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Source: Brain Research
Condition: Stroke
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Total 498 results found since Jan 2013.
Antioxidant and Anti-apoptotic Effects of Cannabidiol in Model of Ischemic Stroke in Rats
Brain Res Bull. 2022 Jan 11:S0361-9230(22)00004-1. doi: 10.1016/j.brainresbull.2022.01.001. Online ahead of print.ABSTRACTOne of the main non-psychoactive phytocannabinoids of cannabis is cannabidiol (CBD), which has attracted much attention for its neuroprotective roles. The present study was designed to assess whether pretreatment of CBD can attenuate two of the destructive processes of cerebral ischemia, including oxidative stress and cell death. The male rats were randomly divided into 6 main groups (control, MCAO, vehicle, and CBD-treated groups). Using stereotaxic surgery, a cannula was inserted into the right latera...
Source: Brain Research - January 15, 2022 Category: Neurology Authors: Sepideh Khaksar Mohammadreza Bigdeli Arash Samiee Zahra Shirazi-Zand Source Type: research
Tat-SynGAP improves angiogenesis and post-stroke recovery by inhibiting MST1/JNK signaling
In conclusion, Tat-SynGAP (670-685aa) reduces neuronal apoptosis and cerebral infarction volume and maintains vascular stability and blood-brain barrier integrity by inhibiting MST1/JNK signaling pathway.PMID:34990733 | DOI:10.1016/j.brainresbull.2021.12.013
Source: Brain Research - January 6, 2022 Category: Neurology Authors: Hui Yang Zhenqian Liu Xiaomei Liu Xiaowei Cao Mo Chen Shiying Lou Liangqun Rong Yun Xu Qingxiu Zhang Source Type: research
Risk of ischemic stroke in patients with COVID-19 infection: A systematic review and meta-analysis
This study systematically reviewed published studies and conducted meta-analysis to evaluate the association between the risk of ischemic stroke and COVID-19. This study was conducted according to guidelines from the Preferred Reporting Items for Systematic Reviews and Meta-Analyses. The protocol used in this study had been registered in the International Prospective Register of Systematic Reviews. EMBASE, PubMed, Cochrane Library and Web of Science were searched from 1st December 2019-19th February 2021. This systematic review and meta-analysis analysed the combined effect estimations based on odds ratios (OR) with the ra...
Source: Brain Research - January 3, 2022 Category: Neurology Authors: Yanhua Cui Bing Zhao Tianbai Li Zhaofei Yang Song Li Weidong Le Source Type: research
Impact of MRI on decision-making in ICU patients with disorders of consciousness
CONCLUSION: MRI results changed decision-making in 3 of 4 ICU patients, but radiological findings were not predictive of clinical decision-making. This highlights the need to better understand the effects of neuroimaging on management decisions. How MRI influences decision-making in the ICU is an important avenue for research to improve acute DoC management.PMID:34973968 | DOI:10.1016/j.bbr.2021.113729
Source: Brain Research - January 2, 2022 Category: Neurology Authors: Simon S Albrechtsen Robert G C Riis Moshgan Amiri Gry Tanum Ove Bergdal Morten Blaabjerg Claus Z Simonsen Daniel Kondziella Source Type: research
Different training patterns at recovery stage improve cognitive function in ischemic stroke rats through regulation of the axonal growth inhibitor pathway
This study investigated the effects of SRT and RWE, at the recovery stage, on the cognitive function of transient middle cerebral artery occlusion (tMCAO) rats and explored their association with NgR1/Rho-A/ROCK/LOTUS/LGI1 signaling. Adult Sprague-Dawley rats (n = 55) were divided into four groups after pretraining: SRT, RWE, tMCAO, and Sham. Rats were subjected to modified neurological severity score (mNSS) measurements and forelimb grip strength and the Morris water maze tests. Using immunofluorescence and western blotting, we evaluated axonal growth inhibitor expression in the peri-infarct cortex on days 28 and 56 after...
Source: Brain Research - December 31, 2021 Category: Neurology Authors: Chao Li Ruifang Sun Jiemei Chen Jiena Hong Ju Sun Yan Zeng Xue Zhang Zulin Dou Hongmei Wen Source Type: research
GSK-3 β inhibition elicits a neuroprotection by restoring lysosomal dysfunction in neurons via facilitation of TFEB nuclear translocation after ischemic stroke
Brain Res. 2021 Dec 27:147768. doi: 10.1016/j.brainres.2021.147768. Online ahead of print.ABSTRACTLysosomal dysfunction is an essential pathogenesis of autophagic neuronal injury after ischemic stroke. As a result of cerebral ischemia, transcription factor EB (TFEB) is greatly phosphorylated by prominently activated glycogen synthase kinase-3β (GSK-3β). This increased TFEB phosphorylation decreases its nuclear translocation and subsequently leads to reduced lysosomal biosynthesis, which ultimately results in lysosomal dysfunction. The present study is to investigate whether the lysosomal dysfunction in neurons can be res...
Source: Brain Research - December 30, 2021 Category: Neurology Authors: Zhang Yongjie Wu Zhiyuan Huang Zhiwen Liu Yuyuan Chen Xuemei Zhao Xiaoming He Hongyun Deng Yihao Source Type: research
4R-cembranoid protects neuronal cells from oxygen-glucose deprivation by modulating microglial cell activation
In conclusion, our study demonstrated that the neuroprotective effects of 4R were through the regulation of microglial activation by promoting the protective M2 activation and inhibiting the damaging M1 activation. Therefore, the findings of this study suggest that 4R could be a promising lead structure for the development of drugs for the treatment of ischemic stroke and other neurodegenerative diseases with an inflammatory component involved.PMID:34942325 | DOI:10.1016/j.brainresbull.2021.12.007
Source: Brain Research - December 23, 2021 Category: Neurology Authors: Hefei Fu Jiapeng Wang Jie Wang Langni Liu Jianxiong Jiang Jiukuan Hao Source Type: research
Task effects on functional connectivity measures after stroke
This study examined working memory, discrete pedaling, continuous pedaling and language tasks. Functional magnetic resonance imaging was used to examine regional and inter-regional brain network function in 14 stroke and 16 control participants. Independent component analysis was used to identify 149 regions of interest (ROI). Using the inter-regional connectivity measurements, the weighted sum was calculated across only regions associated with a given task. Both inter-regional connectivity and regional connectivity were greater during each of the tasks as compared to the resting state. The working memory and discrete peda...
Source: Brain Research - December 3, 2021 Category: Neurology Authors: Kaleb Vinehout Sheila Schindler-Ivens Jeffrey R Binder Brian D Schmit Source Type: research
Silent information regulator 1 ameliorates oxidative stress injury via PGC-1 α/PPARγ-Nrf2 pathway after ischemic stroke in rat
CONCLUSION: Overall, our data indicated that SIRT1 directly mediated the PGC-1α/PPARγ pathway in response to focal cerebral ischemia/reperfusion-induced neurological deficit, providing insights into the treatment of focal cerebral ischemia/reperfusion injury.PMID:34774993 | DOI:10.1016/j.brainresbull.2021.11.001
Source: Brain Research - November 14, 2021 Category: Neurology Authors: Yang Zhou Li Peng Yixin Li Yong Zhao Source Type: research
