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Innovative Magnetic Resonance Imaging Markers of Hereditary Cerebral Amyloid Angiopathy at 7 Tesla Brief Report
Background and Purpose—The aim of the present study is to explore whether using 7 Tesla magnetic resonance imaging, additional brain changes can be observed in hereditary cerebral hemorrhage with amyloidosis-Dutch type (HCHWA-D) patients as compared with the established magnetic resonance imaging features of sporadic cerebral amyloid angiopathy.Methods—The local institutional review board approved this prospective cohort study. In all cases, informed consent was obtained. This prospective parallel cohort study was conducted between 2012 and 2014. We performed T2*-weighted magnetic resonance imaging performed at 7 Tesla...
Source: Stroke - May 25, 2018 Category: Neurology Authors: Emma A. Koemans, Ellis S. van Etten, Anna M. van Opstal, Gerda Labadie, Gisela M. Terwindt, Marieke J.H. Wermer, Andrew G. Webb, Edip M. Gurol, Steven M. Greenberg, Mark A. van Buchem, Jeroen van der Grond, Sanneke van Rooden Tags: Magnetic Resonance Imaging (MRI), Cerebrovascular Disease/Stroke, Intracranial Hemorrhage, Vascular Disease Brief Reports Source Type: research

Increased Risk of Pregnancy Complications After Stroke Clinical Sciences
Background and Purpose—The study goal was to investigate the prevalence of pregnancy complications and pregnancy loss in women before, during, and after young ischemic stroke/transient ischemic attack.Methods—In the FUTURE study (Follow-Up of Transient Ischemic Attack and Stroke Patients and Unelucidated Risk Factor Evaluation), a prospective young stroke study, we assessed the occurrence of pregnancy, miscarriages, and pregnancy complications in 223 women aged 18 to 50 years with a first-ever ischemic stroke/transient ischemic attack. Pregnancy complications (gestational hypertension, diabetes mellitus, preeclampsia, ...
Source: Stroke - March 26, 2018 Category: Neurology Authors: Mayte E. van Alebeek, Myrthe de Vrijer, Renate M. Arntz, Noortje A.M.M. Maaijwee, Nathalie E. Synhaeve, Hennie Schoonderwaldt, Maureen J. van der Vlugt, Ewoud J. van Dijk, Roel de Heus, Loes C.A. Rutten-Jacobs, Frank-Erik de Leeuw Tags: Cerebrovascular Disease/Stroke, Ischemic Stroke Original Contributions Source Type: research

Utility-Weighted Modified Rankin Scale as Primary Outcome in Stroke Trials Clinical Sciences
Conclusions—The UW-mRS as primary outcome does not capture individual variation in utility values and may reduce the statistical power of a randomized trial.
Source: Stroke - March 26, 2018 Category: Neurology Authors: Simone A. Dijkland, Daphne C. Voormolen, Esmee Venema, Bob Roozenbeek, Suzanne Polinder, Juanita A. Haagsma, Daan Nieboer, Vicky Chalos, Albert J. Yoo, Jennifer Schreuders, Aad van der Lugt, Charles B.L.M. Majoie, Yvo B.W.E.M. Roos, Wim H. van Zwam, Rober Tags: Quality and Outcomes, Cerebrovascular Disease/Stroke Original Contributions Source Type: research

Associations Between Collateral Status and Thrombus Characteristics and Their Impact in Anterior Circulation Stroke Clinical Sciences
Conclusions—Patients with lower thrombus burden and higher thrombus perviousness scores had higher collateral score. The positive effect of thrombus perviousness on clinical outcome was only present in patients with moderate and high collateral scores.Clinical Trial Registration—URL: http://www.trialregister.nl. Unique identifier: NTR1804 and URL: http://www.controlled-trials.com Unique identifier: ISRCTN10888758.
Source: Stroke - January 22, 2018 Category: Neurology Authors: Heitor C. Alves, Kilian M. Treurniet, Bruna G. Dutra, Ivo G. H. Jansen, Anna M.M. Boers, Emilie M.M. Santos, Olvert A. Berkhemer, Diederik W.J. Dippel, Aad van der Lugt, Wim H. van Zwam, Robert J. van Oostenbrugge, Hester F. Lingsma, Yvo B.W.E.M. Roos, Al Tags: Computerized Tomography (CT), Ischemic Stroke Original Contributions Source Type: research

Intracranial Aneurysm-Associated Single-Nucleotide Polymorphisms Alter Regulatory DNA in the Human Circle of Willis Basic Science
Conclusions—CoW regulatory regions link IA-associated SNPs to genes with a potential role in the development of IAs. Our data refine previous predictions on SNPs associated with IA and provide a substantial resource from which candidates for follow-up studies can be prioritized.
Source: Stroke - January 22, 2018 Category: Neurology Authors: Melanie D. Laarman, Marit W. Vermunt, Rachel Kleinloog, Jelkȷe J. de Boer–Bergsma, Netherlands Brain Bank, Gabriel J.E. Rinkel, Menno P. Creyghton, Michal Mokry, Jeroen Bakkers, Ynte M. Ruigrok Tags: Computational Biology, Epigenetics, Gene Expression & Regulation, Cerebral Aneurysm, Intracranial Hemorrhage Original Contributions Source Type: research

Circulating Endothelial Markers in Retinal Vasculopathy With Cerebral Leukoencephalopathy and Systemic Manifestations Clinical Sciences
Background and Purpose—Retinal vasculopathy with cerebral leukoencephalopathy and systemic manifestations (RVCL-S) is a monogenic small vessel disease, caused by C-terminal truncating TREX1 mutations, that can be considered a model for stroke and vascular dementia. The pathophysiology of RVCL-S is largely unknown, but systemic endothelial involvement has been suggested, leading to pathology in the brain and other highly vascularized organs. Here, we investigated circulating endothelial markers to confirm endothelial involvement and identify biomarkers for disease activity.Methods—We measured circulating levels of von W...
Source: Stroke - November 27, 2017 Category: Neurology Authors: Nadine Pelzer, Roel Bijkerk, Marlies E.J. Reinders, Anton Jan van Zonneveld, Michel D. Ferrari, Arn M.J.M. van den Maagdenberg, Jeroen Eikenboom, Gisela M. Terwindt Tags: Biomarkers, Endothelium/Vascular Type/Nitric Oxide, Genetics, Cerebrovascular Disease/Stroke Original Contributions Source Type: research

Association of Computed Tomography Ischemic Lesion Location With Functional Outcome in Acute Large Vessel Occlusion Ischemic Stroke Clinical Sciences
Conclusions—The association between follow-up noncontrast computed tomography ILV and outcome as assessed with mRS 3 months after stroke is strengthened by accounting for the mRS relevance of the affected brain areas. Future prediction models should account for the ILV in brain areas of high mRS relevance.
Source: Stroke - August 28, 2017 Category: Neurology Authors: Marielle Ernst, Anna M.M. Boers, Annette Aigner, Olvert A. Berkhemer, Albert J. Yoo, Yvo B. Roos, Diederik W.J. Dippel, Aad van der Lugt, Robert J. van Oostenbrugge, Wim H. van Zwam, Jens Fiehler, Henk A. Marquering, Charles B.L.M. Majoie Tags: Ischemic Stroke Original Contributions Source Type: research

Prediction of Clinical Outcome After Acute Ischemic Stroke Brief Report
Conclusions—Follow-up imaging after 3 days improves outcome prediction compared with prediction based on baseline variables alone. CTA recanalization and CTP reperfusion do not outperform noncontrast CT at this time point.Clinical Trial Registration—URL: http://www.clinicaltrials.gov. Unique identifier: NCT00880113.
Source: Stroke - August 28, 2017 Category: Neurology Authors: Jan W. Dankbaar, Alexander D. Horsch, Andor F. van den Hoven, L. Jaap Kappelle, Irene C. van der Schaaf, Tom van Seeters, Birgitta K. Velthuis Tags: Computerized Tomography (CT), Prognosis, Ischemic Stroke Brief Reports Source Type: research

Letter by Freeman Regarding Article, “Baseline Blood Pressure Effect on the Benefit and Safety of Intra-Arterial Treatment in MR CLEAN (Multicenter Randomized Clinical Trial of Endovascular Treatment of Acute Ischemic Stroke in the Netherlands)” Letter to the Editor
Source: Stroke - July 24, 2017 Category: Neurology Authors: William D. Freeman Tags: Treatment, Ischemic Stroke Letters to the Editor Source Type: research

Response by Mulder et al to Letter Regarding Article, “Baseline Blood Pressure Effect on the Benefit and Safety of Intra-Arterial Treatment in MR CLEAN (Multicenter Randomized Clinical Trial of Endovascular Treatment of Acute Ischemic Stroke in the Netherlands)” Letter to the Editor
Source: Stroke - July 24, 2017 Category: Neurology Authors: Maxim J.H.L. Mulder, Hester F. Lingsma, Diederik W.J. Dippel Tags: High Blood Pressure, Revascularization, Cerebrovascular Disease/Stroke, Ischemic Stroke Letters to the Editor Source Type: research

Ethnic Disparities in Ischemic Stroke, Intracerebral Hemorrhage, and Subarachnoid Hemorrhage Incidence in The Netherlands Clinical Sciences
Conclusions— Our findings suggest that Surinamese have an increased risk, whereas Moroccans have a reduced risk for all the various stroke subtypes. Among other ethnic minorities, the risk seems to depend on the stroke subtype and sex. These findings underscore the need to identify the root causes of these ethnic differences to assist primary and secondary prevention efforts.
Source: Stroke - October 27, 2014 Category: Neurology Authors: Agyemang, C., van Oeffelen, A. A. M., Norredam, M., Kappelle, L. J., Klijn, C. J. M., Bots, M. L., Stronks, K., Vaartjes, I. Tags: Cerebrovascular disease/stroke Clinical Sciences Source Type: research

Incidence of Oral Anticoagulant-Associated Intracerebral Hemorrhage in the Netherlands Brief Reports
Conclusions— The annual incidences of ICH and OAC-ICH are relatively high in the Netherlands when compared with international literature.
Source: Stroke - December 23, 2013 Category: Neurology Authors: Schols, A. M. R., Schreuder, F. H. B. M., van Raak, E. P. M., Schreuder, T. H. C. M. L., Rooyer, F. A., van Oostenbrugge, R. J., Staals, J. Tags: Coumarins, Acute Cerebral Hemorrhage Brief Reports Source Type: research