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Budget impact of endovascular treatment for acute ischaemic stroke patients in the Netherlands for 2015-2021
CONCLUSION: Offering EVT as add-on to usual care for acute ischaemic stroke patients was increasingly cost saving from a national healthcare perspective but affected distinct healthcare sectors differently.PMID:37171711 | DOI:10.1007/s12471-023-01788-x
Source: Atherosclerosis - May 12, 2023 Category: Cardiology Authors: Lucie A van den Berg Olvert A Berkhemer Puck S S Fransen Debbie Beumer Charles B L Majoie Diederik W J Dippel Aad van der Lugt Robert J van Oostenbrugge Wim H van Zwam Yvo B Roos Marcel G W Dijkgraaf MR CLEAN investigators Source Type: research

Inadequate response to antiplatelet therapy in patients with peripheral artery disease: a prospective cohort study
CONCLUSIONS: Patients suffering from cardiovascular events and mortality were characterized by prior cardiovascular events as compared to patients who did not experience any events. Antiplatelet therapy was not optimally protective despite high medication adherence, and HTPR was independently associated with the occurrence of events. More research is needed on alternative treatment strategies such as dual antiplatelet therapy or combinations with anticoagulant drugs.TRIAL REGISTRATION: The Medical Ethics Committee (METC) of the MUMC+ approved the study (NL63235.068.17) and the study was registered in the Netherlands Trial ...
Source: Atherosclerosis - January 10, 2023 Category: Cardiology Authors: B M M Kremers J H C Daemen H Ten Cate H M H Spronk B M E Mees A J Ten Cate-Hoek Source Type: research

Management of extracranial carotid artery stenosis during endovascular treatment for acute ischaemic stroke: results from the MR CLEAN Registry
CONCLUSIONS: Functional outcomes were comparable after EVT with and without CAS. CAS during EVT might be a feasible option to treat the extracranial ICA stenosis but randomised studies are warranted to prove non-inferiority or superiority.PMID:36572506 | DOI:10.1136/svn-2022-001891
Source: Atherosclerosis - December 26, 2022 Category: Cardiology Authors: Sabine L Collette Michael P Rodgers Marianne A A van Walderveen Kars C J Compagne Paul J Nederkoorn Jeannette Hofmeijer Jasper M Martens Gert J de Borst Gert Jan R Luijckx Charles B L M Majoie Aad van der Lugt Reinoud P H Bokkers Maarten Uyttenboogaart MR Source Type: research

Trigger Factors for Stroke in Young Adults: A Case-Crossover Study
DISCUSSION: We identified cola consumption, vigorous physical exercise, sexual activity, illicit drug use, fever- and flu-like disease as potential trigger factors for stroke in the young, and found differences in type and number of trigger factors associated with different etiologic subgroups of ischemic stroke. These findings might help in better understanding the pathophysiological mechanisms of (cryptogenic) stroke in the young.PMID:36127143 | DOI:10.1212/WNL.0000000000201341
Source: Atherosclerosis - September 20, 2022 Category: Cardiology Authors: Merel S Ekker Jamie Inge Verhoeven Karlijn Rensink Mijntje M I Schellekens Esther Boot Mayte van Alebeek Paul J A M Brouwers Renate Arntz Gert W van Dijk Rob A R Gons Inge van Uden Tom den Heijer Paul de Kort Karlijn de Laat Anouk Gw van Norden Sarah Verm Source Type: research

Etiology of Large Vessel Occlusion Posterior Circulation Stroke: Results of the MR CLEAN Registry
CONCLUSIONS: Unlike the anterior circulation, most frequent cause in our posterior large vessel occlusion stroke cohort is LAA followed by cardioembolism, dissection, and ESUS. Patients with cardioembolism and ESUS have a better prognosis for functional outcome after endovascular thrombectomy than patients with LAA.PMID:35543130 | DOI:10.1161/STROKEAHA.121.038054
Source: Atherosclerosis - May 11, 2022 Category: Cardiology Authors: F A V Anne Pirson Nikki Boodt Josje Brouwer Agnetha A E Bruggeman Wouter H Hinsenveld Julie Staals Wim H van Zwam Christiaan van der Leij Rutger J B Brans Charles B L M Majoie Diederik W J Dippel Aad van der Lugt Wouter J Schonewille Robert J van Oostenbr Source Type: research

Endovascular Thrombectomy in Young Patients With Stroke: A MR CLEAN Registry Study
CONCLUSIONS: Ten percent of patients with acute ischemic stroke undergoing endovascular thrombectomy were younger than 50. Cardioembolism and carotid dissection were common underlying causes in young patients. In one-third of cases, no cause was identified, indicating the need for more research on stroke cause in young patients. Young patients had better prognosis and lower risk of symptomatic intracranial hemorrhage than older patients.PMID:34872339 | DOI:10.1161/STROKEAHA.120.034033
Source: Atherosclerosis - December 7, 2021 Category: Cardiology Authors: Josje Brouwer Johanna A Smaal Bart J Emmer Inger R de Ridder Ido R van den Wijngaard Frank-Erik de Leeuw Jeannette Hofmeijer Wim H van Zwam Jasper M Martens Yvo B W E M Roos Charles B Majoie Robert J van Oostenbrugge Jonathan M Coutinho MR CLEAN Registry Source Type: research