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Source: Journal of Stroke and Cerebrovascular Diseases
Condition: Hypertension
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Total 220 results found since Jan 2013.
Metformin-inclusive Therapy Reduces the Risk of Stroke in Patients with Diabetes: A 4-Year Follow-up Study
Metformin is a kind of oral hypoglycemic agents commonly prescribed to patients with diabetes mellitus. Although past studies had proven its protective effect on cardiovascular risk and related mortality, the evidence of metformin on stroke prevention was still insufficient and conflicting. Our study randomly selected 14,856 patients with diabetes from the database provided by the Taiwan National Health Research Institute, and 2 cohorts were formulated according to whether metformin was in the prescription record. All cases were followed up for 4 years to track their stroke incidence. As a result, 701 (17.5%) of 3999 diabe...
Source: Journal of Stroke and Cerebrovascular Diseases - October 11, 2013 Category: Neurology Authors: Yuan-Yang Cheng, Hsin-Bang Leu, Tzeng-Ji Chen, Chen-Ling Chen, Chia-Hua Kuo, Shin-Da Lee, Chung-Lan Kao Tags: Original Articles Source Type: research
Metabolic Syndrome Associated with Ischemic Stroke among the Mexican Hispanic Population in the El Paso/US–Mexico Border Region
In this report, data were collected in the El Paso/US–Mexico border region, where 82% of the population is Mexican Hispanic, through a retrospective study of ischemic stroke from 2005-2010. Odds ratios (ORs), 95% confidence intervals, logistic regression, and multivariate analysis of the ORs adjusted for other variables, were used to analyze the effects of various risk factors on ischemic stroke. The metabolic syndrome and its components, specifically hypertension, diabetes, and dyslipidemia appeared to be strongly associated with ischemic stroke in the Mexican Hispanic population. Mexican Hispanic ischemic stroke patien...
Source: Journal of Stroke and Cerebrovascular Diseases - February 19, 2014 Category: Neurology Authors: Michael F. Osborn, Charles C. Miller, Ahmed Badr, Jun Zhang Tags: Original Articles Source Type: research
Safety and Effectiveness of Endovascular Treatment after 6 Hours of Symptom Onset in Patients with Anterior Circulation Ischemic Stroke: A Matched Case Control Study
Conclusions: We did not observe any evidence of benefit in halting neurologic worsening or improving outcomes among patients undergoing endovascular treatment for treatment of an anterior circulation ischemic stroke after 6 hours of symptom onset. Strong evidence of both the safety and efficacy of emergent endovascular treatment when administered to patients with stroke in the anterior circulation is needed.
Source: Journal of Stroke and Cerebrovascular Diseases - October 24, 2012 Category: Neurology Authors: Adnan I. Qureshi, Jefferson T. Miley, Saqib A. Chaudhry, Edouard Semaan, Gustavo J. Rodriguez, M.Fareed K. Suri, Harold P. Adams Tags: Original Articles Source Type: research
Studying Effects of Weather Parameters on Acute Stroke: Considering the Contribution of “Risk Factors” and “Triggering Factors” Together
A recently published article in the Journal of Stroke and Cerebrovascular Diseases regarding the effect of season and atmospheric temperature variation in acute stroke by Gomes et al has drawn our attention. The authors studied the variation in the incidence of stroke hospitalizations across seasons and with short-term temperature change in a tropical setting by examining 651 consecutive stroke events occurred during the period of August 1, 2005, through July 31, 2006. The study illustrated that sudden declines in the minimum temperature over the 5-10 days before the event were associated with a 20%-30% higher incidence...
Source: Journal of Stroke and Cerebrovascular Diseases - August 21, 2013 Category: Neurology Authors: Mohammad Al Mamun, Nahid Rumana, Adrian V. Specogna, Tanvir C. Turin Tags: Letters to the Editor Source Type: research
Brain Natriuretic Peptide in Acute Ischemic Stroke
Elevated serum brain natriuretic peptide (BNP) levels are associated with cardioembolic stroke mainly because of atrial fibrillation (AF). However, the mechanisms of increased serum BNP levels are hitherto unclear. We aimed to identify the factors associated with increased BNP levels in patients with acute ischemic stroke. We measured serum BNP levels in consecutive patients aged 18 years or older. Stroke subtypes were classified using the Trial of ORG 10172 in Acute Stroke Treatment criteria. Categorical variables included age, sex, smoking status, alcohol consumption status, hypertension, diabetes mellitus, dyslipidemia...
Source: Journal of Stroke and Cerebrovascular Diseases - October 10, 2013 Category: Neurology Authors: Kenji Maruyama, Tsuyoshi Shiga, Mutsumi Iijima, Saori Moriya, Satoko Mizuno, Sono Toi, Kotaro Arai, Kyomi Ashihara, Kayoko Abe, Shinichiro Uchiyama Tags: Original Articles Source Type: research
Quality of Life after Lacunar Stroke: The Secondary Prevention of Small Subcortical Strokes Study
Background: We sought to describe the course and predictors of quality of life (QOL) after lacunar stroke. We hypothesized that there is a decline in QOL after recovery from lacunar stroke.Methods: The Secondary Prevention of Small Subcortical Strokes is a clinical trial in lacunar stroke patients with annual assessments of QOL with the stroke-specific QOL score. The overall score was used and analyzed as a continuous variable (range 0-5). We fit linear mixed models to assess the trend in QOL over time, assuming linearity of time, and adjusted for demographics, medical risk factors, cognitive factors, and functional status...
Source: Journal of Stroke and Cerebrovascular Diseases - October 30, 2013 Category: Neurology Authors: Mandip S. Dhamoon, Leslie A. McClure, Carole L. White, Helena Lau, Oscar Benavente, Mitchell S.V. Elkind Tags: Original Articles Source Type: research
Occurrence and Predictors of Persistent Impaired Glucose Tolerance After Acute Ischemic Stroke or Transient Ischemic Attack
Conclusions: Half of the patients with impaired glucose tolerance after a TIA or ischemic stroke have persistent impaired glucose tolerance. We provide a prediction model to identify patients at risk of persistent impaired glucose tolerance, with statin use, triglyceride, and fasting plasma glucose as the most important predictors, which after external validation might be used to optimize secondary prevention.
Source: Journal of Stroke and Cerebrovascular Diseases - April 10, 2014 Category: Neurology Authors: Susanne Fonville, Heleen M. den Hertog, Adrienne A.M. Zandbergen, Peter J. Koudstaal, Hester F. Lingsma Tags: Original Articles Source Type: research
Association of Variants in KCNK17 Gene with Ischemic Stroke and Cerebral Hemorrhage in a Chinese Population
Conclusions: The T carrier of an SNP (rs12214600) is associated with reduced risk of cerebral hemorrhage in the Chinese population, together with previous findings that SNPs rs10947803 and rs12214600 in the KCNK17 gene are associated with hemorrhagic stroke, but none of the SNPs tested had an association with ischemic stroke. KCNK17 may be important in the pathogenesis of cerebral hemorrhage.
Source: Journal of Stroke and Cerebrovascular Diseases - September 1, 2014 Category: Neurology Authors: Lingbin He, Qingfeng Ma, Yongqin Wang, Xin Liu, Yuan Yuan, Yongzhi Zhang, Wenjing Ou, Lisheng Liu, Xuerui Tan, Xingyu Wang Tags: Original Articles Source Type: research
Risk factors and pathogenic microorganism characteristics for pneumonia in convalescent patients with stroke: A retrospective study of 380 patients from a rehabilitation hospital
Stroke significantly impacts public health and ranks among the leading causes of death and disabilities, resulting in enormous costs measured in both health care resources and lost productivity. It results primarily from embolus or thrombosis for ischemic stroke and hypertension for hemorrhagic stroke, respectively [1]. In 2016, there were 5.5 million deaths and 116.4 million disability-adjusted life-years (DALYs) owed to stroke [2]. As reported, the impact of stroke on the Chinese population is more severe compared to average global levels, and the prevalence of stroke continues to surpass that of ischemic heart disease [3 –4].
Source: Journal of Stroke and Cerebrovascular Diseases - May 13, 2020 Category: Neurology Authors: Jia Xu, Zhiling Yang Source Type: research
Chronic Kidney Disease and Risk of Stroke. Resolved Chronic Kidney Disease is A Biomarker Rather Than A Risk Factor for Stroke
Over the last approximate 15 years some have suggested that chronic kidney disease (CKD) is a risk factor for stroke in and of itself. The assertion that CKD is a risk factor for stroke requires more scrutiny. It is possible that CKD is a reflection of severity of conditions such as hypertension and diabetes that are themselves among the most treatable risk factors for stroke or it is possible that the effects of CKD change vascular and related physiological functions and therefor directly contribute to increased risk of stroke and it is also possible that treatments for advance CKD such has hemodialysis could contribute t...
Source: Journal of Stroke and Cerebrovascular Diseases - May 29, 2021 Category: Neurology Authors: Judy Dawod, Bruce M Coull Source Type: research
Association between Inflammatory Biomarkers and Progression of Intracranial Large Artery Stenosis after Ischemic Stroke
Conclusions: In addition to traditional risk factors and baseline radiologic findings, circulating levels of IL-6 measured soon after stroke onset are associated with future ILA progression.
Source: Journal of Stroke and Cerebrovascular Diseases - October 14, 2011 Category: Neurology Authors: Kanako Shimizu, Kana Shimomura, Yoshiaki Tokuyama, Kenzo Sakurai, Kenji Isahaya, Satoshi Takaishi, Bunta Kato, Noriko Usuki, Takahiro Shimizu, Koji Yamada, Yasuhiro Hasegawa Tags: Original Articles Source Type: research
Epidemiology, Pathophysiology, and Treatment of Hypertension in Ischaemic Stroke Patients
Stroke continues to be one of the leading causes of mortality and morbidity worldwide. There are 2 main types of stroke: ischaemic strokes, which are caused by obstruction of the blood vessels leading to or within the brain, and haemorrhagic strokes, which are induced by the disruption of blood vessels. Stroke is a disease of multifactorial aetiology that may develop as an end state in patients with serious vascular conditions—most notably, uncontrolled arterial hypertension—thereby necessitating the effective control of this risk factor to prevent stroke or its recurrence. This paper focuses specifically on the epidem...
Source: Journal of Stroke and Cerebrovascular Diseases - June 11, 2012 Category: Neurology Authors: Nur Fatirul Hisham, Ulvi Bayraktutan Tags: Review Articles Source Type: research
C-reactive Protein and Homocysteine Predict Long-term Mortality in Young Ischemic Stroke Patients
Conclusions: There is an independent association between CRP and homocysteine levels obtained several years after ischemic stroke in young adults and subsequent mortality, even when adjusting for traditional risk factors. This association seems to continue for at least 12 years after the measurements.
Source: Journal of Stroke and Cerebrovascular Diseases - June 3, 2013 Category: Neurology Authors: Halvor Naess, Harald Nyland, Titto Idicula, Ulrike Waje-Andreassen Tags: Original Articles Source Type: research
Critical Role of Matrix Metalloproteinase-9 in Acute Cold Exposure–Induced Stroke in Renovascular Hypertensive Rats
Our objectives are to investigate the role of MMP-9 in cold exposure–induced stroke and assess the preventive effect of doxycycline, a total of 200 rats were assigned to a control group, sham group, 2-kidney, 2-clip (2K–2C) group, and doxycycline-received 2K-2C group (2K–2C + doxy) (N = 50, each), and subsequently, each group were randomly assigned to 2 groups: acute cold exposure (ACE) and nonacute cold exposure (NACE) (N = 25, each). After the blood pressure was stabilized, rats were maintained on a 12-h light (22°C)/dark (4°C) cycle (ACE group) or a 12-h light (22°C)/dark (22°C) cycle (NACE group) for 3 cycl...
Source: Journal of Stroke and Cerebrovascular Diseases - June 24, 2013 Category: Neurology Authors: Chunguang Li, Xiangpen Li, Qingyu Shen, Yi Li, Lei He, Mei Li, Yamei Tang, Yidong Wang, Qingyu He, Ying Peng Tags: Original Articles Source Type: research
The Detrimental Effect of Aging on Leptomeningeal Collaterals in Ischemic Stroke
Conclusion: Our findings show that there is a significant interplay between patient age and adequacy of leptomeningeal collateral circulation in patients with proximal MCA occlusion. The relationship could contribute to adverse tissue outcome and thereby to unfavorable clinical outcome observed in elderly patients with ischemic stroke.
Source: Journal of Stroke and Cerebrovascular Diseases - April 12, 2013 Category: Neurology Authors: Ethem Murat Arsava, Atay Vural, Erhan Akpinar, Rahsan Gocmen, Seray Akcalar, Kader K. Oguz, Mehmet Akif Topcuoglu Tags: Original Articles Source Type: research
