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Echocardiography for defining the right ventricular contractile reserve in healthy subjects
Conclusions: These results provide age- and sex-related limits of normal RV contractile reserve as assessed by stress echocardiographic PASP, TAPSE, S and TAPSE/PASP. Right ventricular contractile reserve, however measured, correlates with exercise capacity.
Source: European Respiratory Journal - November 7, 2016 Category: Respiratory Medicine Authors: D'Alto, M., Pavelescu, A., Romeo, E., Argiento, P., Di Marco, G. M., Correra, A., Mattera Iacono, A., Russo, M. G., Naeije, R. Tags: 4.3 Pulmonary Circulation and Pulmonary Vascular Diseases Source Type: research

MRI derived left atrial volume index predicts treatment response in patients with PAH
Conclusion: This study shows that in patients meeting the haemodynamic criteria for PAH, patients with an elevated LA volume had poor response to PAH therapy. Further work to better characterize this PAH phenotype and recognize the importance of comorbidities in predicting response to therapy is required.
Source: European Respiratory Journal - November 7, 2016 Category: Respiratory Medicine Authors: Tubman, E., Sproson, T., Capener, D., Condliffe, R., Elliot, C., Charalampopolous, A., Kiely, D., Jim, W., Swift, A. Tags: 4.3 Pulmonary Circulation and Pulmonary Vascular Diseases Source Type: research

Prevalence of obstructive sleep apnea syndrome (OSAS) in men varies markedly according to definition criteria
Conclusion: Inclusion of co-morbidities in the ICSD-3 criteria does not notably increase OSAS prevalence over that determined by OSA symptoms alone. Better identification of who is at long-term risk from OSA-related complications is needed to define significant OSA.1 Heinzer R, et al. Lancet Resp Med. 2016; 4: e5-e6.
Source: European Respiratory Journal - November 7, 2016 Category: Respiratory Medicine Authors: Adams, R., Appleton, S., Vakulin, A., McEvoy, D., Antic, N., Catcheside, P., Taylor, A., Wittert, G. Tags: 4.2 Sleep and Control of Breathing Source Type: research

Response to treatment assessment in patients with PAH by MRI based computational modelling
Conclusion: The non-invasive proposed metrics have the potential to assess the response to PAH therapy, reducing the RHC interventions at follow-up.
Source: European Respiratory Journal - November 7, 2016 Category: Respiratory Medicine Authors: Lungu, A., Hose, R., Capener, D., Kiely, D., Wild, J., Swift, A. Tags: 4.3 Pulmonary Circulation and Pulmonary Vascular Diseases Source Type: research

Age is independently associated with pulmonary arterial compliance in health and in patients with pulmonary vascular disease
Discussion: Advancing age is independently associated with pulmonary arterial compliance in health and disease. In contrast to younger patients, pulmonary arterial compliance does not increase in response to PAH therapy in older patients.
Source: European Respiratory Journal - November 7, 2016 Category: Respiratory Medicine Authors: Swift, A., Lungu, A., Capener, D., Hammerton, C., Rothman, A., Lawrie, A., Elliot, C., Condliffe, R., Kiely, D., Wild, J. Tags: 4.3 Pulmonary Circulation and Pulmonary Vascular Diseases Source Type: research

Pulmonary arteriovenous malformations- Evidence of under recognition in respiratory medicine?
Conclusions: Publication patterns suggest continued under recognition of pulmonary PAVMs in mainstream respiratory medicine, favouring specific inclusion of this relatively common pulmonary vascular condition within Respiratory Medicine curricula.
Source: European Respiratory Journal - November 7, 2016 Category: Respiratory Medicine Authors: Shovlin, C., Gossage, J. Tags: 4.3 Pulmonary Circulation and Pulmonary Vascular Diseases Source Type: research

Change in right atrial minimal volume is a prognostic marker in pulmonary arterial hypertension (PAH)
Conclusion Change in minimal right atrial volume predicts mortality and maybe of value in the serial evaluation of patients on PAH therapy.
Source: European Respiratory Journal - November 7, 2016 Category: Respiratory Medicine Authors: Tubman, E., Sproson, T., Capener, D., Condliffe, R., Elliot, C., Charalampopolous, A., Kiely, D., Wild, J., Swift, A. Tags: 1.3 Imaging Source Type: research

Contrasting cardiovascular responses to exercise in mitochondrial myopathy and pulmonary arterial hypertension
Conclusion: A greater response of heart rate to oxygen consumption (HR/VO2≥120 beats/L) and the presence of an abnormal plateau of O2pulse during exercise are more frequently found in patients with PAH than MM.
Source: European Respiratory Journal - November 7, 2016 Category: Respiratory Medicine Authors: Degani-Costa, L. H., Rodrigues, M. T., Ramos, R. P., Ferreira, E. V. M., Fonseca, A. X. C., Gimenes, A., Bravo, D., Ota-Arakaki, J. S., Neder, J. A., Nery, L. E. Tags: 4.1 Clinical Physiology, Exercise and Functional Imaging Source Type: research

Risk of cardiovascular comorbidities in patients with idiopathic pulmonary fibrosis: Analysis of Medicare data
Conclusions: Newly diagnosed IPF pts are typically sicker than non-IPF pts and have significantly higher rates of CV conditions. The higher rate of CV conditions needs to be taken into consideration for the management and treatment of pts with IPF.
Source: European Respiratory Journal - November 7, 2016 Category: Respiratory Medicine Authors: Broder, M., Change, E., Papoyan, E., Popescu, I., Reddy, S., Raimundo, K., Chou, W., Stauffer, J. Tags: 6.1 Epidemiology Source Type: research

Clinical Impact of Gensini score in chronic obstructive pulmonary disease (COPD)
Conclusion: Our data suggest that high Gensini score in COPD was independently associated with cardiac co-morbidities such as triple vessel CAD and myocardial infarction.
Source: European Respiratory Journal - November 7, 2016 Category: Respiratory Medicine Authors: Park, J. H., Lee, K. S., Chung, W. Y., Sheen, S., Lee, J. Y., Lim, H.-S., Shin, J.-H., Tahk, S.-J. Tags: 5.2 Monitoring Airway Disease Source Type: research

Management of hypertension in obstructive sleep apnoea: predicting blood pressure reduction under continuous positive airway pressure
Hypertension affects a quarter of the adult population and remains a leading cause of cardiovascular mortality, accounting for 13.5% of all deaths. Half of all strokes and ischaemic heart disease events are attributable to high blood pressure (BP) [1, 2]. Most patients exhibit Grade-I hypertension (systolic BP of 140 to 159 mmHg and/or diastolic BP of 90 to 99 mmHg) without co-existing cardiovascular disease. An active reduction of BP results in a significant reduction in stroke and death [3].
Source: European Respiratory Journal - October 5, 2017 Category: Respiratory Medicine Authors: Tamisier, R., Levy, P. Tags: Sleep medicine Editorial Source Type: research

Association of inflammatory biomarkers with comorbidity in chronic obstructive pulmonary disease - results from the COSYCONET cohort
Conclusion: WBC correlates with disease severity and is associated with relevant comorbidities. Other classical inflammatory biomarkers did not show a clear correlation with COPD severity of existing comorbidity.
Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: Seiler, F., Trudzinski, F. C., Alquadrah, M., Fähndrich, S., Watz, H., Jörres, R. A., Koch, A., Welte, T., Vogelmeier, C. F., Biertz, F., Bals, R. Tags: Monitoring Airway Disease Source Type: research

The presence and impact of chronic kidney disease in COPD patients, data from the German COSYCONET cohort
Conclusion: COPD patients with CKD should receive special attention to detect other comorbidities.
Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: Alqudrah, M., Trudzinski, F., Seiler, F., Biertz, F., Koch, A., Vogelmeier, C., Welte, T., Watz, H., Fähndrich, S., Bals, R., Rudolf, J. Tags: Clinical Problems COPD Source Type: research

Cardiovascular comorbidity in Danish patients with scleroderma-associated interstitial lung disease
Conclusion: CC was frequent among patients with SSc-ILD but was not associated with increased mortality. As expected, PH was associated with severe excess mortality.
Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: Madsen, G. A., Hyldgaard, C., Bendstrup, E. Tags: Diffuse Parenchymal Lung Disease Source Type: research

The prevalence of Chronic Obstructive Pulmonary Disease (COPD) in Sri Lanka:outcome of the BOLD study
Conclusion: The prevalence of COPD in Sri Lankan adults is similar to global and regional prevalences.
Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: Amarasiri, L., Gunasinghe, W., Sadikeen, A., Fernando, A., Madegedara, D., Wickramasinghe, R., Gunasekera, K. Tags: Epidemiology Source Type: research

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