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Molecules, Vol. 27, Pages 2484: Beneficial Effects of Capsaicin in Disorders of the Central Nervous System
k Capsaicin is a natural compound found in chili peppers and is used in the diet of many countries. The important mechanism of action of capsaicin is its influence on TRPV1 channels in nociceptive sensory neurons. Furthermore, the beneficial effects of capsaicin in cardiovascular and oncological disorders have been described. Many recent publications show the positive effects of capsaicin in animal models of brain disorders. In Alzheimer’s disease, capsaicin reduces neurodegeneration and memory impairment. The beneficial effects of capsaicin in Parkinson’s disease and depression have also be...
Source: Molecules - April 12, 2022 Category: Chemistry Authors: Micha ł Pasierski Bart łomiej Szulczyk Tags: Review Source Type: research

Molecules, Vol. 23, Pages 3305: Overview on the Effects of N-Acetylcysteine in Neurodegenerative Diseases
azzon N-acetylcysteine (NAC), which is an acetylated cysteine compound, has aroused scientific interest for decades due to its important medical applications. It also represents a nutritional supplement in the human diet. NAC is a glutathione precursor and shows antioxidant and anti-inflammatory activities. In addition to the uses quoted in the literature, NAC may be considered helpful in therapies to counteract neurodegenerative and mental health diseases. Furthermore, this compound has been evaluated for its neuroprotective potential in the prevention of cognitive aging dementia. NAC is inexpensive, commercially avai...
Source: Molecules - December 13, 2018 Category: Chemistry Authors: Giuseppe Tardiolo Placido Bramanti Emanuela Mazzon Tags: Review Source Type: research

Molecules, Vol. 25, Pages 2719: Hormesis and Ginseng: Ginseng Mixtures and Individual Constituents Commonly Display Hormesis Dose Responses, Especially for Neuroprotective Effects
se This paper demonstrates that ginseng mixtures and individual ginseng chemical constituents commonly induce hormetic dose responses in numerous biological models for endpoints of biomedical and clinical relevance, typically providing a mechanistic framework. The principal focus of ginseng hormesis-related research has been directed toward enhancing neuroprotection against conditions such as Alzheimer’s and Parkinson’s Diseases, stroke damage, as well as enhancing spinal cord and peripheral neuronal damage repair and reducing pain. Ginseng was also shown to reduce symptoms of diabetes, prev...
Source: Molecules - June 10, 2020 Category: Chemistry Authors: Calabrese Tags: Review Source Type: research