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Evidence to Support the Use of S-Adenosylmethionine for Treatment of Post-Concussive Sequelae in the Military
CONCLUSION: There is evidence of a potential benefit of SAMe as an intervention to help with symptoms across the range of post-concussive sequelae and syndromes commonly seen in military mTBI. Since the discovery of SAMe in 1952, this pleiotropic molecule has shown the significance of its involvement in several metabolic cascades in such disparate systems as epigenetics, bioenergetics, DNA methylation, neurotransmitter systems, and potential usefulness in military TBI. Significant limitations include disparate presentations seen in patients with mild TBI, those with post-concussive syndrome, as well as those with comorbid ...
Source: Military Medicine - April 26, 2021 Category: International Medicine & Public Health Authors: Danny A Schieffler Sofia E Matta Source Type: research