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Predictors of Thrombolysis Administration in Mild Stroke Clinical Sciences
Conclusions—Mild acutely presenting stroke patients are more likely to receive thrombolysis if they are young, white, or Hispanic and arrive early to the hospital with more severe neurological presentation. Identification of predictors of thrombolysis is important in design of future studies to assess the use of thrombolysis for mild stroke.
Source: Stroke - February 26, 2018 Category: Neurology Authors: Negar Asdaghi, Kefeng Wang, Maria A. Ciliberti-Vargas, Carolina Marinovic Gutierrez, Sebastian Koch, Hannah Gardener, Chuanhui Dong, David Z. Rose, Enid J. Garcia, W. Scott Burgin, Juan Carlos Zevallos, Tatjana Rundek, Ralph L. Sacco, Jose G. Romano Tags: Cerebrovascular Disease/Stroke, Ischemic Stroke, Transient Ischemic Attack (TIA) Original Contributions Source Type: research

Recanalization Modulates Association Between Blood Pressure and Functional Outcome in Acute Ischemic Stroke Clinical Sciences
Conclusions— Systemic BP in the first 24 hours after ischemic stroke influences 3-month clinical outcome. This association is dependent on the revascularization status.
Source: Stroke - May 22, 2016 Category: Neurology Authors: Martins, A. I., Sargento-Freitas, J., Silva, F., Jesus-Ribeiro, J., Correia, I., Gomes, J. P., Aguiar-Goncalves, M., Cardoso, L., Machado, C., Rodrigues, B., Santo, G. C., Cunha, L. Tags: High Blood Pressure, Hypertension, Cerebrovascular Procedures, Ischemic Stroke Clinical Sciences Source Type: research

Clinical Utility of Electronic Alberta Stroke Program Early Computed Tomography Score Software in the ENCHANTED Trial Database Clinical Sciences
Background and Purpose—Clinical utility of electronic Alberta Stroke Program Early CT Score (e-ASPECTS), an automated system for quantifying signs of infarction, was evaluated in a large database of thrombolyzed patients with acute ischemic stroke.Methods—All baseline noncontrast computed tomographic scans of patients with anterior circulation acute ischemic stroke who participated in the alteplase dose arm of the randomized controlled trial ENCHANTED (Enhanced Control of Hypertension and Thrombolysis Stroke Study) were reviewed; poor quality and large (>6 mm) slice thickness were excluded. Included scans had e-ASPECTS...
Source: Stroke - May 25, 2018 Category: Neurology Authors: Simon Nagel, Xia Wang, Cheryl Carcel, Thompson Robinson, Richard I. Lindley, John Chalmers, Craig S. Anderson Tags: Cerebrovascular Disease/Stroke, Ischemic Stroke Original Contributions Source Type: research

Population-Based Case-Control Study of White Matter Changes on Brain Imaging in Transient Ischemic Attack and Ischemic Stroke Clinical Sciences
Conclusions— In contrast to small vessel ischemic events, WMC were not independently associated with other pathogenic subtypes, suggesting that WMC are unlikely to be an independent risk factor for nonsmall vessel events.
Source: Stroke - October 21, 2013 Category: Neurology Authors: Li, L., Simoni, M., Kuker, W., Schulz, U. G., Christie, S., Wilcock, G. K., Rothwell, P. M. Tags: Computerized tomography and Magnetic Resonance Imaging, Epidemiology Clinical Sciences Source Type: research

Difference in Aneurysm Characteristics Between Ruptured and Unruptured Aneurysms in Patients With Multiple Intracranial Aneurysms Clinical Sciences
Conclusions— Aspect ratio ≥1.3 and irregular shape are associated with aneurysm rupture independent of aneurysm size and location, and independent of patient characteristics. Additional studies need to assess to what extent these factors increase the risks of rupture of small aneurysms in absolute terms.
Source: Stroke - April 28, 2014 Category: Neurology Authors: Backes, D., Vergouwen, M. D. I., Velthuis, B. K., van der Schaaf, I. C., Bor, A. S. E., Algra, A., Rinkel, G. J. E. Tags: Cerebrovascular disease/stroke, Cerebral Aneurysm, AVM, & Subarachnoid hemorrhage, Computerized tomography and Magnetic Resonance Imaging Clinical Sciences Source Type: research

Autoregulation of Cerebral Blood Flow is Preserved in Primary Intracerebral Hemorrhage Brief Reports
Conclusions— CBF remained stable after acute BP reduction, suggesting some preservation of cerebral autoregulation.
Source: Stroke - May 24, 2013 Category: Neurology Authors: Gould, B., McCourt, R., Asdaghi, N., Dowlatshahi, D., Jeerakathil, T., Kate, M., Coutts, S. B., Hill, M. D., Demchuk, A. M., Shuaib, A., Emery, D., Butcher, K., on behalf of the ICH ADAPT investigators Tags: Acute Cerebral Hemorrhage, Brain Circulation and Metabolism Brief Reports Source Type: research

Morphological, Hemodynamic, and Clinical Independent Risk Factors for Anterior Communicating Artery Aneurysms Clinical Sciences
Conclusions— The risk of ACoA aneurysm formation is determined by several independent clinical, morphological, and hemodynamic factors. The strongest independent risk factors include smoking, asymmetry of A1 segments >40%, low blood flow pulsatility, and the angle between A1 and A2 segments ≤100°.
Source: Stroke - September 22, 2014 Category: Neurology Authors: Kaspera, W., Ładziłski, P., Larysz, P., Hebda, A., Ptaszkiewicz, K., Kopera, M., Larysz, D. Tags: Cerebral Aneurysm, AVM, & Subarachnoid hemorrhage, Aneurysm, AVM, hematoma Clinical Sciences Source Type: research

Effectiveness of Diagnostic Strategies in Suspected Delayed Cerebral Ischemia: A Decision Analysis Clinical Sciences
Conclusions— Imaging studies to test for the presence of angiographic vasospasm or perfusion deficits in patients with clinical DCI do not seem helpful in selecting which patients should undergo treatment and may not improve outcomes. Future directions include validating these results in prospective cohort studies.
Source: Stroke - December 22, 2014 Category: Neurology Authors: Rawal, S., Barnett, C., John-Baptiste, A., Thein, H.-H., Krings, T., Rinkel, G. J. E. Tags: Cerebral Aneurysm, AVM, & Subarachnoid hemorrhage, Angiography, Computerized tomography and Magnetic Resonance Imaging Clinical Sciences Source Type: research

Degree and Timing of Intensive Blood Pressure Lowering on Hematoma Growth in Intracerebral Hemorrhage: Intensive Blood Pressure Reduction in Acute Cerebral Hemorrhage Trial-2 Results Brief Reports
Conclusions— Intensive BP lowering with greater SBP reduction, which is achieved quickly and maintained consistently, seems to provide protection against hematoma growth for 24 hours. Clinical Trial Registration— URL: http://www.clinicaltrials.gov. Unique identifier: NCT00716079.
Source: Stroke - May 22, 2016 Category: Neurology Authors: Carcel, C., Wang, X., Sato, S., Stapf, C., Sandset, E. C., Delcourt, C., Arima, H., Robinson, T., Lavados, P., Chalmers, J., Anderson, C. S., on behalf of the INTERACT2 Investigators* Tags: High Blood Pressure, Intracranial Hemorrhage Brief Reports Source Type: research