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Source: Journal of Stroke and Cerebrovascular Diseases
Condition: Hypertension
Drug: Doxycycline
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Total 1 results found since Jan 2013.
Critical Role of Matrix Metalloproteinase-9 in Acute Cold Exposure–Induced Stroke in Renovascular Hypertensive Rats
Our objectives are to investigate the role of MMP-9 in cold exposure–induced stroke and assess the preventive effect of doxycycline, a total of 200 rats were assigned to a control group, sham group, 2-kidney, 2-clip (2K–2C) group, and doxycycline-received 2K-2C group (2K–2C + doxy) (N = 50, each), and subsequently, each group were randomly assigned to 2 groups: acute cold exposure (ACE) and nonacute cold exposure (NACE) (N = 25, each). After the blood pressure was stabilized, rats were maintained on a 12-h light (22°C)/dark (4°C) cycle (ACE group) or a 12-h light (22°C)/dark (22°C) cycle (NACE group) for 3 cycl...
Source: Journal of Stroke and Cerebrovascular Diseases - June 24, 2013 Category: Neurology Authors: Chunguang Li, Xiangpen Li, Qingyu Shen, Yi Li, Lei He, Mei Li, Yamei Tang, Yidong Wang, Qingyu He, Ying Peng Tags: Original Articles Source Type: research
