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Source: Frontiers in Immunology
Condition: Stroke

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Total 158 results found since Jan 2013.

Monoclonal antibodies neutralizing alpha-hemolysin, bicomponent leukocidins, and clumping factor A protected against Staphylococcus aureus-induced acute circulatory failure in a mechanically ventilated rabbit model of hyperdynamic septic shock
ConclusionThese results demonstrate the potential utility of a mechanically ventilated rabbit model that reproduced hallmark clinical features of hyperdynamic septic shock and the translational potential of immunotherapy targeting S. aureus virulence factors for the prevention of staphylococcal septic shock.
Source: Frontiers in Immunology - September 15, 2023 Category: Allergy & Immunology Source Type: research

The impact of EMA recommendations on the real-life use of Janus kinases inhibitors for rheumatoid arthritis: the Expanded Risk Score in RA as a tool to quantify the risk of cardiovascular events
ConclusionsRigorous application of EMA indications in clinical practice could result in the exclusion of a large proportion of RA patients from treatment with JAKis. A proper quantification of the risk for MACE by dedicated tools as ERS-RA is advocated to better tailor the management of RA.
Source: Frontiers in Immunology - August 31, 2023 Category: Allergy & Immunology Source Type: research

Role and regulatory mechanism of microRNA mediated neuroinflammation in neuronal system diseases
MicroRNAs (miRNAs) are small non-coding RNAs with the unique ability to degrade or block specific RNAs and regulate many cellular processes. Neuroinflammation plays the pivotal role in the occurrence and development of multiple central nervous system (CNS) diseases. The ability of miRNAs to enhance or restrict neuroinflammatory signaling pathways in CNS diseases is an emerging and important research area, including neurodegenerative diseases, stroke, and traumatic brain injury (TBI). In this review, we summarize the roles and regulatory mechanisms of recently identified miRNAs involved in neuroinflammation-mediated CNS dis...
Source: Frontiers in Immunology - August 11, 2023 Category: Allergy & Immunology Source Type: research

Tregs depletion aggravates activation of astrocytes by modulating IL-10/GXP4 following cerebral infarction
ConclusionTregs depletion attenuates renal fibrosis by modulating IL-10/GPX4 following cerebral infarction.
Source: Frontiers in Immunology - August 9, 2023 Category: Allergy & Immunology Source Type: research

Higher systemic immune-inflammation index and systemic inflammation response index levels are associated with stroke prevalence in the asthmatic population: a cross-sectional analysis of the NHANES 1999-2018
ConclusionIn asthmatics, higher levels of SII and SIRI significantly increased the prevalence of stroke, with its association being more pronounced in individuals with coexisting obesity and hyperlipidaemia. SII and SIRI are relatively stable novel inflammatory markers in the asthmatic population, with SIRI having a better predictive value for stroke prevalence than SII.
Source: Frontiers in Immunology - August 4, 2023 Category: Allergy & Immunology Source Type: research

The role of macrophage ion channels in the progression of atherosclerosis
Atherosclerosis is a complex inflammatory disease that affects the arteries and can lead to severe complications such as heart attack and stroke. Macrophages, a type of immune cell, play a crucial role in atherosclerosis initiation and progression. Emerging studies revealed that ion channels regulate macrophage activation, polarization, phagocytosis, and cytokine secretion. Moreover, macrophage ion channel dysfunction is implicated in macrophage-derived foam cell formation and atherogenesis. In this context, exploring the regulatory role of ion channels in macrophage function and their impacts on the progression of atheros...
Source: Frontiers in Immunology - July 31, 2023 Category: Allergy & Immunology Source Type: research

COVID, complement, and the brain
The brains of COVID-19 patients are affected by the SARS-CoV-2 virus, and these effects may contribute to several COVID-19 sequelae, including cognitive dysfunction (termed “long COVID” by some researchers). Recent advances concerning the role of neuroinflammation and the consequences for brain function are reviewed in this manuscript. Studies have shown that respiratory SARS-CoV-2 infection in mice and humans is associated with selective microglial reactivity in the white matter, persistently impaired hippocampal neurogenesis, a decrease in the number of oligodendrocytes, and myelin loss. Brain MRI studies have reveal...
Source: Frontiers in Immunology - July 18, 2023 Category: Allergy & Immunology Source Type: research

Kidney function and cardiovascular diseases: a large-scale observational and Mendelian randomization study
ConclusionOur study provides evidence for causal effects of CVDs on kidney function. However, the evidence to support the causal effects of kidney function on CVDs is currently insufficient. Further mechanistic studies are required to determine the causality.
Source: Frontiers in Immunology - July 17, 2023 Category: Allergy & Immunology Source Type: research

Identification of cell death-related biomarkers and immune infiltration in ischemic stroke between male and female patients
ConclusionThese findings contribute to a better knowledge of immune cell infiltration and their corresponding molecular mechanisms of cell death and offer distinct clinically relevant biological targets for IS patients of different genders.
Source: Frontiers in Immunology - June 26, 2023 Category: Allergy & Immunology Source Type: research

The intestinal γδ T cells: functions in the gut and in the distant organs
Located in the frontline against the largest population of microbiota, the intestinal mucosa of mammals has evolved to become an effective immune system. γδ T cells, a unique T cell subpopulation, are rare in circulation blood and lymphoid tissues, but rich in the intestinal mucosa, particularly in the epithelium. Via rapid production of cytokines and growth factors, intestinal γδ T cells are key contributors to epithelial homeostasis and immune surveillance of infection. Intriguingly, recent studies have revealed that the intestinal γδ T cells may play novel exciting functions ranging from epithelial plasticity and ...
Source: Frontiers in Immunology - June 16, 2023 Category: Allergy & Immunology Source Type: research

Neutrophil percentage to albumin ratio is associated with stroke-associated pneumonia and poor outcome in patients with spontaneous intracerebral hemorrhage
ConclusionHigher NPAR is independently associated with SAP and poor functional outcome in patients with ICH. Our findings suggest that early prediction of SAP is feasible by using a simple biomarker NPAR.
Source: Frontiers in Immunology - June 14, 2023 Category: Allergy & Immunology Source Type: research

Netrin-1 controls inflammation in response to ischemic stroke through altering microglia phenotype
ConclusionOur study highlights the potential of targeting Netrin-1 and its receptors as a promising therapeutic strategy for promoting post-ischemic survival and functional recovery.
Source: Frontiers in Immunology - June 14, 2023 Category: Allergy & Immunology Source Type: research

Endothelial glycocalyx injury is involved in heatstroke-associated coagulopathy and protected by N-acetylcysteine
DiscussionOur results indicate that the poor prognosis of HS patients correlates with severe coagulation disorders, coagulation abnormalities in HS rats are associated with the damage of EGCX, and NAC improves HS-induced coagulopathy, probably through its protection against EGCX injury by preventing ROS generation.
Source: Frontiers in Immunology - June 6, 2023 Category: Allergy & Immunology Source Type: research

Blocking autofluorescence in brain tissues affected by ischemic stroke, hemorrhagic stroke, or traumatic brain injury
In conclusion, the optimized SBB pretreatment protocol blocks brain section autofluorescence of the three acute brain injury models.
Source: Frontiers in Immunology - May 29, 2023 Category: Allergy & Immunology Source Type: research

Circulating levels of cytokines and risk of cardiovascular disease: a Mendelian randomization study
ConclusionThe present study provides supportive evidence that genetic predisposition to levels of certain cytokines causally affects the development of specific type of CVD. These findings have important implications for the creation of novel therapeutic strategies targeting these cytokines as a means of preventing and treating CVD.
Source: Frontiers in Immunology - May 25, 2023 Category: Allergy & Immunology Source Type: research