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Source: Journal of the Neurological Sciences
Condition: Hypertension
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Total 43 results found since Jan 2013.
Clinico-radiological predictors of vascular cognitive impairment (VCI) in patients with stroke: A prospective observational study
Conclusion: Post-stroke cognitive impairment is frequent and is associated with poor functional outcome. Predictors like lower educational status, strategic site lesion, greater severity of age related white matter changes and baseline stroke severity independently contributed to the risk of developing VCI in stroke patients.Highlights:
Source: Journal of the Neurological Sciences - March 31, 2014 Category: Neurology Authors: Tejendra Sukdeo Chaudhari, Rajesh Verma, Ravindra Kumar Garg, Manish Kumar Singh, Hardeep Singh Malhotra, Praveen kumar Sharma Tags: Original Articles Source Type: research
Stroke-prone renovascular hypertensive rat as an animal model for stroke studies: From artery to brain
Abstract: High blood pressure is a main risk factor for both initial and recurrent stroke. Compared to the poststroke situation in normotension, the brain lesion is larger in hypertension, and the treatments may not be as effective. Thus, the results from healthy individuals may not be directly applied to the hypertensive. In fact, the high prevalence of hypertension in stroke patients and its devastating effect urge the necessity to integrate arterial hypertension in the study of stroke in order to better mimic the clinical situations. The first step to do so is to have an appropriate hypertensive animal model for stroke ...
Source: Journal of the Neurological Sciences - August 19, 2013 Category: Neurology Authors: Song-Jie Liao, Ru-Xun Huang, Zhen-Pei Su, Jin-Sheng Zeng, Jian-Wei Mo, Zhong Pei, Ling Li, Yan-Nan Fang, Hua Hong, Hai-Wei Huang Tags: Review Source Type: research
Association of ALOX5AP1 SG13S114T/A variant with ischemic stroke, stroke subtypes and aspirin resistance
Abstract: The important role of genetic variants in the etiology and pathophysiology of stroke is being increasingly recognized. Simultaneously, the influence of genetic factors in the clinical outcome of drug therapy cannot be ignored. 5-lipoxygenase activating (ALOX5AP) gene involved in the synthesis of leukotrienes, has been recognized as an important gene contributing towards susceptibility of stroke risk. Leukotrienes are involved in the physiological mechanism of atherosclerotic events and inflammation. The present study was designed to identify the association of SG13S114T/A polymorphism in ALOX5AP1 gene with risk o...
Source: Journal of the Neurological Sciences - June 10, 2013 Category: Neurology Authors: Vandana Sharma, Sneha Dadheech, Subhash Kaul, A. Jyothy, Anjana Munshi Tags: Original Articles Source Type: research
Risk factors for stroke among patients with hypertension: A case–control study
Abstract: Background: In some African countries, more than half of the adult population are estimated to be hypertensive leading to an escalated burden of stroke in the continent. We conducted the first study to unravel the major risk factors for stroke among hypertensive patients (Nigerian-Africans) using a case–control design while also exploring the relative contributions of carotid intima medial thickness (CIMT) and carotid diameter as risk markers for stroke.Methods: Using conventional techniques, stroke-related demographic, clinical and laboratory data were obtained from 135 consecutive volunteering hypertensive st...
Source: Journal of the Neurological Sciences - December 20, 2012 Category: Neurology Authors: M.O. Owolabi, A.M. Agunloye Tags: Original Articles Source Type: research
Stroke warning syndrome: 18 new cases
Conclusion: SWS is an under-recognized syndrome. Intravenous rt-PA treatment seems to have lower efficacy than in other subtypes of strokes, but none of the patients with SWS undergoing treatment presented haemorrhagic transformation or other complications.
Source: Journal of the Neurological Sciences - June 13, 2013 Category: Neurology Authors: Rossana Tassi, Alfonso Cerase, Maurizio Acampa, Paolo D’Andrea, Francesca Guideri, Giuseppe Lo Giudice, Giovanna Marotta, Sandra Bracco, Giuseppe Martini Tags: Short Communictions Source Type: research
Estimated glomerular filtration rate and incident stroke in patients with hypertension and/or diabetes
Sarfo et al. conducted a prospective study to evaluate the effect of estimated glomerular filtration rate (eGFR) on incident stroke in patients with hypertension and/or type 2 diabetes mellitus [1]. The authors had reported the risk factors of incident stroke in patients with hypertension and/or type 2 diabetes mellitus by using the same database [2]. They recognized 54 events of stroke and stroke incidence rates increased with decreasing eGFR. Adjusted hazard ratios (HRs) (95% confidence intervals [CIs]) of eGFR with 60 –89 ml/min, 30–59 ml/min, and89 ml/min for incident stroke were 1.42 (0.63–3.21), 1.88 (1....
Source: Journal of the Neurological Sciences - December 27, 2018 Category: Neurology Authors: Tomoyuki Kawada Tags: Letter to the Editor Source Type: research
Management of blood pressure in acute stroke: Comparison of current prescribing patterns with AHA/ASA guidelines in a Sub-Saharan African referral hospital
High blood pressure (HBP) is common at acute phase of stroke. It may reflect untreated or uncontrolled hypertension before stroke, or it may relate to stress response. The present study was designed to compare current American Stroke Association (ASA) guidelines with actual prescribing patterns for management of HBP at the acute phase of stroke, in a tertiary care Hospital in Douala, Cameroon.
Source: Journal of the Neurological Sciences - October 5, 2017 Category: Neurology Authors: C. Kuate-Tegueu, J.J. Dongmo-Tajeuna, J. Doumbe, Y. Mapoure-Njankouo, G. Noubissi, V.D.P. Djientcheu Source Type: research
Patients with hypertension and/or diabetes and incident stroke: A risk assessment
Sarfo et al. conducted a prospective study to evaluate the risk of hypertension and diabetes for incident stroke [1]. The authors recognized 54 events of stroke, and incidence rates (95% confidence intervals [CIs]) of stroke per 1000 person-years in patients with diabetes and hypertension, only hypertension and only diabetes were 16.64 (10.58 –25.00), 13.77 (9.33–19.64) and 9.81 (3.59–21.74), respectively. In addition, adjusted hazard ratios (95% CI) of previous cigarette smoking and physical inactivity for incident stroke were 2.59 (1.18–5.67) and 1.81 (1.06–3.10).
Source: Journal of the Neurological Sciences - December 13, 2018 Category: Neurology Authors: Tomoyuki Kawada Tags: Letter to the Editor Source Type: research
CHADS2 score predicts functional outcome of stroke in patients with a history of coronary artery disease
Abstract: Background: The aim of this study was to evaluate the efficacy of the CHADS2 scoring system as a prognostic tool for stroke patients with a prior history of coronary artery disease (CAD).Methods: We enrolled 148 acute ischemic stroke patients (mean age, 74.2years; males, 77.0%) with a history of CAD. Pre-admission CHADS2 scores were calculated by assigning a single point for the presence of congestive heart failure, hypertension, age ≥75years, and diabetes; and assigning 2 points for a prior history of stroke or transient ischemic attack. Comparisons were made between patients with poor and good 3-month functio...
Source: Journal of the Neurological Sciences - May 28, 2013 Category: Neurology Authors: Takao Hoshino, Kentaro Ishizuka, Satoru Shimizu, Shinichiro Uchiyama Tags: Original Articles Source Type: research
Risk factors and acute ischemic stroke subtypes
Conclusion: Specific AIS etiology and blood characteristics associated independently to the youngest and oldest AIS patients, respectively. Chronic kidney disease was a specific predictor of cerebellum–brainstem AIS. AIS mortality showed peculiar association with the oldest patients.
Source: Journal of the Neurological Sciences - January 31, 2014 Category: Neurology Authors: Aliaksei Kisialiou, Rodolfo Grella, Albino Carrizzo, Giordana Pelone, Michelangelo Bartolo, Chiara Zucchella, Francesco Rozza, Giovanni Grillea, Claudio Colonnese, Luigi Formisano, Maria Lembo, Annibale A. Puca, Carmine Vecchione Tags: Original Articles Source Type: research
Comparative effects of low-dose versus standard-dose alteplase in ischemic patients with prior stroke and/or diabetes mellitus: The ENCHANTED trial
History of prior stroke (PS) and diabetes mellitus (DM) are considered relative contraindications to the use of intravenous alteplase in patients with acute ischemic stroke (AIS). We aimed to assess whether a history of PS and DM modified the comparative effects of low- versus standard-dose alteplase in patients who participated in the alteplase-dose arm of the Enhanced Control of Hypertension and Thrombolysis Stroke Study (ENCHANTED).
Source: Journal of the Neurological Sciences - January 11, 2018 Category: Neurology Authors: Guofang Chen, Xia Wang, Thompson G. Robinson, Richard I. Lindley, Shengkui Zhou, Lei Ping, Weiwei Liu, Leijing Liu, John Chalmers, Craig S. Anderson, for the ENCHANTED Investigators Source Type: research
The impacts of premorbid hypertension treatment on functional outcomes of ischemic stroke
This study aimed to evaluate the impacts of premorbid hypertension treatment on the functional outcomes in patients with acute ischemic stroke and hypertension.
Source: Journal of the Neurological Sciences - February 10, 2016 Category: Neurology Authors: Qinqin Cao, Shuyu Zhou, Biyang Cai, Qing Wang, Jun Zhang, Ruifeng Shi, Keting Liu, Xinfeng Liu, Gelin Xu Source Type: research
Administration of a pictorial questionnaire to screen for stroke among patients with hypertension or diabetes in rural Ghana
Stroke prevention is an important public health goal in low-and-middle income countries (LMIC) due to its high mortality and morbidity in these settings. Epidemiological data from high-income countries have demonstrated a potent predictive association between self-reported stroke symptoms and risks of future strokes, incident cognitive impairment and all-cause mortality.
Source: Journal of the Neurological Sciences - January 6, 2017 Category: Neurology Authors: Fred S. Sarfo, Rexford Adu Gyamfi, Sheila Adamu, Osei Sarfo-Kantanka, Mayowa Owolabi, Bruce Ovbiagele Source Type: research
Feasibility study of a targeted self-management intervention for reducing stroke risk factors in a high-risk population in Uganda
Stroke remains a global concern due to increasing lifespan, patterns of industrialization, adoption of harmful western diets, and an increasing prevalence of risk factors such as hypertension, obesity, and diabetes. We investigated an adopted novel self-management intervention, TargetEd mAnageMent Intervention (TEAM) to reduce modifiable stroke risk factors in Uganda.
Source: Journal of the Neurological Sciences - January 4, 2018 Category: Neurology Authors: Mark Kaddumukasa, Jane Nakibuuka, Levicatus Mugenyi, Olivia Namusoke, Bryan Kabaala, Carol Blixen, Elly Katabira, Anthony Furlan, Martha Sajatovic, Doreen Birungi Source Type: research
In a stroke cohort with incident hypertension; are more women than men likely to be excluded from recombinant tissue-type Plasminogen Activator (rtPA)?
The treatment outcomes in the use of rt-PA have been reported. Some studies reported worse outcome in women than men, while others presented opposing data. Using data from a hospital-based stroke registry, we investigated evidence of gender difference and determined exclusion criteria in a stroke population with incidence of hypertension.
Source: Journal of the Neurological Sciences - February 7, 2018 Category: Neurology Authors: Jordan Gainey, Leanne Brechtel, Sarah Konklin, Lee Madeline, Lowther Ervin, Brice Blum, Thomas I. Nathaniel Source Type: research
