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Proline ‐containing peptides—New insight and implications: A Review
AbstractThe family of regulatory proline ‐containing peptides (PCPs), also known as glyprolines, exhibit significant biological activity. The group of glyprolines includes Gly‐Pro (GP), Pro‐Gly‐Pro (PGP), cyclic Gly‐Pro (cGP), as well as PGP derivatives, for example, N‐acetylated PGP (N‐a‐PGP) and N‐methylated PGP (N‐m‐ PGP). PCPs are engaged in various biological processes including the proinflammatory neutrophil chemoattraction in lung diseases, inflammatory bowel diseases or ischemic stroke. Glyprolines have been also postulated to play an important role as atheroprotective and anticoagulant agents...
Source: BioFactors - August 19, 2019 Category: Biochemistry Authors: Magdalena Misiura, Wojciech Miltyk Tags: REVIEW ARTICLE Source Type: research