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Successful outcome after traumatic rupture and secondary thrombosis of the superior sagittal sinus
A 15-year-old adolescent was admitted to the emergency department after a car accident because of severe traumatic brain injury. Upon arrival, he was sedated and intubated because of a Glasgow Coma Scale score below 8. He had isocoria with reactive pupils. An occipital puncture wound (diameter 2 cm) was profusely bleeding. His blood pressure was 85/45 mm Hg. Laboratory values identified a haemoglobin level of 4.6 mmol/l. A CT scan of the brain demonstrated a comminuted-depressed fracture of the parietal bone in the midline with a rupture of the superior sagittal sinus (SSS) and secondary thrombosis (fig...
Source: Journal of Neurology, Neurosurgery and Psychiatry - September 2, 2013 Category: Neurosurgery Authors: Oudeman, E. A., De Witt Hamer, P. C. Tags: Coma and raised intracranial pressure, Neuroimaging, Neurological injury, Stroke, Trauma CNS / PNS, Hypertension, Radiology, Drugs: musculoskeletal and joint diseases, Radiology (diagnostics), Trauma, Injury Neurological pictures Source Type: research

Autoimmune gabab antibody encephalitis associated with non-malignant lung lesion
GABAb receptor autoimmune encephalitis is a potentially treatable disorder characterised by seizures, memory deficits, increased anxiety and mood dysregulation. In some patients it is associated with small–cell lung cancer and with other autoantibodies. We are presenting a case of GABAb receptor autoimmune encephalitis which was associated with non–malignant lung lesion, likely inflammatory in nature. A 62 year old woman presented with recent onset depression and tonic–clonic seizures. CT head showed patchy white matter changes particularly in the left frontal lobe. Initial treatment for suspected infecti...
Source: Journal of Neurology, Neurosurgery and Psychiatry - October 9, 2013 Category: Neurosurgery Authors: Wysota, B., Teare, L., Karim, A., Jacob, S. Tags: Immunology (including allergy), Epilepsy and seizures, Infection (neurology), Stroke, Drugs: psychiatry, Memory disorders (psychiatry), Radiology, Drugs: musculoskeletal and joint diseases, Radiology (diagnostics) Association of British Neurologists (AB Source Type: research

Anti glutamic acid decarboxylase antibody mediated encephalopathy while on etanercept in a patient with multiple autoimmune diseases
A 39 year old lady presented with an altered mental state and unsteadiness of gait. She had a history of juvenile idiopathic arthritis, autoimmune thyroiditis and alopecia, protein S deficiency with vena cava thrombosis, previous excision of ovarian mass and vasculitic rash. There was a previous history of ovarian mass and her immunomodulatory therapy for arthritis over the previous year was Etanercept. She used recreational cannabis but denied any other illicit drug usage. Her affect was variable and at times inappropriate with frequent laughter. She would spit regularly. There was anxiety and a prevailing sensation of do...
Source: Journal of Neurology, Neurosurgery and Psychiatry - October 9, 2013 Category: Neurosurgery Authors: MacDougall, N., Waddell, B., O'Riordan, J. I. Tags: Immunology (including allergy), Brain stem / cerebellum, Drugs: CNS (not psychiatric), Epilepsy and seizures, Infection (neurology), Stroke, Drugs misuse (including addiction), Connective tissue disease, Musculoskeletal syndromes Association of British Source Type: research

{Delta}9-TETRAHYDROCANNABINOL IS PROTECTIVE THROUGH PPAR{gamma} DEPENDENT MITOCHONDRIAL BIOGENESIS IN A CELL CULTURE MODEL OF PARKINSON'S DISEASE
Conclusions Even though 9–THC and pioglitazone are both protective against MPP+ only 9–THC induces PPAR dependent mitochondrial biogenesis, a mechanism that may be beneficial for the treatment of PD.
Source: Journal of Neurology, Neurosurgery and Psychiatry - October 9, 2013 Category: Neurosurgery Authors: Zeissler, M.-L., Eastwood, J., Oliver Hanemann, C., Zajicek, J., Carroll, C. Tags: Immunology (including allergy), Drugs: CNS (not psychiatric), Parkinson's disease, Stroke Association of British Neurologists (ABN) joint meeting with the Royal College of Physicians (RCP), London, 23-24 October 2013 Source Type: research

Grey matter and csf amyloid in early non-demented parkinson's disease: the incidence of cognitive impairment in cohorts with longitudinal evaluation in parkinson's disease (icicle-pd) study
Conclusion We report a significant correlation between reduced GM volume and lower Aβ1–40 and Aβ1–42 levels in patients with newly diagnosed PDND. These data suggest that even in early PD, CSF markers may be associated with measures of brain atrophy. Although neither GM loss nor Aβ1–40 or Aβ1–42 levels correlated with cognitive performance, we postulate that this reflects the very early nature of the neurodegenerative process in this cohort.
Source: Journal of Neurology, Neurosurgery and Psychiatry - October 9, 2013 Category: Neurosurgery Authors: Duncan, G. W., Yarnall, A. J., Firbank, M. J., Barker, R. A., O'Brien, J. T., Burn, D. J. Tags: Dementia, Drugs: CNS (not psychiatric), Parkinson's disease, Stroke, Memory disorders (psychiatry) Association of British Neurologists (ABN) joint meeting with the Royal College of Physicians (RCP), London, 23-24 October 2013 Source Type: research

Grey matter correlations of cognitive impairment in early parkinson's disease: the incidence of cognitive impairment in cohorts with longitudinal evaluation-parkinson's disease (icicle-pd) study
Conclusion GM loss is not present in newly diagnosed PD, either in patients with PD–MCI or PD–NC. These data are consistent with neuropathological studies suggesting that GM loss occurs with disease progression and is not prominent in early PD where the neurodegenerative process is more limited.
Source: Journal of Neurology, Neurosurgery and Psychiatry - October 9, 2013 Category: Neurosurgery Authors: Duncan, G. W., Firbank, M. J., Yarnall, A. J., Barker, R. A., O'Brien, J. T., Burn, D. J. Tags: Dementia, Drugs: CNS (not psychiatric), Parkinson's disease, Stroke, Memory disorders (psychiatry), Radiology, Radiology (diagnostics) Association of British Neurologists (ABN) joint meeting with the Royal College of Physicians (RCP), London, 23-24 Octo Source Type: research

Using 'dead or dependent' as an outcome measure in parkinson's disease clinical trials
Conclusion ‘Death or dependency’ is a feasible and potentially important new composite outcome measure for PD trials, including neuroprotective trials, although more work needs to be done to confirm this.
Source: Journal of Neurology, Neurosurgery and Psychiatry - October 9, 2013 Category: Neurosurgery Authors: McGhee, D., Parker, A., Fielding, S., Counsell, C. Tags: Drugs: CNS (not psychiatric), Parkinson's disease, Stroke Association of British Neurologists (ABN) joint meeting with the Royal College of Physicians (RCP), London, 23-24 October 2013 Source Type: research

Which clinical measures are most appropriate for measuring disease progression in parkinson's disease?
Conclusions Collection of all examined clinical measures was feasible. The PDQ–39 summary index and subsections were most sensitive to change.
Source: Journal of Neurology, Neurosurgery and Psychiatry - October 9, 2013 Category: Neurosurgery Authors: McGhee, D., Parker, A., Fielding, S., Counsell, C. Tags: Drugs: CNS (not psychiatric), Parkinson's disease, Stroke Association of British Neurologists (ABN) joint meeting with the Royal College of Physicians (RCP), London, 23-24 October 2013 Source Type: research

Think outside the box, collapse the box, and take a sharp knife to it!
A 74 year–old woman presented in December 2011 with left sided cerebellar symptoms. She was initially diagnosed as having a posterior circulation infarction and discharged from hospital on appropriate medication. However, over the following month she continued to deteriorate, developing increasing unsteadiness, falls, nausea and vomiting. Following a second admission in January 2012 she had a single seizure and developed focal left sided myoclonus affecting mainly the upper limb. Over the following month the myoclonus spread to affect all four limbs, although it remained more prominent on the left side. There was evi...
Source: Journal of Neurology, Neurosurgery and Psychiatry - October 9, 2013 Category: Neurosurgery Authors: Dobson, R., McMillan, A., Kung, K., Thom, M., Davis, A., Simister, R., Giovannoni, G., Gnanapavan, S. Tags: Immunology (including allergy), HIV/AIDS, Tropical medicine (infectious diseases), Brain stem / cerebellum, Epilepsy and seizures, Infection (neurology), Multiple sclerosis, Stroke, Ophthalmology, Radiology, Surgical diagnostic tests Association of Brit Source Type: research

Cannabinoid use in progressive inflammatory brain disease (cupid) mri sub-study
Conclusion 9–THC was not better than placebo at reducing the rates of new T1 or T2 lesions or brain atrophy in patients with progressive MS.
Source: Journal of Neurology, Neurosurgery and Psychiatry - October 9, 2013 Category: Neurosurgery Authors: Mallik, S., Ball, S., Dalton, C., MacManus, D., Tozer, D., Miller, D., Zajicek, J. Tags: Immunology (including allergy), Drugs: CNS (not psychiatric), Multiple sclerosis, Stroke, Radiology, Drugs: musculoskeletal and joint diseases, Radiology (diagnostics) Association of British Neurologists (ABN) joint meeting with the Royal College of Phy Source Type: research

Electrolyte imbalance triggering relapse of inflammatory neuropathy
We describe a case of a 71 year old female with a fourteen year history of chronic inflammatory demyelinating polyneuropathy (CIDP) and stable monoclonal gammopathy, normally maintained on three–weekly intravenous immunoglobulin (IVIG) therapy. At her best baseline, she has a normal motor examination and reduced vibration sense only to the ankles. She presented with a four week history of progressive numbness and paresthesiae in all four limbs, reduced balance, a decline in mobility with frequent falls and reduced hand function. The deterioration developed after a week of non–bloody diarrhoea with night sweats ...
Source: Journal of Neurology, Neurosurgery and Psychiatry - October 9, 2013 Category: Neurosurgery Authors: Keshavan, A., Gandhi, S., Lunn, M., Reilly, M. Tags: Neurogastroenterology, Immunology (including allergy), Drugs: CNS (not psychiatric), Multiple sclerosis, Neuromuscular disease, Peripheral nerve disease, Stroke, Hypertension Association of British Neurologists (ABN) joint meeting with the Royal College Source Type: research

Autologous mesenchymal stem cells for the treatment of secondary progressive multiple sclerosis: an open-label phase 2a proof-of-concept study
Conclusions Autologous MSCs can be safely administered in secondary progressive MS with evidence to suggest structural, functional and physiological improvement following treatment consistent with neuroprotection. The transient treatment response seen implied a likely requirement for repeat infusions to sustain benefit in the long–term.
Source: Journal of Neurology, Neurosurgery and Psychiatry - October 9, 2013 Category: Neurosurgery Authors: Connick, P., Chandran, S. Tags: Immunology (including allergy), Multiple sclerosis, Stroke, Ophthalmology Association of British Neurologists (ABN) joint meeting with the Royal College of Physicians (RCP), London, 23-24 October 2013 Source Type: research

Sodium accumulation is associated with disability and progression in multiple sclerosis: a 23na mri study
Conclusions Significant increases in sodium were seen in lesions and normal appearing brain tissues in MS. Increased concentration of sodium in lesions, cortical grey matter, NAWM and basal ganglia in SPMS versus RRMS indicates greater neuroaxonal metabolic dysfunction and/or loss in the former group. MRI measurement of sodium concentration in vivo is likely to reflect clinically relevant neuroaxonal pathophysiology and may be a useful outcome measure in trials of putative neuroprotective treatments.
Source: Journal of Neurology, Neurosurgery and Psychiatry - October 9, 2013 Category: Neurosurgery Authors: Paling, D., Solanky, B., Riemer, F., Tozer, D., Wheeler-Kingshott, C., Kapoor, R., Golay, X., Miller, D. Tags: Immunology (including allergy), Multiple sclerosis, Stroke, Radiology, Radiology (diagnostics) Association of British Neurologists (ABN) joint meeting with the Royal College of Physicians (RCP), London, 23-24 October 2013 Source Type: research

Longitudinal research into alzheimer's disease, fronto-temporal dementia and other dementias
Conclusion The BNSU provides an easy method of referral of patients with dementia for their inclusion in research.
Source: Journal of Neurology, Neurosurgery and Psychiatry - October 9, 2013 Category: Neurosurgery Authors: Rossor, M., Ahmed, R., Liang, Y., Douglas, J., Mahoney, C., Warren, J., Schott, J., Fox, N. Tags: Dementia, Drugs: CNS (not psychiatric), Motor neurone disease, Neuroimaging, Neuromuscular disease, Stroke, Memory disorders (psychiatry), Psychiatry of old age Association of British Neurologists (ABN) joint meeting with the Royal College of Physicians Source Type: research

'the mind is its own place': amelioration of claustrophobia in a patient with semantic dementia
Specific phobia is defined as marked, persistent and excessive or unreasonable fear when in the presence of, or when anticipating an encounter with, a specific object or situation.1 Here we describe amelioration of one common and disabling example, claustrophobia, following the onset of semantic dementia. Our patient had a clinical diagnosis of claustrophobia dating from her 20s and severe enough to cause her difficulties in daily life. She had habitually avoided lifts, windowless rooms, train travel and flying on account of her intense fear of being enclosed. At the age of 61, she developed a typical syndrome of semantic ...
Source: Journal of Neurology, Neurosurgery and Psychiatry - October 9, 2013 Category: Neurosurgery Authors: Clarke, C., Fletcher, P., Cifelli, A., Warren, J. Tags: Dementia, Neuroimaging, Stroke, Anxiety disorders (including OCD and PTSD), Memory disorders (psychiatry), Radiology, Radiology (diagnostics) Association of British Neurologists (ABN) joint meeting with the Royal College of Physicians (RCP), London, 23- Source Type: research

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