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Source: Journal of Neurology, Neurosurgery and Psychiatry
Condition: Stroke

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Total 402 results found since Jan 2013.

Selecting stroke patients for thrombectomy: is CTA+ASPECTS enough?
Since 2014, a series of randomised controlled trails (RCTs) have demonstrated the benefit of endovascular thrombectomy (EVT) on functional outcome for the participants who had acute ischaemic stroke (AIS) with occlusion of a proximal intracranial artery in the anterior circulation. The characteristics of the people enrolled in these RCTs have been used to define recommended criteria to select patients for thrombectomy in clinical practice. The initial group of RCTs largely enrolled participants early after AIS (mostly under 6 hours) who had National Institutes of Health stroke scale scores ≥6 (range 0–42 with lowe...
Source: Journal of Neurology, Neurosurgery and Psychiatry - September 14, 2023 Category: Neurosurgery Authors: Powers, W. Tags: Editorial commentaries Source Type: research

Endovascular treatment for large-core ischaemic stroke: a meta-analysis of randomised controlled clinical trials
Conclusion EVT appears to be effective and safe and may be considered for the treatment of large-core AIS, as assessed by ASPECTS of 2–5 or volumetric methods. PROSPERO registration number CRD42022334417.
Source: Journal of Neurology, Neurosurgery and Psychiatry - September 14, 2023 Category: Neurosurgery Authors: Palaiodimou, L., Sarraj, A., Safouris, A., Magoufis, G., Lemmens, R., Sandset, E. C., Turc, G., Psychogios, M., Tsivgoulis, G. Tags: Editor's choice Cerebrovascular disease Source Type: research

Association of age with 1-year outcome in patients with acute ischaemic stroke treated with thrombectomy: real-world analysis in 18 506 patients
Conclusions In this large ‘real-world’ cohort, outcomes after mechanical thrombectomy were strongly associated with age. Of patients aged ≥80 years more than half were dead and less than one-fifth were functionally independent at 1 year. Certain comorbidities and ventilation >48 hours were associated with even worse outcomes.
Source: Journal of Neurology, Neurosurgery and Psychiatry - July 13, 2023 Category: Neurosurgery Authors: Beuker, C., Köppe, J., Feld, J., Meyer, C. L., Dröge, P., Ruhnke, T., Günster, C., Wiendl, H., Reinecke, H., Minnerup, J. Tags: Open access Cerebrovascular disease Source Type: research

Long-term outcomes of moyamoya disease versus atherosclerosis-associated moyamoya vasculopathy using high-resolution MR vessel wall imaging
Conclusions Patients with MMD had a higher risk of ischaemic stroke than those with AS-MMV, and patients with both MMD and AS-MMV could benefit from EDAS. Our findings suggest that HRMRI could be used to identify those who are at a higher risk of future cerebrovascular events.
Source: Journal of Neurology, Neurosurgery and Psychiatry - June 14, 2023 Category: Neurosurgery Authors: Lu, M., Zhang, H., Liu, S., Liu, D., Peng, P., Hao, F., Yuan, F., Liu, Y., Sheng, F., Zhang, L., Zhao, X., He, Y., Han, C., Cai, J. Tags: Editor's choice Cerebrovascular disease Source Type: research

Deep learning-based personalised outcome prediction after acute ischaemic stroke
Conclusions Deep learning models using clinical data and brain images could improve the prediction of MACEs and provide personalised outcome prediction for patients with AIS. Deep learning models will allow us to develop more accurate and tailored prognostic prediction systems that outperform traditional models.
Source: Journal of Neurology, Neurosurgery and Psychiatry - April 13, 2023 Category: Neurosurgery Authors: Kim, D.-Y., Choi, K.-H., Kim, J.-H., Hong, J., Choi, S.-M., Park, M.-S., Cho, K.-H. Tags: Cerebrovascular disease Source Type: research

The prospects for poststroke neural repair with vagal nerve stimulation
Vagal nerve stimulation is a new candidate for promoting neural repair after stroke but there is work to do Stroke is one of the major global healthcare problems with over 100 million stroke survivors worldwide.1 It is no longer simply a disease of the elderly, with 63% of the one-in-four adults who will go on to have a stroke being under the age of 70.1 Treatment to help recovery is often restricted to the first 6 months, despite stroke being a long-term condition from which recovery can be a lifelong process. There are three key areas where advances will have a major impact. First, accept that higher doses of motor, lang...
Source: Journal of Neurology, Neurosurgery and Psychiatry - March 14, 2023 Category: Neurosurgery Authors: Ward, N. Tags: Open access Editorial commentaries Source Type: research

Vagus nerve stimulation paired with rehabilitation for motor function, mental health and activities of daily living after stroke: a systematic review and meta-analysis
Conclusion The results suggest VNS+Rehab showed better motor function outcomes in patients after stroke, while no better than Rehab on mental health or ADL. Combinations of phase of stroke, specific parameters of VNS and VNS intervention frequency are key modulators of VNS effects. Trial registration number CRD42022310194
Source: Journal of Neurology, Neurosurgery and Psychiatry - March 14, 2023 Category: Neurosurgery Authors: Gao, Y., Zhu, Y., Lu, X., Wang, N., Zhu, S., Gong, J., Wang, T., Tang, S.-W. Tags: Cerebrovascular disease Source Type: research

Cerebroprotection in the endovascular era: an update
Despite advances in clinical diagnosis and increasing numbers of patients eligible for revascularisation, ischaemic stroke remains a significant public health concern accounting for 3.3 million deaths annually. In addition to recanalisation therapy, patient outcomes could be improved through cerebroprotection, but all translational attempts have remained unsuccessful. In this narrative review, we discuss potential reasons for those failures. We then outline the diverse, multicellular effects of ischaemic stroke and the complex temporal sequences of the pathophysiological cascade during and following ischaemia, reperfusion,...
Source: Journal of Neurology, Neurosurgery and Psychiatry - March 14, 2023 Category: Neurosurgery Authors: Schneider, A. M., Regenhardt, R. W., Dmytriw, A. A., Patel, A. B., Hirsch, J. A., Buchan, A. M. Tags: Editor's choice Cerebrovascular disease Source Type: research

Trends and inequities in the diagnosis and treatment of poststroke depression: a retrospective cohort study of privately insured patients in the USA, 2003-2020
Conclusions In this insured population, we identify potential inequities in clinical management of poststroke depression by gender, race/ethnicity and age that may reflect barriers other than access to healthcare.
Source: Journal of Neurology, Neurosurgery and Psychiatry - February 14, 2023 Category: Neurosurgery Authors: Elser, H., Caunca, M., Rehkopf, D. H., Andres, W., Gottesman, R. F., Kasner, S. E., Yaffe, K., Schneider, A. L. C. Tags: JNNP Patients' choice Cerebrovascular disease Source Type: research

Role of small acute hyperintense lesions in long-term progression of cerebral small vessel disease and clinical outcome: a 14-year follow-up study
Conclusion Presence of a DWI+lesion in patients with SVD is associated with greater radiological progression of SVD and cognitive decline compared with patients without DWI+lesions.
Source: Journal of Neurology, Neurosurgery and Psychiatry - January 11, 2023 Category: Neurosurgery Authors: Verburgt, E., Janssen, E., Jacob, M. A., Cai, M., ter Telgte, A., Wiegertjes, K., Kessels, R. P. C., Norris, D. G., Marques, J., Duering, M., Tuladhar, A. M., De Leeuw, F.-E. Tags: Cerebrovascular disease Source Type: research

Circadian rhythm of ischaemic core progression in human stroke
Discussion These results suggest that human infarct progression varies across the 24-hour cycle with potential implications for the design and interpretation of neuroprotection trials.
Source: Journal of Neurology, Neurosurgery and Psychiatry - December 14, 2022 Category: Neurosurgery Authors: Reidler, P., Brehm, A., Sporns, P. B., Burbano, V. G., Stueckelschweiger, L., Broocks, G., Liebig, T., Psychogios, M.-N., Ricke, J., Dimitriadis, K., Dichgans, M., Kunz, W. G., Tiedt, S. Tags: Editor's choice Cerebrovascular disease Source Type: research

14 Saving Adam from the apple: using transcranial magnetic stimulation as a transdiagnostically relevant tool to decrease cue-reactivity
Professor Hanlon’s scientific research has been to map neural circuit irregularities in substance dependent populations and then modulate these circuits using brain stimulation techniques or neurofeedback. She is leading NIH-funded research directed at longitudinal investigations of neural connectivity in cocaine & alcohol dependent individuals undergoing substance abuse treatment, & developing patient-tailored brain stimulation protocols which may either enhance cognitive control or attenuate craving in treatment seeking individuals. Her trainees & collaborators are pioneering non-invasive neuromodulator...
Source: Journal of Neurology, Neurosurgery and Psychiatry - November 14, 2022 Category: Neurosurgery Authors: Hanlon, C. A. Tags: Speakers Short Biographies and Abstracts Source Type: research

Risk of stroke in multiple sclerosis and neuromyelitis optic spectrum disorder: a Nationwide cohort study in South Korea
Conclusions The risk of stroke is increased in patients with MS and NMOSD and seemed comparable between the two conditions. This is the first study that estimates the risk of stroke in patients with MS and NMOSD within the same population.
Source: Journal of Neurology, Neurosurgery and Psychiatry - October 14, 2022 Category: Neurosurgery Authors: Cho, E. B., Yeo, Y., Jung, J. H., Jeong, S.-M., Han, K.-d., Shin, D. W., Min, J.-H. Tags: Multiple sclerosis Source Type: research

Global impact of the COVID-19 pandemic on subarachnoid haemorrhage hospitalisations, aneurysm treatment and in-hospital mortality: 1-year follow-up
Conclusion During the first year of the pandemic, there was a decrease in aSAH admissions volume, driven by a decrease in mild to moderate presentation of aSAH. There was an increase in the ruptured aneurysm coiling rate but neither change in the ruptured aneurysm clipping rate nor change in aSAH in-hospital mortality. Trial registration number NCT04934020.
Source: Journal of Neurology, Neurosurgery and Psychiatry - September 14, 2022 Category: Neurosurgery Authors: SVIN COVID-19 Global SAH Registry, Nguyen, Qureshi, Klein, Yamagami, Mikulik, Etminan, Abdalkader, Mansour, Czlonkowska, Lo, Sathya, Demeestere, Tsivgoulis, Sakai, Sedova, Kristoffersen, Mohammaden, Lereis, Scollo, Ma, Rahman, Bonnet, Cortier, Raedt, Lemm Tags: Editor's choice, COVID-19 Cerebrovascular disease Source Type: research

Consider alternative causes before allocating acute ischaemic stroke to COVID-19
We read with interest the excellent article by Dmytriw et al reported on a retrospective, multicenter cohort study of patients with COVID-19 with acute ischaemic stroke (AIS) admitted to stroke units in the USA and Canada between March and August 2020.1 The primary endpoint was a modified Rankin Scale (mRS) of 5–6 and the secondary endpoints were an mRS<3, ordinal RS, symptomatic intracerebral haemorrhage and complications during hospitalisation.1 It has been established that there may be an association between COVID-19-associated AIS and severe outcome or death, and that the neutrophil to lymphocyte ratio predict...
Source: Journal of Neurology, Neurosurgery and Psychiatry - September 14, 2022 Category: Neurosurgery Authors: Finsterer, J. Tags: COVID-19 PostScript Source Type: research