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APOE in the bullseye of neurodegenerative diseases: impact of the APOE genotype in Alzheimer's disease pathology and brain diseases
Mol Neurodegener. 2022 Sep 24;17(1):62. doi: 10.1186/s13024-022-00566-4.ABSTRACTApoE is the major lipid and cholesterol carrier in the CNS. There are three major human polymorphisms, apoE2, apoE3, and apoE4, and the genetic expression of APOE4 is one of the most influential risk factors for the development of late-onset Alzheimer's disease (AD). Neuroinflammation has become the third hallmark of AD, together with Amyloid-β plaques and neurofibrillary tangles of hyperphosphorylated aggregated tau protein. This review aims to broadly and extensively describe the differential aspects concerning apoE. Starting from the evolut...
Source: Molecular Medicine - September 24, 2022 Category: Molecular Biology Authors: Rosal ía Fernández-Calle Sabine C Konings Javier Fronti ñán-Rubio Juan Garc ía-Revilla Llu ís Camprubí-Ferrer Martina Svensson Isak Martinson Antonio Boza-Serrano Jos é Luís Venero Henrietta M Nielsen Gunnar K Gouras Tomas Deierborg Source Type: research
