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Clinical factors linked with coronary artery disease in chronic obstructive pulmonary disease (COPD)
Conclusion: Our data showed that hypertension, left heart failure, and lower serum HDL level were independent predictors for the presence of CAD in COPD. FEV1 and triple vessel CAD were independently associated with the survival of the patients with COPD.
Source: European Respiratory Journal - December 23, 2014 Category: Respiratory Medicine Authors: Park, J. H., Ahn, Y. H., Ki, S. K., Jung, Y. J., Lee, K. S., Jung, W. Y., Sheen, S. S., Park, K. J. Tags: 5.2 Monitoring Airway Disease Source Type: research

Recruitment maneuvers in the presence of pulmonary hypertension: Cardiorespiratory effects during experimental acute lung injury
Conclusion- RM did not affect cardiac work and output regardless of conditions. Moreover in concomitant ALI, PHT somehow counteracted the deleterious effects of RM on elastance and SvO2.
Source: European Respiratory Journal - December 23, 2014 Category: Respiratory Medicine Authors: Doras, C., Le Guen, M., Petak, F., Habre, W. Tags: 4.1 Clinical Respiratory Physiology, Exercise and Functional Imaging Source Type: research

Association between coronary artery disease (CAD) and heart failure and age in obstructive sleep apnoea (OSA) patients
Conclusions: Coronary artery disease was frequent in OSA pts (more than 20%). We found strongest association between heart failure and age and CAD in OSA patients.
Source: European Respiratory Journal - December 23, 2014 Category: Respiratory Medicine Authors: Plywaczewski, R., Czyzak-Gradkowska, A., Targowska, M., Bielen, P., Sliwinski, P. Tags: 4.2 Sleep and Control of Breathing Source Type: research

Mortality in sarcoidosis, results from one centre, long term observational study
Conclusion:The leading cause of death in sarcoid patients in our Department were cancers, but just as often, sarcoidosis was the underlying cause of death.
Source: European Respiratory Journal - December 23, 2014 Category: Respiratory Medicine Authors: Puscinska, E., Nowinski, A., Goljan-Geremek, A., Bednarek, M., Kaminski, D., Kowalska, A., Gorecka, D. Tags: 1.5 Diffuse Parenchymal Lung Disease Source Type: research

Afterload reduction governs improvement in RV systolic function and ventriculo-arterial adaptation in patients with pulmonary arterial hypertension (PAH) undergoing rapid dose escalation of treprostinil
Conclusions: Treprostinil primarily exerts its effects by lowering RV afterload (Ea). This effect governs the improvement in RV systolic pump failure and contractile reserve. RV stiffness is related to afterload but unaffected by treprostinil. Thus, small improvements in RVEDV are likely related to a decrease in high baseline preload dependent (heterometric) autoregulation.
Source: European Respiratory Journal - December 23, 2014 Category: Respiratory Medicine Authors: Rischard, F., Vanderpool, R., Champion, H., Simon, M., Rischard, M., Jenkins, I., Knoper, S., Hansen, L., Waxman, A. Tags: 4.3 Pulmonary Circulation and Pulmonary Vascular Disease Source Type: research

Cardiac MRI derived right ventriculo-arterial coupling in pulmonary hypertension as a predictor of survival
Conclusion: SV/ESV predicts survival in PH, but does not seem to provide added value over ejection fraction (RVEF) and does not change with specific treatment. Correlation with invasive data is needed to assess if SV/ESV is an accurate reflection of VA coupling.Table1: Age and gender adjusted survival predictors. Abbreviations RVEDVI right ventricular (RV) end diastolic volume index; RVESVI RV end systolic volume index; LVEDVI left ventricular end diastolic volume indexTable2: baseline and follow up CMR variables after minimum of 3 months of therapy (mean ±SD or median (IQR)).
Source: European Respiratory Journal - December 23, 2014 Category: Respiratory Medicine Authors: Brewis, M., Naeije, R., Bellofiore, A., Chesler, N., Peacock, A. Tags: 4.3 Pulmonary Circulation and Pulmonary Vascular Disease Source Type: research

Metabolic diseases in parents and grandparents predict asthma and hay fever in offspring
Conclusion: This is the first study to show that familial cardio-metabolic disease predicts specific asthma phenotypes and hay fever, independent of familial asthma, suggesting that two distinct pathways carry asthma risk across generations, via familial asthma as well as cardio-metabolic disease.
Source: European Respiratory Journal - December 23, 2014 Category: Respiratory Medicine Authors: Carsin, A.-E., Svanes, C., Sunyer, J., Dratva, J., Norback, D., Holm, M., Lindberg, E., Benediktsdottir, B., Forsberg, B., Jogi, R., Schlunssen, V., Franklin, K., Gislason, T., Sigsgaard, T., Heinrich, J., Janson, C., Dharmage, S., Johannessen, A., Gomez Tags: 10.1 Respiratory Infections Source Type: research

Hemodynamic effects of different vasodilators in patients with type II pulmonary hypertension (PH)
Conclusions. Inhaled Iloprost causes favorable changes in preload and afterload of the impaired LV and increases its performance in patients with PH associated with LV systolic dysfunction.
Source: European Respiratory Journal - December 23, 2014 Category: Respiratory Medicine Authors: Bautin, A., Tashkhanov, D., Datsenko, S., Fedotov, P., Iakovlev, A., Moiseeva, O., Sitnikova, M. Tags: 4.3 Pulmonary Circulation and Pulmonary Vascular Disease Source Type: research

Right ventricular contractile reserve is markedly impaired and correlates with exercise capacity in pulmonary arterial hypertension: A dobutamine stress echocardiography study
Conclusions: RV contractile reserve can be assessed using DSE and may reveal subclinical RV dysfunction not apparent at rest. A correlation with exercise capacity suggests potential clinical value beyond resting measurements.
Source: European Respiratory Journal - December 23, 2014 Category: Respiratory Medicine Authors: Lau, E., Munoz, P., Sharma, T., Choudhary, P., Celermajer, D. Tags: 4.3 Pulmonary Circulation and Pulmonary Vascular Disease Source Type: research

Use of a USA population survey to describe tobacco exposure, respiratory symptoms, and chronic diseases among smokers
Conclusion: Our population-based data shows a significant relationship between prolonged tobacco use and frequency of respiratory symptoms as well as some chronic diseases.
Source: European Respiratory Journal - December 23, 2014 Category: Respiratory Medicine Authors: Liu, Y., Pleasants, R., Croft, J., Wheaton, A., Heidari, K., Ohar, J., Kraft, M., Mannino, D., Strange, C. Tags: 6.1 Epidemiology Source Type: research

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