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Reduction of glyoxalase 1 (GLO1) aggravates cerebrovascular remodeling via promoting the proliferation of basilar smooth muscle cells in hypertension.
Abstract Uncontrollable vascular smooth cell proliferation is responsible for vascular remodeling during hypertension development. Glyoxalase 1 (GLO1), the major enzyme detoxifying methylglyoxal, has a critical role in regulating proliferation of several cell types. However, little is known whether GLO1 is involved in cerebrovascular remodeling and basilar smooth muscle cell (BASMC) proliferation during hypertension. Here we explored the role of GLO1 in angiotensin II (Ang II)-induced cerebrovascular remodeling and proliferation of BASMCs and the underlying mechanisms. The protein expression of GLO1 in basilar art...
Source: Biochemical and Biophysical Research communications - August 12, 2019 Category: Biochemistry Authors: Gao M, Sun L, Liu YL, Xie JW, Qin L, Xue J, Wang YT, Guo KM, Ma MM, Li XY Tags: Biochem Biophys Res Commun Source Type: research