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Activation of the NLRP3/IL-1 β/MMP-9 pathway and intracranial aneurysm rupture associated with the depletion of ERα and Sirt1 in oophorectomized rats
CONCLUSIONS: To the authors' knowledge, this work represents the first demonstration that, in an aneurysm model under estrogen-deficient conditions, the depletion of ERα and Sirt1 may contribute to activation of the NLRP3/IL-1β/MMP-9 pathway, facilitating the rupture of IAs in the estrogen-deficient rat IA rupture model.PMID:35594890 | DOI:10.3171/2022.4.JNS212945
Source: Journal of Neurosurgery - May 20, 2022 Category: Neurosurgery Authors: Tadashi Yamaguchi Takeshi Miyamoto Eiji Shikata Izumi Yamaguchi Kenji Shimada Kenji Yagi Yoshiteru Tada Masaaki Korai Keiko T Kitazato Yasuhisa Kanematsu Yasushi Takagi Source Type: research

Effect of Enteral Nutrition on In-hospital Infection and Hospital Expense in Stroke Patients: A Retrospective Assessment
Neurol Med Chir (Tokyo). 2021 Mar 9. doi: 10.2176/nmc.oa.2020-0350. Online ahead of print.ABSTRACTInfection is a common complication of stroke and is associated with unfavorable outcomes. Although nutritional intervention reduces the risk of postoperative infection, the impact of specific nutritional products remains unclear. From a hospital management perspective, we aimed to determine whether the provision of specific types of enteral nutrition in acute stroke patients affects infection control and hospital costs. In all, 45 acute hemorrhagic stroke patients receiving enteral nutrition in a single center (April 2017-Marc...
Source: Neurologia Medico-Chirurgica - March 11, 2021 Category: Neurosurgery Authors: Hidetaka Onodera Takuma Mogamiya Shinya Matsushima Taigen Sase Homare Nakamura Yohtaro Sakakibara Source Type: research