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Outcomes of heart transplant recipients with prior left ventricular assist device associated stroke
Left ventricular assist devices (LVADs) improve survival in patients with end-stage heart failure but are associated with ischemic stroke and intracranial hemorrhage (ICH). The impact of LVAD-associated stroke on transplant candidacy and outcomes has not been characterized.
Source: Journal of Stroke and Cerebrovascular Diseases - June 7, 2023 Category: Neurology Authors: Aaron Shoskes, Merry Huang, Catherine Hassett, Randall C Starling, Eileen Hsich, Edward Soltesz, Sung-Min Cho, Ken Uchino Source Type: research

Rapidly Progressive Intracranial Vasculopathy in Graft Versus Host Disease
We report a previously undescribed noninflammatory vasculopathy causing multifocal intracranial arterial occlusions and cerebral infarctions in a man following allogenic hematopoietic stem cell transplantation for chronic lymphocytic leukemia, which we propose to be a central nervous system manifestation of graft versus host disease.
Source: Journal of Stroke and Cerebrovascular Diseases - March 12, 2019 Category: Neurology Authors: Theodore Bowen, Shawn A. Silver, Cathy Sila Tags: Case Report Source Type: research

Effects of GDNF-Transfected Marrow Stromal Cells on Rats with Intracerebral Hemorrhage
Objective: The present study aimed to investigate the effects of Mesenchymal stem cells/glial cell line derived neurotrophic factor (MSCs/GDNF) transplantation on nerve reconstruction in rats with intracerebral hemorrhage. Methods: GDNF transduction to MSCs was using adenovirus vector pAdEasy-1-pAdTrack-CMV prepared. Intracerebral hemorrhage (ICH) was induced by injection of collagenase and heparin into the caudate putamen. At the third day after a collagenase-induced ICH, adult male SD rats were randomly divided into saline group, MSCs group and MSCs/GDNF group.
Source: Journal of Stroke and Cerebrovascular Diseases - June 23, 2019 Category: Neurology Authors: Li Deng, Xiaoqing Gao, Guangbi Fan, Chaoxian Yang Source Type: research

Intracranial Hemorrhage Diagnosed with Transcranial Ultrasound in a Comatose, Postliver Transplant Patient
We report a case of an intracranial hemorrhage first suspected during a trans-cranial Doppler assessment of a postorthotopic liver transplant patient. The patient was at considerable risk of bleeding, due to a primary graft nonfunction, but he had also elevated ammonium levels, justifying the comatose state, and no focal neurological deficits.
Source: Journal of Stroke and Cerebrovascular Diseases - September 4, 2019 Category: Neurology Authors: Amedeo Bianchini, Rocco D'Andrea, Berin Lepic, Lorenzo Querci, Cristiana Laici, Antonio Siniscalchi Tags: Case Report Source Type: research

Management of Intracranial Hemorrhage in Patients with a Left Ventricular Assist Device: A Systematic Review and Meta-Analysis
Left Ventricular Assist Device (LVAD) therapy serves as a surgically implanted form of mechanical circulation in patients with advanced heart failure. Initially designed to provide a bridge to transplant, LVADs now offer an alternative that is increasingly utilized as final destination therapy as the need for donor hearts increases worldwide.1,2 However, this requires lifelong anticoagulation (AC) to prevent pump thrombosis, resulting in hemorrhagic risks.3
Source: Journal of Stroke and Cerebrovascular Diseases - December 1, 2020 Category: Neurology Authors: Austin H. Carroll, Michael P. Ramirez, Ehsan Dowlati, Kyle B. Mueller, Ali Borazjani, Jason J. Chang, Daniel R. Felbaum Tags: Review Article Source Type: research

Radiographic risk factors for intracranial hemorrhage in patients with left ventricular assist devices
Patients with end-stage cardiomyopathy may require the use of mechanical circulatory support to maintain perfusion of the vital organs. This is most commonly achieved using an implantable left ventricular assist device (LVAD), typically used as a bridge to orthotopic heart transplant (BTT) or as destination therapy (DT) for those who are not transplant candidates. An LVAD is usually considered for those patients whose disease and symptoms meet INTERMACS Levels 2-4 criteria, indicating a significant decrease in functionality.
Source: Journal of Stroke and Cerebrovascular Diseases - November 1, 2022 Category: Neurology Authors: Nicholas S. Hernandez, Matthew Kanter, Vaishnavi Sharma, Andy Wang, Michael Kiernan, Delia Kryzanski, Robert Heller, Tara Nail, Ron I. Riesenburger, James T. Kryzanski Source Type: research