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Lamotrigine for chronic neuropathic pain and fibromyalgia in adults.
CONCLUSIONS: Large, high-quality, long-duration studies reporting clinically useful levels of pain relief for individual participants provided no convincing evidence that lamotrigine is effective in treating neuropathic pain and fibromyalgia at doses of about 200 to 400 mg daily. Given the availability of more effective treatments including antiepileptics and antidepressant medicines, lamotrigine does not have a significant place in therapy based on the available evidence. The adverse effect profile of lamotrigine is also of concern. PMID: 24297457 [PubMed - as supplied by publisher]
Source: Cochrane Database of Systematic Reviews - December 3, 2013 Category: Journals (General) Authors: Wiffen PJ, Derry S, Moore RA Tags: Cochrane Database Syst Rev Source Type: research