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Source: Journal of Allergy and Clinical Immunology
Condition: Pain

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Total 48 results found since Jan 2013.

Impact of EMR Intervention on Reducing Food Allergy Panel Testing
Indiscriminate food allergy (FA) screening can result in unnecessary food avoidance and anxiety. A retrospective chart review of 236 pediatric patients with FA testing at our institution revealed that the majority (76%) of testing was done for non-IgE mediated symptoms, such as chronic abdominal pain and behavioral issues.
Source: Journal of Allergy and Clinical Immunology - February 1, 2023 Category: Allergy & Immunology Authors: Jenika Ferretti-Gallon, Navdeep Riar, Suzanne Teuber, Anh Nguyen Source Type: research

Association of NSAID hypersensitivity with opioid prescribing following total joint arthroplasty
Nonsteroidal anti-inflammatory drugs (NSAIDs) are indicated for post-operative pain management, but medication use may be precluded by report of adverse drug reactions (ADRs). The impact of NSAID allergy labeling on opioid prescribing following total joint arthroplasty is unknown.
Source: Journal of Allergy and Clinical Immunology - February 1, 2023 Category: Allergy & Immunology Authors: Lily Li, Yuchiao Chang, Elena Losina, Karen Costenbader, Antonia Chen, Tanya Laidlaw Source Type: research

Neuro-immune communication regulating pruritus in atopic dermatitis
Atopic dermatitis (AD) is a common, chronic-relapsing inflammatory skin disease with significant disease burden. Genetic and environmental trigger factors contribute to AD, activating two of our largest organs, the nervous and immune system. Dysregulation of neuro-immune circuits plays a key role in the pathophysiology of AD causing inflammation, pruritus, pain, and barrier dysfunction. Sensory nerves can be activated by environmental or endogenous trigger factors transmitting itch stimuli to the brain.
Source: Journal of Allergy and Clinical Immunology - March 22, 2022 Category: Allergy & Immunology Authors: Martin Steinhoff, Fareed Ahmad, Atul Pandey, Angeliki Datsi, Ayda AlHammadi, Sara Al-Khawaga, Aysha Al-Malki, Jianghui Meng, Majid Alam, Joerg Buddenkotte Source Type: research

Neuroimmune communication regulating pruritus in atopic dermatitis
Atopic dermatitis (AD) is a common, chronic-relapsing inflammatory skin disease with significant disease burden. Genetic and environmental trigger factors contribute to AD, activating 2 of our largest organs, the nervous system and the immune system. Dysregulation of neuroimmune circuits plays a key role in the pathophysiology of AD, causing inflammation, pruritus, pain, and barrier dysfunction. Sensory nerves can be activated by environmental or endogenous trigger factors, transmitting itch stimuli to the brain.
Source: Journal of Allergy and Clinical Immunology - March 22, 2022 Category: Allergy & Immunology Authors: Martin Steinhoff, Fareed Ahmad, Atul Pandey, Angeliki Datsi, Ayda AlHammadi, Sara Al-Khawaga, Aysha Al-Malki, Jianghui Meng, Majid Alam, Joerg Buddenkotte Source Type: research

A connection found between mast cells and pain in eosinophilic esophagitis
Eosinophilic esophagitis (EoE) is a chronic inflammatory condition defined by ≥15 eosinophils per high-powered field (eos/hpf) with symptoms such as chest pain, and recent evidence of a concurrent mastocytosis. Mast cells (MCs) reside in peripheral tissue and communicate with nearby structures, including nerves. We hypothesized that MCs are associated with pain in EoE patie nts.
Source: Journal of Allergy and Clinical Immunology - February 1, 2022 Category: Allergy & Immunology Authors: Simin Zhang, Tetsuo Shoda, Seema Aceves, Mirna Chehade, Margaret Collins, Carla Davis, Evan Dellon, Gary Falk, Glenn Furuta, Nirmala Gonsalves, Sandeep Gupta, Ikuo Hirano, Paneez Khoury, John Leung, Kathryn Peterson, Jonathan Spergel, Joshua Wechsler, Gua Source Type: research

Assessment of Diagnostic Equivalence of Biological Secretions in Men with Chronic Prostatitis /Chronic Pelvic Pain
Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is a common treatment-resistant condition with symptoms of prostatitis, lack of evidence of a bacterial infection in expressed prostatic secretions, urine post-prostatic massage, or semen. When there is a high content of leukocytes in these secretions, an inflammatory ?PPS (National Institutes of Health (NIN) category IIIA) is diagnosed, whereas if they are normal a non-inflammatory CPPS (NIN category IIIB) is diagnosed.
Source: Journal of Allergy and Clinical Immunology - February 1, 2022 Category: Allergy & Immunology Authors: I. Gorpynchenko, K. Nurimanov, T. Poroshina, V. Savchenko, G. Drannik, Lawrence DuBuske Source Type: research

Survey of the Oral and Intestinal Microbiome in Patients with Systemic Mastocytosis
Systemic Mastocytosis (SM) is characterized by an aberrant expansion of clonal mast cells in specific tissues including the skin, marrow, liver, and the gastrointestinal tract, which may cause symptoms such as abdominal pain, diarrhea, and weight loss. Demonstration of an interplay between these manifestations and the GI and oral microbiome in patients with SM is of interest.
Source: Journal of Allergy and Clinical Immunology - February 1, 2022 Category: Allergy & Immunology Authors: Hirsh Komarow, Ayelet Makovoz, RIchard Rodrigues, Robin Eisch, Linda Scott, Dean Metcalfe Source Type: research

Type 2 inflammation changes airway nociceptors' transcriptome
Nociceptors, or pain neurons, have a pro-inflammatory role in allergic airway inflammation (AAI). They trigger cough reflexes, and release neuropeptides that promote vasodilation, mucus secretion and immune cells activation. However, the mechanisms driving this inflammatory phenotype in nociceptors are poorly understood.
Source: Journal of Allergy and Clinical Immunology - February 1, 2022 Category: Allergy & Immunology Authors: Theo Crosson, Jo-Chiao Wang, Katiane Roversi, Sebastien Talbot Source Type: research

Immune checkpoint skewing might be the cause of continuous immune activation in nasal polyps: New opportunities for therapies
Chronic rhinosinusitis (CRS) with or without nasal polyps is a localized major upper respiratory tract disease with an unknown cause. Initially, it resembles an infection that has gotten out of control and progressed into severe inflammation, eventually resulting in chronic sinusitis and nasal polyps. Patients with nasal polyps and sinusitis showed persistent symptoms, including nasal obstruction, loss of smell, nasal discharge, and facial pain or pressure, which are clinically the reasons for treating these patients.
Source: Journal of Allergy and Clinical Immunology - November 16, 2021 Category: Allergy & Immunology Authors: Alex KleinJan Tags: Editorial Source Type: research

Schnitzler Syndrome With Extremely Elevated IL-6 Responds To Anti IL-1 Receptor Antagonist
We previously reported Schnitzler Syndrome (SS) in a 73-year-old woman with extremely elevated levels of Il-6 and normal levels of IL-1 who responded to IL-6 receptor antagonists. SS is a rare autoinflammatory disorder, which is defined by two major criteria: chronic urticaria and monoclonal immunoglobulin M (IgM) or immunoglobulin G gammopathy, in combination with at least two of the following minor criteria: recurrent fever, joint and/or bone pain, leukocytosis and/or elevated C-reactive protein (CRP).
Source: Journal of Allergy and Clinical Immunology - February 1, 2021 Category: Allergy & Immunology Authors: Kevin Diehl, Zaynab Ashoor, Timothy Craig Source Type: research

Cytokines of Ejaculate from Men with Chronic Prostatitis/chronic Pelvic Pain Syndromes Treated by Extracorporeal Shockwave Therapy
Extracorporeal shockwave therapy (SWT) is non-pharmacological intervention for treating chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS). Dynamics of cytokines were assessed during treatment.
Source: Journal of Allergy and Clinical Immunology - February 1, 2021 Category: Allergy & Immunology Authors: I. Gorpynchenko, K. Nurimanov, T. Poroshina, V. Savchenko, G. Drannik, Lawrence Dubuske Source Type: research

The Prevalence of Hereditary Alpha-Tryptasemia in Patients Diagnosed With POTS via Tilt Table Testing
Autonomic disorders are reported at higher rates in patients with extra copies of the alpha-tryptase gene, known as hereditary alpha-tryptasemia (HaT). Clinical features of HaT include skeletal abnormalities, higher rates and severity of anaphylaxis, abdominal pain among others. HaT has not been reported in patients with basal serum tryptase (bST)
Source: Journal of Allergy and Clinical Immunology - February 1, 2021 Category: Allergy & Immunology Authors: Jenny Huang, Jose Criado Del Valle, Andrew White Source Type: research

Clinical characterization of skin pain in children with atopic dermatitis
We examined associations of skin pain intensity with clinical features and functional outcomes in pediatric AD.
Source: Journal of Allergy and Clinical Immunology - February 1, 2021 Category: Allergy & Immunology Authors: Brian Cheng, Amy Paller, James Griffith, Jonathan Silverberg, Anna Fishbein Source Type: research

Diagnosis of hereditary Angioedema by genetic mutation of coagulation factor XII
We present a patient who was referred to investigate for variants in exon 9 of F12 gene, and the mutation p.Thr328Lys was found in heterozygosity.
Source: Journal of Allergy and Clinical Immunology - February 1, 2021 Category: Allergy & Immunology Authors: Natasha Ferraroni, Gabriela Yoshimoto, Camila Veronez, Luiza Silva, Marina Batista, Bruna Azevedo, Jo ão Pesquero Source Type: research

Rituximab in the Treatment of Acquired Angioedema
Acquired visceral angioedema is rare and has many causes including allergic, NSAID-induced, hereditary C1 esterase deficiency, acei-induced, acquired angioedema, and idiopathic angioedema. A sixty-one-year old woman with a history of C. difficile colitis s/p fecal transplant started to have severe abdominal pain and imaging-supported visceral angioedema over 1 year. Her GI specialist checked C4 and C1 esterase and noted deficiency of both. Patient was referred for evaluation of acquired angioedema and treatment.
Source: Journal of Allergy and Clinical Immunology - February 1, 2021 Category: Allergy & Immunology Authors: Tracy Hwangpo Source Type: research