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Association between thrombus composition and stroke etiology in the MR CLEAN Registry biobank
ConclusionThrombus composition is significantly associated with stroke etiology, with an increase in RBC and a decrease in F/P raising the odds for a non-cardioembolic cause. No difference between composition of cardioembolic thrombi and of undetermined origin was seen. This emphasizes the need for more extensive monitoring for arrhythmias and/or extended cardiac analysis in case of an undetermined origin.
Source: Neuroradiology - April 15, 2023 Category: Radiology Source Type: research

High-resolution MR vessel wall imaging in determining the stroke aetiology and risk stratification in isolated middle cerebral artery disease
ConclusionHigh-resolution MRVWI can help in identifying the aetiology of stroke. The HRVWI characteristics in ICAD can help in risk stratification.
Source: Neuroradiology - February 3, 2022 Category: Radiology Source Type: research

Observer variability of absolute and relative thrombus density measurements in patients with acute ischemic stroke
Conclusion Absolute thrombus density measurement has superior interobserver agreement compared to relative density measurement. Interobserver variation is smaller when multiple ROIs are used. Trained non-expert observers can accurately and reproducibly assess absolute thrombus densities using three ROIs.
Source: Neuroradiology - October 22, 2015 Category: Radiology Source Type: research

An old thrombus may potentially identify patients at higher risk of poor outcome in anterior circulation stroke undergoing thrombectomy
ConclusionThe presence of old thrombi, particularly those with focal hemosiderin, may aid in identifying patients with acute ischemic anterior circulation stroke who are at a higher risk of poor clinical outcome at 3-month follow-up.
Source: Neuroradiology - October 21, 2022 Category: Radiology Source Type: research

A back and forth manual aspiration technique using a SOFIA Plus catheter for acute ischemic stroke: technical note
ConclusionThis modified technique with back and forth movements of the SOFIA Plus catheter over the thrombus during aspiration may facilitate thrombectomy in AIS. However, further studies in larger groups are necessary to elucidate its efficacy and to compare with current techniques.
Source: Neuroradiology - November 13, 2018 Category: Radiology Source Type: research

Association of thrombus density and endovascular treatment outcomes in patients with acute ischemic stroke due to M1 occlusions
ConclusionIn patients with M1 occlusions, thrombus density was not clearly associated with procedural and clinical outcomes after EVT.
Source: Neuroradiology - May 16, 2022 Category: Radiology Source Type: research

A nomogram for predicting thrombus composition in stroke patients with large vessel occlusion: combination of thrombus density and perviousness with clinical features
ConclusionThis study has developed and internally validated an easy-to-use nomogram which can help predict clot composition and optimize therapeutic strategies for thrombectomy.
Source: Neuroradiology - September 6, 2022 Category: Radiology Source Type: research

Transcriptomic analysis of the harvested endothelial cells in a swine model of mechanical thrombectomy
ConclusionECs harvested during MT can be cultured and analyzed using single-cell transcriptomic techniques. This analysis can be implemented in clinical practice to study the EC gene expression of comorbidities, such as hypertension, diabetes mellitus, and metabolic syndrome, in patients suffering from acute ischemic stroke.
Source: Neuroradiology - May 14, 2018 Category: Radiology Source Type: research

Endovascular treatment in patients with middle cerebral artery occlusion of different aetiologies
ConclusionsPatients with acute MCA M1 occlusion stroke due to different pathogeneses had comparable successful recanalization rates and functional independence at 90  days. The optimal management for MCAO patients with different aetiologies requires further research.
Source: Neuroradiology - November 5, 2022 Category: Radiology Source Type: research

Distance to thrombus on MR angiography predicts outcome of middle cerebral artery occlusion treated with IV thrombolysis
Conclusions DT on CE-MRA is reliably measurable, correlates inversely with FLAIR-vascular hyperintensities, and predicts outcome in patients with acute MCA occlusion treated with IVT.
Source: Neuroradiology - July 11, 2015 Category: Radiology Source Type: research

Protected stent retriever thrombectomy prevents iatrogenic emboli in new vascular territories
Conclusion Our study demonstrates two things: First, SWI seems to be more sensitive to detect emboli than DWI and DSA and, second, proximal or distal protected stent retriever thrombectomy seems to prevent iatrogenic embolization into new vascular territories during retraction of the thrombus, but not downstream during mobilization of the thrombus. Both techniques should be investigated and refined further.
Source: Neuroradiology - August 29, 2015 Category: Radiology Source Type: research

Endovascular aspiration of a symptomatic free-floating common carotid artery thrombus
AbstractFree-floating thrombi of the common carotid artery (CCA) are a very rare cause of ischemic stroke. To date, only a few reports have been described in the academic literature. Revascularization is indicated due to the risk of thromboembolic disease and hemodynamic-related stroke syndromes. Medical treatment typically includes anticoagulation and, in some circumstances, open surgical thrombectomy is an additional option. Although rarely described in the literature, endovascular thrombectomy is a viable treatment alternative in these patients.
Source: Neuroradiology - August 14, 2018 Category: Radiology Source Type: research

Stent-thrombus interaction and the influence of aspiration on mechanical thrombectomy: evaluation of different stent retrievers in a circulation model
Conclusion Distal aspiration with intermediate catheters increases the efficacy of mechanical thrombectomy with stent retrievers significantly. In contrary to earlier suggestions, the interaction between the thrombus and the stent retriever is only superficial, rather than an integration of the thrombus into the retriever. No significant differences between the proven devices could be shown in our model.
Source: Neuroradiology - April 24, 2015 Category: Radiology Source Type: research

Added value of multiphase CTA imaging for thrombus perviousness assessment
ConclusionAssociation between TAI with functional outcome was optimal on arterial-phase CTA such that dynamic CTA imaging has no additional benefits in current thrombus perviousness assessment, thereby suggesting that the delay of contrast arrival at the clot is a key variable for patient functional outcome.
Source: Neuroradiology - September 30, 2017 Category: Radiology Source Type: research

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