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Stroke in sickle cell anaemia is more than stenosis and thrombosis: the role of anaemia and hyperemia in ischaemia
Source: British Journal of Haematology - November 10, 2016 Category: Hematology Authors: Michael M. Dowling, Fenella J. Kirkham Tags: Editorial Comment Source Type: research

Pregnancy loss and risk of ischaemic stroke and myocardial infarction
We investigated whether pregnancy loss increases the risk of arterial thrombosis in young women. Women (age 18–50 years) with ischaemic stroke (IS) or myocardial infarction (MI) and at least one pregnancy were compared for pregnancy loss in a control group. Odds ratios (OR) with 95% confidence intervals (CI), adjusted for matching variables, cardiovascular risk factors, cardiovascular family history and the presence of antiphospholipid antibodies, were calculated for the number of pregnancy losses as well as the type of unsuccessful pregnancy (early miscarriage, late miscarriage and stillbirth). 165 IS cases, 218 MI cas...
Source: British Journal of Haematology - April 6, 2016 Category: Hematology Authors: Alberto Maino, Bob Siegerink, Ale Algra, Ida Martinelli, Flora Peyvandi, Frits R. Rosendaal Tags: Research Paper Source Type: research

FXIIa inhibitor rHA‐Infestin‐4: Safe thromboprotection in experimental venous, arterial and foreign surface‐induced thrombosis
This study aimed to further assess the antithrombotic efficacy of the activated factor XII (FXIIa) inhibitor, rHA‐Infestin‐4, in several thrombosis models. In mice, rHA‐Infestin‐4 decreased occlusion rates in the mechanically‐induced arterial (Folt's) and the FeCl3‐induced venous thrombosis model. rHA‐Infestin‐4 also protected from FeCl3‐induced arterial thrombosis and from stasis‐prompted venous thrombosis in rabbits. Furthermore, rHA‐Infestin‐4 prevented occlusion in the arterio‐venous shunt model in mice and rabbits where thrombosis was induced via a foreign surface. In contrast to heparin, the...
Source: British Journal of Haematology - March 26, 2016 Category: Hematology Authors: Frauke May, Jennifer Krupka, Marion Fries, Ina Thielmann, Ingo Pragst, Thomas Weimer, Con Panousis, Bernhard Nieswandt, Guido Stoll, Gerhard Dickneite, Stefan Schulte, Marc W. Nolte Tags: Research Paper Source Type: research

Clinical and laboratory characteristics of children with venous thromboembolism and protein C‐deficiency: an observational Israeli‐German cohort study
Summary Venous thromboembolism [TE] is a multifactorial disease and protein C deficiency [PCD] constitutes a major risk factor. In the present study the prevalence of PCD and the clinical presentation at TE onset, including neonatal purpura fulminans, in a cohort of children are reported. In 367 unselected children (0·1–19 years) recruited between July 1996 and December 2013, a comprehensive thrombophilia screening was performed along with recording of anamnestic data. Twenty‐five of 338 children (7·4%) had PCD. Mean age at first TE onset was 10 years (range 0·1–18). Leading thromboembolic manifestations were ne...
Source: British Journal of Haematology - July 18, 2014 Category: Hematology Authors: Verena Limperger, Ulrich C. Klostermeier, Gili Kenet, Susanne Holzhauer, Martine Alhenc Gelas, Ulrich Finckh, Ralf Junker, Christine Heller, Barbara Zieger, Karin Kurnik, Ralf Knöfler, Rolf Mesters, Susan Halimeh, Ulrike Nowak‐Göttl Tags: Research Paper Source Type: research

Paradoxical protection from atherosclerosis and thrombosis in a mouse model of sickle cell disease
Summary Sickle cell disease (SCD) is associated with vascular complications including premature stroke. The role of atherothrombosis in these vascular complications is unclear. To determine the effect of SCD on atherosclerosis and thrombosis, mice with SCD along with controls were generated by transplantation of bone marrow from mice carrying the homozygous sickle cell mutation (Hbbhβs/hβs) or wild‐type mice (Hbb+/+) into C57BL6/J or apolipoprotein E deficient (Apoe−/−) recipient mice. At the time of sacrifice, 23–28 weeks following bone marrow transplantation, anaemia, reticulocytosis, and splenomegaly were pre...
Source: British Journal of Haematology - April 17, 2013 Category: Hematology Authors: Hui Wang, Wei Luo, Jintao Wang, Chiao Guo, Stephanie L. Wolffe, Julia Wang, Eddy B. Sun, Kori N. Bradley, Andrew D. Campbell, Daniel T. Eitzman Tags: Research Paper Source Type: research