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Focusing on claudin-5: a promising candidate in the regulation of BBB to treat ischemic stroke
Publication date: Available online 5 December 2017 Source:Progress in Neurobiology Author(s): Jianjun Lv, Wei Hu, Zhi Yang, Tian Li, Shuai Jiang, Zhiqiang Ma, Fulin Chen, Yang Yang Claudin-5 is a tight junction (TJ) protein in the blood-brain barrier (BBB) that has recently attracted increased attention. Numerous studies have demonstrated that claudin-5 regulates the integrity and permeability of the BBB. Increased claudin-5 expression plays a neuroprotective role in neurological diseases, particularly in cerebral ischemic stroke. Moreover, claudin-5 might be a potential marker for early hemorrhagic transformation detecti...
Source: Progress in Neurobiology - December 6, 2017 Category: Neuroscience Source Type: research

The emerging role of signal transducer and activator of transcription 3 in cerebral ischemic and hemorrhagic stroke
Publication date: Available online 29 December 2015 Source:Progress in Neurobiology Author(s): Zhenxing Liang, Guiling Wu, Chongxi Fan, Jing Xu, Shuai Jiang, Xiaolong Yan, Shouyin Di, Zhiqiang Ma, Wei Hu, Yang Yang Signal transducers and activators of transcription (STATs) comprise a family of cytoplasmic transcription factors that mediate intracellular signaling. This signaling is typically generated at cell surface receptors, the activation of which results in the translocation of STATs to the nucleus. STATs are involved in biological events as diverse as embryonic development, programmed cell death, organoge...
Source: Progress in Neurobiology - January 13, 2016 Category: Neuroscience Source Type: research