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Inflammatory hypertrophic cauda equina following intrathecal neural stem cell injection
We describe a woman who presented with progressive bilateral leg pain, numbness, and gait difficulties. A prior stroke, macular degeneration, osteoarthritis, and depression, led her to receive intrathecal neural stem cell therapy overseas 1 year prior to onset of symptoms. Imaging showed marked enlargement of lumbosacral roots of the cauda equina, which was not seen prior to stem cell treatment. Electrodiagnostic studies confirmed chronic multiple lumbosacral radiculopathies. Biopsy of a lumbar dorsal sensory root showed myelinated fiber degeneration and loss, with endoneurial inflammation. The hypertrophic inflammatory ca...
Source: Muscle and Nerve - June 1, 2013 Category: Internal Medicine Authors: Richard W. Hurst, Jonathan M. Morris, P James B Dyck, E. Peter Bosch, Ronald K. Reeves Tags: Case of the Month Source Type: research

Inflammatory hypertrophic cauda equina syndrome following intrathecal neural stem cell injection
Conclusions: Safety of intrathecal stem cell treatments is not routinely regulated in commercial overseas stem cell facilities. We wish to bring this potential complication to the attention of health care providers. Muscle Nerve, 2013
Source: Muscle and Nerve - June 26, 2013 Category: Internal Medicine Authors: Richard W. Hurst, E. Peter Bosch, Jonathan M. Morris, P. James B. Dyck, Ronald K. Reeves Tags: Case of the Month Source Type: research

Small nerve fiber pathology in critical illness documented by serial skin biopsies
Discussion: Serial IENFD measurements confirmed the development of small fiber sensory involvement in the acute phase of critical illness. © 2014 Wiley Periodicals, Inc.
Source: Muscle and Nerve - October 12, 2014 Category: Internal Medicine Authors: Miroslav Skorna, Roman Kopacik, Eva Vlckova, Blanka Adamova, Milena Kostalova, Josef Bednarik Tags: Research Article Source Type: research

Small‐nerve‐fiber pathology in critical illness documented by serial skin biopsies
Conclusion: Serial IENFD measurements confirmed the development of small‐fiber sensory involvement in the acute phase of critical illness. Muscle Nerve, 2015
Source: Muscle and Nerve - May 29, 2015 Category: Internal Medicine Authors: Miroslav Skorna, Roman Kopacik, Eva Vlckova, Blanka Adamova, Milena Kostalova, Josef Bednarik Tags: Research Article Source Type: research