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Can I use DOAC in a patient with renal disease?
Case A 76-year-old man is diagnosed with non-valvular atrial fibrillation. His comorbid conditions are hypertension, diabetes complicated by neuropathy, and chronic kidney disease stage 3. His current medications include metformin, lisinopril, gabapentin, and aspirin. His most recent laboratories showed a creatinine 1.8, creatinine clearance (CrCl) 35 mL/min, hemoglobin 11g/dL, and international normalized ratio 1.0. His congestive heart failure, hypertension, age, diabetes, stroke, vascular disease, and sex (CHADSVASc) score is 4. Which medication should we use to prevent stroke in this patient?  Brief overview of the is...
Source: The Hospitalist - February 3, 2022 Category: Hospital Management Authors: Ronda Whitaker Tags: Renal & Genitourinary Source Type: research

Restless Limbs Syndrome (RLS) Presenting as Hemisyndrome: A Case of Dejerine-Roussy Syndrome Responsive to Dopamine Agonists (P5.266)
CONCLUSION: Recognition of RLS as a hemisyndrome may offer new treatments for patients with chronic dysesthetic pain, paresthesia, and insomnia as illustrated in this case of DRS. RLS affects 10% of the population and DRS is seen in 10% after thalamic stroke. Pain associated with RLS may be contributing to chronic, persistent pain in patients with certain CNS lesions and may be treatable with Dopamine Agonists.Disclosure: Dr. Dickoff has received personal compensation for activities with UCB Pharma and Teva pharmaceuticals as a speaker.
Source: Neurology - April 9, 2014 Category: Neurology Authors: Dickoff, D. Tags: Movement Disorders: Sleep and Movement Disorders and Miscellaneous Diagnoses Source Type: research

Managing menopause.
Authors: Reid R, Abramson BL, Blake J, Desindes S, Dodin S, Johnston S, Rowe T, Sodhi N, Wilks P, Wolfman W, Menopause and Osteoporosis Working Group, Fortier M, Reid R, Abramson BL, Blake J, Desindes S, Dodin S, Graves L, Guthrie B, Khan A, Johnston S, Rowe T, Sodhi N, Wilks P, Wolfman W Abstract OBJECTIVE: To provide updated guidelines for health care providers on the management of menopause in asymptomatic healthy women as well as in women presenting with vasomotor or urogenital symptoms and on considerations related to cardiovascular disease, breast cancer, urogynaecology, and sexuality. OUTCOMES: Lifestyle...
Source: Journal of Obstetrics and Gynaecology Canada : JOGC - December 2, 2014 Category: OBGYN Tags: J Obstet Gynaecol Can Source Type: research

Antiepileptic drug use in Austrian nursing home residents
Abstract: Purpose: Currently around 30% of all newly developed seizures are diagnosed in persons older than 65 years. Five to 17% of nursing home-residents take antiepileptic drugs. The aim of our study was to analyze the type and frequency of prescribed antiepileptic drugs, as well as their indication, co-morbidities and co-medications in institutionalized elderly in Austria.Methods: This was a retrospective, cross-sectional study, which included all residents of the seven public nursing homes in Innsbruck, Austria. The data of 828 probands were extracted from the charts at site and maintained anonymously. The data collec...
Source: Seizure: European Journal of Epilepsy - November 12, 2012 Category: Neurology Authors: Doris Patricia Huber, Reinhard Griener, Eugen Trinka Tags: Regular Articles Source Type: research

Demographics, Comorbidities and Clinical Features in Hospitalized Patients with Myoclonus (P3.022)
CONCLUSIONS: Myoclonus was particularly associated with renal impairment in the presence of a toxic exposure, most commonly opioids or anticonvulsants, and unlike patients with anoxia or hepatic impairment, more often featured a negative semiology.Disclosure: Dr. Ehrlich has nothing to disclose. Dr. Swan has nothing to disclose. Dr. Robbins has received personal compensation for activities with MedLink and Prova Education. Dr. Robbins has received personal compensation in an editorial capacity for Current Pain and Headache Reports. Dr. Herskovitz has nothing to disclose. Dr. Milstein has nothing to disclose.
Source: Neurology - April 8, 2015 Category: Neurology Authors: Ehrlich, D., Swan, M., Robbins, M., Herskovitz, S., Milstein, M. Tags: Movement Disorders: Myoclonus, Paroxysmal Dyskinesias, and Parkinson ' s Disease Source Type: research

Nursing Home Residents with Seizure Disorders/Epilepsy: Prevalence, Characteristics, and Treatment Patterns (P1.080)
Conclusions: NHRs with seizure disorder/epilepsy have substantial physical and cognitive impairment. Nearly half were prescribed combination AED therapy, and >20[percnt] took 蠅3 different AEDs, suggesting refractory epilepsy. Additional research is needed to assess treatment outcomes and further define optimal care in this population.Disclosure: Dr. Zarowitz has nothing to disclose. Dr. Allen has nothing to disclose. Dr. OShea has nothing to disclose. Dr. Wang has nothing to disclose. Dr. Semenchuk has nothing to disclose. Dr. Barghout has nothing to disclose.
Source: Neurology - April 3, 2016 Category: Neurology Authors: Zarowitz, B., Allen, C., OShea, T., Wang, Z., Semenchuk, M., Barghout, V. Tags: Epilepsy/Clinical Neurophysiology: Geriatric Epilepsy, Epidemiology, and Health Services Source Type: research