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The Glomerulopathy of Sickle Cell Disease
Abstract Sickle cell disease (SCD) produces many structural and functional abnormalities in the kidney, including glomerular abnormalities. Albuminuria is the most common manifestation of glomerular damage, with a prevalence between 26% and 68% in adult patients. The pathophysiology of albuminuria in SCD is likely multifactorial, with contributions from hyperfiltration, glomerular hypertension, ischemia‐reperfusion injury, oxidative stress, decreased NO bioavailability and endothelial dysfunction. Although its natural history in SCD remains inadequately defined, albuminuria is associated with increased echocardiography�...
Source: American Journal of Hematology - May 1, 2014 Category: Hematology Authors: Kenneth I. Ataga, Vimal K. Derebail, David R. Archer Tags: Critical Review Source Type: research

Long‐Term Outcomes of Thrombotic Microangiopathy Treated with Plasma Exchange: A Systematic Review
Conclusions: Patients who survive an episode of TMA may be susceptible to long‐term vascular complications, but the magnitude of this risk and how to mitigate it remains unclear. This article is protected by copyright. All rights reserved.
Source: American Journal of Hematology - February 24, 2016 Category: Hematology Authors: Bashiar Thejeel, Amit X. Garg, William F. Clark, Aiden R. Liu, Arthur V. Iansavichus, Ainslie M. Hildebrand Tags: Critical Review Source Type: research