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Molecular cloning, prokaryotic expression and the anti-inflammatory activity of porcine PRDX5
In this study, the full-length cDNA encoding porcine PRDX5 (pPRDX5) was cloned. Subsequently, using porcine alveolar macrophages (PAMs), the target cells of PRRSV infection in vivo, we found that the recombinant pPRDX5 protein inhibited inflammatory responses induced by tumor necrosis factor alpha (TNF-α) or porcine reproductive and respiratory syndrome virus (PRRSV), a virus causing severe interstitial pneumonia in pigs. By contrast, knockdown of endogenous pPRDX5 with specific siRNA enhanced inflammatory responses induced by TNF-α or PRRSV. We also demonstrated that the involvement of pPRDX5 in inflammation regulation ...
Source: Developmental and Comparative Immunology - August 19, 2022 Category: Allergy & Immunology Authors: Panpan Ma Yanrong Zhou Puxian Fang Wenting Ke Shaobo Xiao Liurong Fang Source Type: research