu, Vinay Rajput, Rakeshkumar Yadav, Kushal Gohil, Mahesh S Dharne, Mazhuvancherry Kesavan Unnikrishnan, Sankar Prasad GorthiAnnals of Indian Academy of Neurology 2022 25(5):980-983
Source: Annals of Indian Academy of Neurology - October 31, 2022 Category: Neurology Authors: Varsha A Prabhu Vinay Rajput Rakeshkumar Yadav Kushal Gohil Mahesh S Dharne Mazhuvancherry Kesavan Unnikrishnan Sankar Prasad Gorthi Source Type: research

Propensity of stroke in standard versus various aortic arch variants: A 200 patients study
Conclusions: Standard aortic arch Type 2, bovine aortic arch Type A, and Type B are associated with an early age at stroke presentation. During routine carotid evaluation by CT or MR angiography in stroke patients, it would be better to evaluate the aortic arch as well, especially in young patients.
Source: Annals of Indian Academy of Neurology - September 9, 2022 Category: Neurology Authors: Swapnil Samadhiya Vijay Sardana Bharat Bhushan Dilip Maheshwari Seeta Ram Yadav Ravi Goyal Source Type: research

Acute ischemic stroke in children & #8211; should we thrombolyze ?
KP Vinayan, Vivek Nambiar, Vaishakh AnandAnnals of Indian Academy of Neurology 2022 25(1):21-25 Ischemic stroke is a major cause of acute neurological symptoms in children with significant long-term neurological sequelae. Unlike in the adult population, the clinical presentation of strokes in children may not be stereotyped. Hence, many other differential diagnostic possibilities might have to be considered in the emergency setting. Due to this heterogeneous presentation and the resultant clinical dilemma in the early detection, acute thrombolysis even now remains as a very rarely tried therapeutic option in children. Man...
Source: Annals of Indian Academy of Neurology - February 22, 2022 Category: Neurology Authors: KP Vinayan Vivek Nambiar Vaishakh Anand Source Type: research

Predisposing factors and management of hemodynamic depression following carotid artery stenting
Pachipala Sudheer, Ayush Agarwal, Venugopalan Y Vishnu, MV Padma SrivastavaAnnals of Indian Academy of Neurology 2021 24(3):315-318 Carotid artery stenting (CAS) involves dilatation of carotid bulb which can trigger a series of neuronal responses resulting in hemodynamic depression that might influence the outcome of the procedure. This is a frequent but underdiagnosed complication of CAS. Although it is mild, transient and self-limiting in majority of cases, it can result in significant morbidity and mortality if persistent. Neurologists should be aware of the predisposing factors and management of this common complicati...
Source: Annals of Indian Academy of Neurology - July 17, 2021 Category: Neurology Authors: Pachipala Sudheer Ayush Agarwal Venugopalan Y Vishnu MV Padma Srivastava Source Type: research

Selective hand motor cortex lesions masquerading as & #8220;Pseudoperipheral Nerve Palsy & #8221;
Bhaskara P Shelley, Prakash Harishchandra, Acharya K DevadasAnnals of Indian Academy of Neurology 2020 23(5):688-693 Strategic cortical lesions involving the hand motor cortex (HMC) presenting acutely as distal upper limb pure motor weakness certainly do need to be differentiated on clinical grounds from “pseudoperipheral palsy.” This rare phenotype can imitate peripheral motor nerve deficits and should not be easily overlooked. The? isolated “central hand and finger weakness” presenting as an acute onset of varying combinations such as pseudomedian, pseudoradial,...
Source: Annals of Indian Academy of Neurology - December 8, 2020 Category: Neurology Authors: Bhaskara P Shelley Prakash Harishchandra Acharya K Devadas Source Type: research

Depression and quality of life after cerebral venous sinus thrombosis
Conclusion: This is the first Indian study demonstrating depression in patients with CVST and use of SA-SIP to assess quality of life in them. Occurrence of depression in CVST is as high as in arterial strokes.
Source: Annals of Indian Academy of Neurology - August 20, 2020 Category: Neurology Authors: Aralikatte O Saroja Ninad N Thorat Karkal R Naik Source Type: research

Innovations in acute stroke reperfusion strategies
Venugopalan Y Vishnu, MV Padma SrivastavaAnnals of Indian Academy of Neurology 2019 22(1):6-12 Vascular neurology is witnessing unprecedented innovations in the management of acute ischemic stroke, especially in reperfusion strategies. The emergence of mechanical thrombectomy with new generation devices has revolutionized the treatment of acute ischemic stroke with large vessel occlusion. The reperfusion strategies are evolving with the extension of the window period for thrombolysis and endovascular therapy through the concept of “tissue clock” in addition to the established “time c...
Source: Annals of Indian Academy of Neurology - December 26, 2018 Category: Neurology Authors: Venugopalan Y Vishnu MV Padma Srivastava Source Type: research

A hospital-based study of stroke in young from North East India
Conclusion: Although traditional risk factors are associated with stroke in young, unfavorable behavioral pattern such as alcohol abuse may cause and promote development stroke in young.
Source: Annals of Indian Academy of Neurology - September 4, 2018 Category: Neurology Authors: Masaraf Hussain Shri Ram Sharma MD Jamil Source Type: research

Clinical presentation, neuroimaging findings, and predictors of brain parenchymal lesions in cerebral vein and dural sinus thrombosis: A retrospective study
Conclusion: CVST presents in young and more commonly in females. TS was the most common site of venous sinus thrombosis. Female gender, seizures, altered sensorium and focal neurological deficit at presentation, and straight sinus thrombosis were more likely associated with the presence of brain parenchymal lesions.
Source: Annals of Indian Academy of Neurology - September 4, 2018 Category: Neurology Authors: Gourav Goyal Abhishek Charan Rambir Singh Source Type: research

Hemorrhagic stroke and cerebral venous thrombosis: rare neurological sequelae of chickenpox infection
Anuradha Mehta, Aanchal Arora, Manoj Sharma, Rupali Malik, Yogesh Chandra PorwalAnnals of Indian Academy of Neurology 2018 21(3):228-232 Chickenpox (varicella) is primarily a disease of childhood which occurs due to infection with varicella-zoster virus (VZV). Primary VZV infection is rare in adults due to exposure in early childhood in our country. In adults, it is associated with some serious systemic and neurological complications which can follow both primary infection and reactivation of VZV. Neurological sequelae caused by primary VZV infection are rare and include encephalitis, aseptic meningitis, myelitis, acute c...
Source: Annals of Indian Academy of Neurology - September 4, 2018 Category: Neurology Authors: Anuradha Mehta Aanchal Arora Manoj Sharma Rupali Malik Yogesh Chandra Porwal Source Type: research

Factors influencing nonadministration of thrombolytic therapy in early arrival strokes in a university hospital in Hyderabad, India
Conclusion: One-fourth of early ischemic stroke patients in our study were not thrombolyzed even though they arrived within the window period. The majority of the reasons for nonadministration of thrombolysis were potentially preventable, such as nonaffordability, intrahospital delay, and nonavailability of newer endovascular interventions.
Source: Annals of Indian Academy of Neurology - July 24, 2016 Category: Neurology Authors: Lalitha Pidaparthi Anitha Kotha Venkat Reddy Aleti Abhijeet Kumar Kohat Mridula R Kandadai Suryaprabha Turaga Jabeen A Shaik Suvarna Alladi Meena A Kanikannan Borgohain Rupam Subhash Kaul Source Type: research

Fifty years of stroke researches in India
Tapas Kumar Banerjee, Shyamal Kumar DasAnnals of Indian Academy of Neurology 2016 19(1):1-8Currently, the stroke incidence in India is much higher than Western industrialized countries. Large vessel intracranial atherosclerosis is the commonest cause of ischemic stroke in India. The common risk factors, that is, hypertension, diabetes, smoking, and dyslipidemia are quite prevalent and inadequately controlled; mainly because of poor public awareness and inadequate infrastructure. Only a small number of ischemic stroke cases are able to have the benefit of thrombolytic therapy. Benefits from stem cell therapy in established ...
Source: Annals of Indian Academy of Neurology - February 2, 2016 Category: Neurology Authors: Tapas Kumar BanerjeeShyamal Kumar Das Source Type: research

Crohns disease with central nervous system vasculitis causing subarachnoid hemorrhage due to aneurysm and cerebral ischemic stroke
We report a 39-year-old male who presented with headache, vomiting, and left-sided weakness in the known case of CD. Cross-sectional imaging (computed tomography and magnetic resonance imaging,) showed right gangliocapsular acute infarct with supraclinoid cistern subarachnoid hemorrhage (SAH). Cerebral digital substraction angiography (DSA) showed dilatation and narrowing of right distal internal carotid artery (ICA). Left ICA was chronically occluded. His inflammatory markers were significantly raised. Imaging features are suggestive of cerebral vasculitis. Arterial and venous infarcts due to thrombosis are known in CD. O...
Source: Annals of Indian Academy of Neurology - November 5, 2014 Category: Neurology Authors: Shaileshkumar S GargePooja D VyasPranav D ModiSharad Ghatge Source Type: research

Susceptibility weighted magnetic resonance imaging of brain: A multifaceted powerful sequence that adds to understanding of acute stroke
Conclusions: SWI has been previously shown to be sensitive in detecting hemorrhage; however is not routinely used in stroke evaluation. Our study shows that SWI, by virtue of identifying unsuspected hemorrhage, central occluded vessel, and venous congestion is additive in value to the routine MR exam and should be part of a routine MR brain in patients suspected of having an acute infarct.
Source: Annals of Indian Academy of Neurology - March 12, 2014 Category: Neurology Authors: Deepti NaikSanjaya ViswamitraAshok A KumarMG Srinath Source Type: research

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