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Source: Journal of Stroke and Cerebrovascular Diseases
Condition: Stroke

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Total 6741 results found since Jan 2013.

A Blood-based Biomarker Panel to Detect Acute Stroke
Background: The aim of this study was to develop an adjunctive, peripheral biomarker test to differentiate ischemic strokes, intracranial hemorrhages (ICHs), and stroke mimics in the acute setting.Methods: Serum samples were collected from 167 patients who presented with an acute neurologic deficit within 24 hours of symptom onset. Patients were adjudicated to ischemic stroke, ICH, and mimic pathology groups based on clinical and radiographic findings. Samples were tested for levels of 262 potential markers. A multivariate Cox proportional hazards regression model of 5 biomarkers was built by stepwise selection and valida...
Source: Journal of Stroke and Cerebrovascular Diseases - October 10, 2013 Category: Neurology Authors: Richa Sharma, Stephanie Macy, Kara Richardson, Yuliya Lokhnygina, Daniel T. Laskowitz Tags: Original Articles Source Type: research

Brain Natriuretic Peptide in Acute Ischemic Stroke
Elevated serum brain natriuretic peptide (BNP) levels are associated with cardioembolic stroke mainly because of atrial fibrillation (AF). However, the mechanisms of increased serum BNP levels are hitherto unclear. We aimed to identify the factors associated with increased BNP levels in patients with acute ischemic stroke. We measured serum BNP levels in consecutive patients aged 18 years or older. Stroke subtypes were classified using the Trial of ORG 10172 in Acute Stroke Treatment criteria. Categorical variables included age, sex, smoking status, alcohol consumption status, hypertension, diabetes mellitus, dyslipidemia...
Source: Journal of Stroke and Cerebrovascular Diseases - October 10, 2013 Category: Neurology Authors: Kenji Maruyama, Tsuyoshi Shiga, Mutsumi Iijima, Saori Moriya, Satoko Mizuno, Sono Toi, Kotaro Arai, Kyomi Ashihara, Kayoko Abe, Shinichiro Uchiyama Tags: Original Articles Source Type: research

Does Symptom Onset to Primary Stroke Center Time Goals Affect Stroke Outcome?
Background: Treating acute ischemic stroke (AIS) within 4.5 hours and door-to-needle time of less than 60 minutes may optimize recovery. It is unknown if onset to Primary Stroke Center (PSC) time goals affect outcome. The purpose of this study was to examine effects of symptom onset to PSC time goals on outcome.Methods: Analysis included prospectively collected data from the University of California San Diego Specialized Program of Treatment Research in Acute Stroke. All AIS patients treated with intravenous recombinant tissue plasminogen activator were included if treated within 270 minutes, and 90-day modified Rankin ...
Source: Journal of Stroke and Cerebrovascular Diseases - October 7, 2013 Category: Neurology Authors: Bryant Chee, Rema Raman, Karin Ernstrom, Amy K. Guzik, Thomas M. Hemmen, Karen S. Rapp, Brett C. Meyer, Dawn M. Meyer Tags: Original Articles Source Type: research

The Impact of Comprehensive Stroke Care Capacity on the Hospital Volume of Stroke Interventions: A Nationwide Study in Japan: J-ASPECT Study
We examined the effect of hospital characteristics, having a t-PA protocol, and the number of fulfilled CSC items (total CSC score) on the hospital volume of t-PA infusion, removal of intracerebral hemorrhage, and coiling and clipping of intracranial aneurysms performed in 2009.Results: Approximately 55% of hospitals responded to the survey. Facilities with t-PA protocols (85%) had a significantly higher likelihood of having 23 CSC items, for example, personnel (eg, neurosurgeons: 97.3% versus 66.1% and neurologists: 51.3% versus 27.7%), diagnostic (eg, digital cerebral angiography: 87.4% versus 43.2%), specific expertise...
Source: Journal of Stroke and Cerebrovascular Diseases - October 7, 2013 Category: Neurology Authors: Koji Iihara, Kunihiro Nishimura, Akiko Kada, Jyoji Nakagawara, Kazunori Toyoda, Kuniaki Ogasawara, Junichi Ono, Yoshiaki Shiokawa, Toru Aruga, Shigeru Miyachi, Izumi Nagata, Shinya Matsuda, Koichi B. Ishikawa, Akifumi Suzuki, Hisae Mori, Fumiaki Nakamura, Tags: Original Articles Source Type: research

Quality of Life after Lacunar Stroke: The Secondary Prevention of Small Subcortical Strokes Study
Background: We sought to describe the course and predictors of quality of life (QOL) after lacunar stroke. We hypothesized that there is a decline in QOL after recovery from lacunar stroke.Methods: The Secondary Prevention of Small Subcortical Strokes is a clinical trial in lacunar stroke patients with annual assessments of QOL with the stroke-specific QOL score. The overall score was used and analyzed as a continuous variable (range 0-5). We fit linear mixed models to assess the trend in QOL over time, assuming linearity of time, and adjusted for demographics, medical risk factors, cognitive factors, and functional status...
Source: Journal of Stroke and Cerebrovascular Diseases - October 30, 2013 Category: Neurology Authors: Mandip S. Dhamoon, Leslie A. McClure, Carole L. White, Helena Lau, Oscar Benavente, Mitchell S.V. Elkind Tags: Original Articles Source Type: research

Synthetic Cannabis and Acute Ischemic Stroke
We describe 2 cases that introduce a previously unreported association between synthetic cannabis use and ischemic stroke in young adults. A 22-year-old woman presented with dysarthria, left hemiplegia, and left hemianesthesia within hours of first use of synthetic cannabis. She was healthy and without identified stroke risk factors other than oral contraceptive use and a patent foramen ovale without venous thromboses. A 26-year-old woman presented with nonfluent aphasia, left facial droop, and left hemianesthesia approximately 12 hours after first use of synthetic cannabis. Her other stroke risk factors included migraine ...
Source: Journal of Stroke and Cerebrovascular Diseases - October 10, 2013 Category: Neurology Authors: Miya E. Bernson-Leung, Lester Y. Leung, Sandeep Kumar Tags: Case Reports Source Type: research

Nontraumatic Convexal Subarachnoid Hemorrhage Concomitant with Acute Ischemic Stroke
Conclusions: In this retrospective review of cases with ischemic stroke and cSAH, over half of patients had occlusion of major arteries. Cerebral amyloid angiopathy was suggested by magnetic resonance imaging findings and subsequent events in 3 patients. The overall outcome was unfavorable although the causal relationship with cSAH was unclear.
Source: Journal of Stroke and Cerebrovascular Diseases - March 17, 2014 Category: Neurology Authors: Makoto Nakajima, Yuichiro Inatomi, Toshiro Yonehara, Teruyuki Hirano, Yukio Ando Tags: Original Articles Source Type: research

Outcomes in People after Stroke Attending an Adapted Cardiac Rehabilitation Exercise Program: Does Time from Stroke Make a Difference?
The objectives of the present study are (1) to evaluate the effects of a CRP in participants with motor impairment after stroke and (2) to explore the effects of elapsed time from stroke on physiological/quality-of-life outcomes.Methods: The CRP included 24 weeks of resistance and aerobic training. Primary outcomes in 120 participants, 25.4 ± 42.3 (mean ± standard deviation) months after stroke, included 6-minute walk distance (6MWD), VO2peak, timed repeated sit-to-stand performance, and affected-side isometric knee extensor strength (IKES). Secondary measures included gait characteristics (cadence, step lengths, an...
Source: Journal of Stroke and Cerebrovascular Diseases - April 7, 2014 Category: Neurology Authors: Susan Marzolini, Ada Tang, William McIlroy, Paul I. Oh, Dina Brooks Tags: Original Articles Source Type: research

Occurrence and Predictors of Persistent Impaired Glucose Tolerance After Acute Ischemic Stroke or Transient Ischemic Attack
Conclusions: Half of the patients with impaired glucose tolerance after a TIA or ischemic stroke have persistent impaired glucose tolerance. We provide a prediction model to identify patients at risk of persistent impaired glucose tolerance, with statin use, triglyceride, and fasting plasma glucose as the most important predictors, which after external validation might be used to optimize secondary prevention.
Source: Journal of Stroke and Cerebrovascular Diseases - April 10, 2014 Category: Neurology Authors: Susanne Fonville, Heleen M. den Hertog, Adrienne A.M. Zandbergen, Peter J. Koudstaal, Hester F. Lingsma Tags: Original Articles Source Type: research

Spontaneous Swallow Frequency Compared with Clinical Screening in the Identification of Dysphagia in Acute Stroke
Conclusions: Spontaneous SFA has high potential to identify dysphagia in acute stroke with psychometric properties equal or superior to clinical screening protocols.
Source: Journal of Stroke and Cerebrovascular Diseases - August 4, 2014 Category: Neurology Authors: Michael A. Crary, Giselle D. Carnaby, Isaac Sia Tags: Original Articles Source Type: research

Effect of Intravenous Thrombolysis on Stroke Associated with Atrial Fibrillation
Conclusions: These results should encourage the use of IVT in AF-associated strokes.
Source: Journal of Stroke and Cerebrovascular Diseases - July 14, 2014 Category: Neurology Authors: Visnja Padjen, Dejana Jovanovic, Ivana Berisavac, Marko Ercegovac, Maja Stefanovic Budimkic, Predrag Stanarcevic, Ljiljana Beslac Bumbasirevic Tags: Original Articles Source Type: research

Association between Helicobacter pylori Infection and Stroke: A Meta-analysis of Prospective Observational Studies
Conclusions: In conclusion, our formal meta-analysis indicated no strong association between H. pylori infection and stroke, neither in those with cytotoxin-associated gene-A–positive infection. We believe that future epidemiologic studies of H. pylori and stroke are unlikely to be fruitful.
Source: Journal of Stroke and Cerebrovascular Diseases - September 29, 2014 Category: Neurology Authors: Min Yu, Yangbo Zhang, Zhen Yang, Jiangwu Ding, Chuan Xie, Nonghua Lu Tags: Original Articles Source Type: research

A Prescription at Discharge Improves Long-term Adherence for Secondary Stroke Prevention
Conclusions: Provision of a prescription strengthens adherence at 1 week from discharge for both prior and new users of antihypertensive and lipid-lowering drugs. Medication adherence at 1 week after discharge for acute ischemic stroke predicts adherence for secondary preventive therapies at 1 and 2 years.
Source: Journal of Stroke and Cerebrovascular Diseases - August 22, 2014 Category: Neurology Authors: Jenny P. Tsai, Paula A. Rochon, Stavroula Raptis, Susan E. Bronskill, Chaim M. Bell, Gustavo Saposnik Tags: Original Articles Source Type: research

Association of Variants in KCNK17 Gene with Ischemic Stroke and Cerebral Hemorrhage in a Chinese Population
Conclusions: The T carrier of an SNP (rs12214600) is associated with reduced risk of cerebral hemorrhage in the Chinese population, together with previous findings that SNPs rs10947803 and rs12214600 in the KCNK17 gene are associated with hemorrhagic stroke, but none of the SNPs tested had an association with ischemic stroke. KCNK17 may be important in the pathogenesis of cerebral hemorrhage.
Source: Journal of Stroke and Cerebrovascular Diseases - September 1, 2014 Category: Neurology Authors: Lingbin He, Qingfeng Ma, Yongqin Wang, Xin Liu, Yuan Yuan, Yongzhi Zhang, Wenjing Ou, Lisheng Liu, Xuerui Tan, Xingyu Wang Tags: Original Articles Source Type: research

Patient Awareness and Perception of Stroke Symptoms and the Use of 911
Conclusions: African–Americans used 911 at a significantly higher rate. Use of 911 may be related to access to transportation, lack of insurance, or proximity to the hospital although this information was not available. Interventions are needed to improve patient arrival times to telemedicine equipped emergency departments after stroke.
Source: Journal of Stroke and Cerebrovascular Diseases - September 10, 2014 Category: Neurology Authors: Angela M. Malek, Robert J. Adams, Ellen Debenham, Andrea D. Boan, Abby S. Kazley, Hyacinth I. Hyacinth, Jenifer H. Voeks, Daniel T. Lackland Tags: Original Articles Source Type: research