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Percutaneous atrial shunt closure and the risk of recurrent ischemic stroke: A register-based, nationwide cohort study
Patent foramen ovale may cause paradoxical emboli1. Cryptogenic ischemic cerebrovascular events (stroke or transient ischemic attack) (CVE) accounts for about 25% of ischemic strokes.2,3 Transcatheter closure of atrial shunts, including atrial septal defects (ASD) and patent foramen ovale (PFO), was introduced in 1996.4-6 Initially,randomized studies failed7-9 but more recent randomized studies have shown superiority of interventional treatment, with 68 % reduction of recurrent stroke after transcatheter closure of PFO compared with medical treatment in patients with cryptogenic CVE.
Source: Journal of Stroke and Cerebrovascular Diseases - March 23, 2023 Category: Neurology Authors: Alexia Karagianni, Zacharias Mandalenakis, Savvas Papadopoulos, Mikael Dellborg, Peter Eriksson Source Type: research

Risk of recurrent ischemic stroke in patients with patent foramen ovale: The role of D-dimer
Paradoxical embolism under elevated thromboembolic conditions is known to be the primary mechanism of patent foramen ovale (PFO)-related stroke. We hypothesized that higher levels of D-dimer, a marker of thromboembolism, could increase the risk of stroke recurrence in patients with PFO.
Source: Journal of Stroke and Cerebrovascular Diseases - August 1, 2023 Category: Neurology Authors: Seongho Park, Boseong Kwon, Jin Kyung Oh, Jae-Kwan Song, Ji Sung Lee, Sun U. Kwon Source Type: research

Recurrent Stroke due to Patent Foramen Ovale Closure Device Thrombus Eight Years after Implantation
We present a case of cardioembolic stroke secondary to a mobile thrombus on a PFO closure device 8 years after implantation.
Source: Journal of Stroke and Cerebrovascular Diseases - July 17, 2016 Category: Neurology Authors: Thomas V. Kodankandath, Sanskriti Mishra, Richard B. Libman, Paul Wright Tags: Case Studies Source Type: research

Thrombolysis for Ischemic Stroke during Pregnancy: A Case Report and Review of the Literature
We report the successful use of intravenous alteplase (tissue plasminogen activator; tPA) thrombolysis in a pregnant woman with acute cardioembolic stroke presumed to be paradoxical embolism through a patent foramen ovale.
Source: Journal of Stroke and Cerebrovascular Diseases - August 10, 2016 Category: Neurology Authors: Steven Tversky, Richard B. Libman, Marina L. Reppucci, Andrea M. Tufano, Jeffrey M. Katz Tags: Case Studies Source Type: research

Tissue Plasminogen Activator to Treat a Stroke after Foam Sclerotherapy in a Woman with a Patent Foramen Ovale
Although foam sclerotherapy to varicose veins is now a popular treatment because of its high efficacy and safety, some neurologic complications have recently been reported. Presently, the effectiveness and safety of intravenous recombinant tissue-type plasminogen activator therapy to stroke following foam sclerotherapy remain unclear. Here, we report the case of a 68-year-old woman whose ischemic symptoms following foam sclerotherapy were treated by intravenous recombinant tissue-type plasminogen activator.
Source: Journal of Stroke and Cerebrovascular Diseases - February 2, 2018 Category: Neurology Authors: Kosuke Matsuzono, Naoto Arai, Masayuki Suzuki, Younhee Kim, Tadashi Ozawa, Takafumi Mashiko, Haruo Shimazaki, Reiji Koide, Tohru Matsuura, Shigeru Fujimoto Tags: Case Studies Source Type: research

Carotid Atherosclerosis and Patent Foramen Ovale in Embolic Stroke of Undetermined Source
Carotid atherosclerosis and likely pathogenic patent foramen ovale (PFO) are two potential embolic sources in patients with embolic stroke of undetermined source (ESUS). The relationship between these two mechanisms among ESUS patients remains unclear.
Source: Journal of Stroke and Cerebrovascular Diseases - October 30, 2020 Category: Neurology Authors: George Ntaios, Dimitrios Sagris, Davide Strambo, Kalliopi Perlepe, Gaia Sirimarco, Georgios Georgiopoulos, Stefania Nannoni, Eleni Korompoki, Efstathios Manios, Konstantinos Makaritsis, Konstantinos Vemmos, Patrik Michel Source Type: research

Cardiac and Echocardiographic Markers in Cryptogenic Stroke with Incidental Patent Foramen Ovale
Some cardiac abnormalities could be a substrate for potential embolic source in cryptogenic stroke (CS). We evaluated whether cardiac and echocardiographic markers were associated with CS in patients with incidental patent foramen ovale (PFO) as defined using the Risk of Paradoxical Embolism (RoPE) score.
Source: Journal of Stroke and Cerebrovascular Diseases - June 6, 2021 Category: Neurology Authors: Yohei Tateishi, Yuji Ueno, Akira Tsujino, Ayako Kuriki, Yuki Kamiya, Takahiro Shimizu, Ryosuke Doijiri, Eriko Yamaguchi, Muneaki Kikuno, Yoshiaki Shimada, Hidehiro Takekawa, Masatoshi Koga, Masafumi Ihara, Koichi Hirata, Yasuhiro Hasegawa, Kazunori Toyoda Source Type: research

Simultaneously Occurring Ischemic Stroke, Leg Artery Occlusion, and Pulmonary Embolism Induced by a Uterine Myoma
Paradoxical embolism from venous thrombosis through the patent foramen ovale is a rare but well-known cause of stroke in young adults. Here, we report a case of simultaneous middle cerebral artery infarction, multiple occlusions of the leg arteries, and pulmonary thromboembolism from the venous thrombus, all due to compression of the external iliac vein by a uterine leiomyoma.
Source: Journal of Stroke and Cerebrovascular Diseases - February 3, 2022 Category: Neurology Authors: Jean Hee Kim, Jaseong Koo, Kijeong Lee Tags: Case Report Source Type: research

Ipsilateral Carotid Plaque Presence is Inversely Associated with Patent Foramen Ovale in Cryptogenic Stroke: A Multicenter CohortStudy
Embolic stroke of undetermined source (ESUS) accounts for up to  20% of all strokes. Potential contributors to ESUS include patent foramen ovale (PFO) and non-stenotic plaque (
Source: Journal of Stroke and Cerebrovascular Diseases - June 21, 2022 Category: Neurology Authors: Anvitha Sathya, Thanh N. Nguyen, Sahily Reyes-Esteves, Scott Kamen, Taryn Hester, Nicholas Vigilante, John Woo, Linda Zhang, Mohamad Abdalkader, Brett Cucchiara, James E. Siegler Tags: Short Communication Source Type: research

Diagnosis of atrial fibrillation in young patients with ischemic stroke: A systematic review and meta-analysis
The recommended cardiac rhythm evaluation to determine the etiology of ischemic stroke (IS) is similar in all patients regardless of their age and includes an electrocardiogram and at least a 24-hour heart rhythm monitoring. However, it is known that the main causes of IS vary according to patients ’ age. There is a higher preponderance of arterial dissections and patent foramen ovale in younger patients, while atrial fibrillation (AF) is more common in older patients.
Source: Journal of Stroke and Cerebrovascular Diseases - August 30, 2023 Category: Neurology Authors: Joana V ítor, Gonçalo V. Bonifácio, Ana Catarina Fonseca Source Type: research

Clinical Outcomes after Intravenous Fibrinolysis in Cryptogenic Strokes with or without Patent Foramen Ovale
Conclusions: Paradoxical strokes had better outcomes after IV fibrinolysis than other ischemic stroke subtypes, but this difference is attributable to younger age and milder stroke severity on presentation.
Source: Journal of Stroke and Cerebrovascular Diseases - July 19, 2013 Category: Neurology Authors: Jason J. Chang, Tracy Chiem, Yazan J. Alderazi, Kristina Chapple, Lucas Restrepo Tags: Original Articles Source Type: research

Assessment of Morphology of Patent Foramen Ovale with Transesophageal Echocardiography in Symptomatic and Asymptomatic Patients
The frequency of patent foramen ovale (PFO) is greater in patients who have had a stroke and transient ischemic attack (TIA) than that in the general population. However, it is not well defined, which PFO would cause stroke or TIA. In this trial, we aimed to evaluate whether there was a difference regarding morphologic features of PFO in patients who were symptomatic (cryptogenic stroke or history of TIA) or asymptomatic according to the neurologic findings.
Source: Journal of Stroke and Cerebrovascular Diseases - April 20, 2015 Category: Neurology Authors: Nermin Bayar, Şakir Arslan, Göksel Çağırcı, Zehra Erkal, Çağın Mustafa Üreyen, Serkan Çay, Erkan Köklü, İsa Öner Yüksel, Selçuk Küçükseymen Source Type: research

Cerebral Infarction in a Case of Parry-Romberg Syndrome
Our objective is to report a rare coexistence of Parry-Romberg disease and ischemic stroke. Here, we report the case of a 34-year-old woman with Parry-Romberg syndrome who developed cerebral infarction. This patient developed sudden left-sided weakness and was admitted to our hospital. Magnetic resonance imaging revealed acute cerebral infarction in the posterior limb of the right internal capsule. The patient had been diagnosed with Parry-Romberg syndrome at the age of 12, and she had a history of migraine without aura. Transesophageal echocardiography revealed a patent foramen ovale, but no atrial septal aneurysm or deep...
Source: Journal of Stroke and Cerebrovascular Diseases - May 9, 2013 Category: Neurology Authors: Yuji Tomizawa, Ryota Tanaka, Kiyoshi Sekiguchi, Yutaka Oji, Yasutaka Tanaka, Kazuo Yamashiro, Nobutaka Hattori Tags: Case Reports Source Type: research

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