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Exome sequencing identifies a novel intronic mutation in that causes recurrence of pulmonary arteriovenous malformations
We present here a Japanese family with a novel intronic heterozygous mutation of ENG, which was identified using whole exome sequencing (WES).
Source: Journal of the Neurological Sciences - April 1, 2015 Category: Neurology Authors: Naoki Saji, Toshitaka Kawarai, Ryosuke Miyamoto, Takahiro Sato, Hiroyuki Morino, Antonio Orlacchio, Ryosuke Oki, Kazumi Kimura, Ryuji Kaji Source Type: research

Fatal intracerebral haemorrhage following intravenous thrombolysis for acute ischaemic stroke: a hidden role for cerebral amyloid angiopathy?
Dear Editor,
Source: Journal of the Neurological Sciences - March 26, 2015 Category: Neurology Authors: Onte Ntlholang, Michael Farrell, Imelda Noone, Andreas Charidimou, Morgan Crowe Source Type: research

Isolated unilateral oculomotor paresis in pure midbrain stroke
and Purpose Pure midbrain stroke can cause isolated unilateral oculomotor paresis. We attempted to determine whether there is a difference in the oculomotor paresis pattern between pure midbrain infarction and midbrain hemorrhage.
Source: Journal of the Neurological Sciences - March 14, 2015 Category: Neurology Authors: Yu Amano, Yosuke Kudo, Hideyuki Kikyo, Ryoko Imazeki, Masahiro Yamamoto, Kazumitsu Amari, Fumiaki Tanaka, Ken Johkura Tags: Short communication Source Type: research

Spontaneous dissection of the bilateral internal carotid and vertebral arteries: A rationale for endovascular management
Spontaneous cervical-artery-dissection (sCAD) is a common cause of stroke in young patients. The incidence of concurrent sCAD of more than one neck artery ranges between 10 and 28% [1]. Multi-vessel sCAD is associated with a higher risk of intracranial hemorrhage as well as a higher risk of recurrent stroke or TIA [1]. Postpartum CAD accounts for 6% of spontaneous CAD in women under 50years of age [2]. Medical management is the primary treatment approach, while the role of endovascular intervention remains unclear.
Source: Journal of the Neurological Sciences - February 9, 2015 Category: Neurology Authors: Nitin Goyal, Shailesh Male, Vinodh T. Doss, Adam Arthur, Lucas Elijovich Tags: Letter to the Editor Source Type: research

Convexity Subarachnoid Hemorrhage in Ischemic Stroke
To report three cases of convexity subarachnoid hemorrhage (cSAH) after acute ischemic stroke and review the relevant literature.
Source: Journal of the Neurological Sciences - December 2, 2014 Category: Neurology Authors: N. Usmani, F.U. Ahmad, S. Koch Tags: Short communication Source Type: research

Corrigendum to a study of alpha-1 antichymotrypsin gene polymorphism in Indian stroke patients
Some typo-graphical errors have been noted in the abovementioned paper. The clinical information of primary spontaneous intracerebral hemorrhage (PSICH) was based on 193 patients but genetic study was only possible in 183 patients. This is because, in RFLP analysis, a clear and distinct band pattern was not possible in 10 patients due to poor PCR product quality. The corrected tables are as follows. (See Tables 2 and 3.)
Source: Journal of the Neurological Sciences - November 19, 2014 Category: Neurology Authors: Bindu I. Somarajan, J. Kalita, U.K. Misra, B. Mittal Source Type: research

Effects of tissue plasminogen activator timing on blood–brain barrier permeability and hemorrhagic transformation in rats with transient ischemic stroke
The goal of our study was to determine if the timing of the tissue plasminogen activator (tPA) administration influenced its effect on blood–brain barrier (BBB) permeability and the subsequent risk of hemorrhagic transformation.Thirty spontaneously hypertensive male rats were subjected to a 90-minute unilateral middle cerebral artery occlusion. Six rats did not receive tPA treatment (vehicle control: Group 0), intravenous tPA was administered immediately after reperfusion (Group 1) or 4h after reperfusion (Group 2).
Source: Journal of the Neurological Sciences - September 27, 2014 Category: Neurology Authors: Yanrong Zhang, Yi Wang, Zhiyi Zuo, Zhongxing Wang, Jack Roy, Qinghua Hou, Elizabeth Tong, Angelika Hoffmann, Emily Sperberg, Joerg Bredno, Stuart S. Berr, Mingxing Xie, Kevin Lee, Max Wintermark Source Type: research

Rivaroxaban presents a better pharmacokinetic profile than dabigatran in an obese non-diabetic stroke patient
Novel oral anticoagulants (NOACs) are the recent therapeutic breakthrough in the thromboprophylaxis of non-valvular atrial fibrillation (NVAF). There are currently three different molecules approved for NVAF: dabigatran, rivaroxaban and apixaban. All three agents have demonstrated at least non-inferiority at major clinical endpoints compared to warfarin with their major advantage being the fixed-dose regimen that necessitates no regular blood tests and protects patients from the disastrous effects of infra-therapeutic (embolism) or supra-therapeutic (hemorrhage) anticoagulation.
Source: Journal of the Neurological Sciences - September 14, 2014 Category: Neurology Authors: Apostolos Safouris, Anne Demulder, Nikos Triantafyllou, Georgios Tsivgoulis Tags: Letter to the Editor Source Type: research

Blood–retina-barrier disruption accompanying blood–brain-barrier dysfunction in posterior reversible encephalopathy syndrome
Blood-brain-barrier dysfunction is well known to accompany hypertensive posterior reversible encephalopathy syndrome (PRES) and is considered as the culprit of vasogenic edema and cerebral hemorrhage observed as part of this syndrome. An 84-year-old female was admitted with a diagnosis of PRES in the setting of malignant hypertension. The clinical course was further complicated by ischemic stroke and seizures. Contrast enhanced fluid attenuated inversion recovery (FLAIR) studies revealed diffuse enhancement within the subarachnoid space extending to regions without evidence of cytotoxic or vasogenic edema.
Source: Journal of the Neurological Sciences - August 29, 2014 Category: Neurology Authors: Esra Ozkan, Rahsan Gocmen, Mehmet Akif Topcuoglu, Ethem Murat Arsava Source Type: research

Repeated intravenous thrombolysis after recurrent stroke. A case series and review of the literature
Conclusions: IV re-thrombolysis may be safe and effective when recurrent stroke occurs after a period of complete neurologic regression lasting at least 24h or minor disability (mRS score ≤2) lasting at least 3months since the previous stroke.Highlights:
Source: Journal of the Neurological Sciences - July 25, 2014 Category: Neurology Authors: Manuel Cappellari, Giuseppe Moretto, Paolo Bovi Tags: Original Articles Source Type: research

Genetic variations of MMP9 gene and intracerebral hemorrhage outcome: A cohort study in Chinese Han population
Abstract: Objective: To investigate the association between genetic variations of matrix metalloproteinase 9 (MMP9) gene and intracerebral hemorrhage (ICH) outcome in Chinese Han population.Methods: The clinical data and peripheral blood samples from the patients with ICH were collected. The patients were followed up for 3months, and poor outcome was defined as death or dependency (modified Rankin scale score of 3–6). MassARRAY Analyser was used to genotype the tagger single nucleotide polymorphisms (SNPs) of MMP9 gene. Construction of haplotypes and genetic comparisons were performed by employing PLINK 1.0.7 software.Re...
Source: Journal of the Neurological Sciences - May 22, 2014 Category: Neurology Authors: Jie Yang, Sen Lin, Junshan Zhou, Bo Wu, Wei Dong, Hisatomi Arima, Hua Liu, Jing Zhang, Jie Li, Ming Liu, for the Chengdu Stroke Registry and Nanjing First Hospital Stroke Registry investigators Tags: Original Articles Source Type: research

Biomarkers of vasospasm development and outcome in aneurysmal subarachnoid hemorrhage
Abstract: Aneurysmal subarachnoid hemorrhage (SAH) is a neurologic emergency caused by a brain aneurysm burst, resulting in a bleeding into the subarachnoid space. Its incidence is estimated between 4 and 28/10,000 inhabitants and it is the main cause of sudden death from stroke. The prognosis of patients with SAH is directly related to neurological status on admission, to the magnitude of the initial bleeding, as well as to the development of cerebral vasospasm (CVS). Numerous researchers have studied the role of different biomarkers in CVS development. These biomarkers form part of the metabolic cascade that is triggered...
Source: Journal of the Neurological Sciences - May 8, 2014 Category: Neurology Authors: Ana Rodríguez-Rodríguez, Juan José Egea-Guerrero, Zaida Ruiz de Azúa-López, Francisco Murillo-Cabezas Tags: Original Articles Source Type: research

Genetic variations of MMP9 gene and intracerebral hemorrhage susceptibility: A case–control study in Chinese Han population
Conclusions: The genetic variations of MMP9 gene were not significantly associated with ICH susceptibility in the Chinese Han population.Highlights:
Source: Journal of the Neurological Sciences - April 28, 2014 Category: Neurology Authors: Jie Yang, Bo Wu, Sen Lin, Junshan Zhou, Yingbin Li, Wei Dong, Hisatomi Arima, Chanfei Zhang, Yukai Liu, Ming Liu, for the Chengdu stroke registry and Nanjing First Hospital stroke registry investigators Tags: Original Articles Source Type: research

Correlation between cerebral microbleeds and S100B/RAGE in acute lacunar stroke patients
Conclusions: Higher levels of S100B and lower levels of sRAGE are independently associated with presence and number of CMBs in patients with first-ever acute lacunar stroke, particularly in those with deep CMBs.Highlights:
Source: Journal of the Neurological Sciences - March 21, 2014 Category: Neurology Authors: Lulu Xiao, Wen Sun, Wenya Lan, Yunyun Xiong, Zuowei Duan, Zongjun Zhang, Wenping Fan, Lili Xu, Xia Xie, Nan Ma, Ruidong Ye, Gelin Xu, Xinfeng Liu, Wusheng Zhu Tags: Original Articles Source Type: research

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