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Cause-specific Mortality after Stroke: Relation to Age, Sex, Stroke Severity, and Risk Factors in a 10-Year Follow-up Study
We investigated cause-specific mortality in relation to age, sex, stroke severity, and cardiovascular risk factor profile in the Copenhagen Stroke Study cohort with 10 years of follow-up. In a Copenhagen community, all patients admitted to the hospital with stroke during 1992-1993 (n = 988) were registered on admission. Evaluation included stroke severity, computed tomography scan, and a cardiovascular risk profile. Cause of death within 10 years according to death certificate information was classified as stroke, heart/arterial disease, or nonvascular disease. Competing-risks analyses were performed by cause-specific Co...
Source: Journal of Stroke and Cerebrovascular Diseases - May 14, 2012 Category: Neurology Authors: Ulla Brasch Mogensen, Tom Skyhøj Olsen, Klaus Kaae Andersen, Thomas Alexander Gerds Tags: Original Articles Source Type: research

Wake-up Stroke Within 3 Hours of Symptom Awareness: Imaging and Clinical Features Compared to Standard Recombinant Tissue Plasminogen Activator Treated Stroke
Background: Patients with wake-up stroke (WUS) are excluded from thrombolysis because of unknown time of symptom onset. Previous studies have reported similar stroke severity and early ischemic changes (EICs) in patients with WUS and stroke of known onset. These studies, however, included patients within a large timeframe to imaging or did not quantify EICs. The aim of our study was to quantify EICs of patients with WUS presenting within 3 hours of symptom recognition compared to standard 3-hours recombinant tissue plasminogen activator (rt-PA)–treated patients and assess the extent of ischemic lesion and functional ind...
Source: Journal of Stroke and Cerebrovascular Diseases - December 1, 2011 Category: Neurology Authors: Luisa Roveri, Sara La Gioia, Chiara Ghidinelli, Nicoletta Anzalone, Costantino De Filippis, Giancarlo Comi Tags: Original Articles Source Type: research

Pooled Assessment of Computed Tomography Interpretation by Vascular Neurologists in the STRokE DOC Telestroke Network
Conclusions: Both vascular neurologists and reports from spoke radiologists had excellent reliability in identifying radiologic rt-PA contraindications. These pooled findings demonstrate that telestroke evaluation of head CT scans for acute rt-PA assessments is reliable.
Source: Journal of Stroke and Cerebrovascular Diseases - May 21, 2013 Category: Neurology Authors: Ilana Spokoyny, Rema Raman, Karin Ernstrom, Bart M. Demaerschalk, Patrick D. Lyden, Thomas M. Hemmen, Amy K. Guzik, James Y. Chen, Brett C. Meyer Tags: Original Articles Source Type: research

Safety of Intravenous Thrombolysis in Acute Ischemic Stroke Patients with Saccular Intracranial Aneurysms
Conclusions: Intravenous thrombolysis was safe among our patients with acute ischemic stroke and incidental intracranial saccular aneurysm.
Source: Journal of Stroke and Cerebrovascular Diseases - February 17, 2012 Category: Neurology Authors: Manoj K. Mittal, Raymond C.S. Seet, Yi Zhang, Robert D. Brown, Alejandro A. Rabinstein Tags: Original Articles Source Type: research

Telemedical Brain Computed Tomography Misinterpretation by Stroke Neurologists Is Not Associated with Thrombolysis-Related Intracranial Hemorrhage
The Stroke Eastern Saxony Network (SOS-NET) provides telecare for acute stroke patients. Stroke neurologists recommend intravenous thrombolysis based on clinical assessment and cerebral computed tomography (CT) evaluation using Alberta Stroke Program Early CT score (ASPECTS). We sought to assess whether ASPECTS misinterpretation by stroke neurologists was associated with thrombolysis-related symptomatic intracranial hemorrhage (sICH).
Source: Journal of Stroke and Cerebrovascular Diseases - April 11, 2015 Category: Neurology Authors: Charlotte Zerna, Ruediger von Kummer, Johannes Gerber, Kai Engellandt, Andrij Abramyuk, Claudia Wojciechowski, Kristian Barlinn, Jessica Kepplinger, Lars-Peder Pallesen, Timo Siepmann, Imanuel Dzialowski, Heinz Reichmann, Volker Puetz, Ulf Bodechtel Source Type: research

Cerebral Microbleeds on T2*-Weighted Images and Hemorrhagic Transformation after Antithrombotic Therapies for Ischemic Stroke
In conclusion, the severity of neurological deficits and the ASPECTS-DWI are closely correlated to the development of HT related to anticoagulants/antiplatelets but not to CMBs on T2*-weighted images.
Source: Journal of Stroke and Cerebrovascular Diseases - July 8, 2013 Category: Neurology Authors: Wakoh Takahashi, Yusuke Moriya, Atsushi Mizuma, Tsuyoshi Uesugi, Yoichi Ohnuki, Shunya Takizawa Tags: Original Articles Source Type: research

Early Magnetic Resonance Imaging Decreases Hospital Length of Stay in Patients with Ischemic Stroke
Imaging modalities are important part of stroke evaluation. Noncontrast head computed tomography (CT) is the initial imaging modality in acute stroke and although important to rule out acute hemorrhage and making a decision on thrombolytic treatment, ischemic changes may not be visible on CT for up to 24 hours. Magnetic resonance imaging (MRI) brain is an invaluable tool to confirm an ischemic stroke and facilitates stroke evaluation. Objective of this study was to investigate the correlation between time to MRI and length of hospital stay.
Source: Journal of Stroke and Cerebrovascular Diseases - November 3, 2018 Category: Neurology Authors: Bharti Manwani, Subhendu Rath, Nora S. Lee, Ilene Staff, Christoph Stretz, Janhavi Modak, Pasquale F. Finelli Source Type: research

Aortic Transgraft Hemorrhage after Intravenous Tissue Plasminogen Activator Therapy in Patients with Acute Ischemic Stroke
Conclusions: Our analysis provides reassurance regarding the risk of IV tPA therapy in patients undergoing aortic graft replacement.
Source: Journal of Stroke and Cerebrovascular Diseases - August 4, 2014 Category: Neurology Authors: Tomohiro Kawano, Katsufumi Kajimoto, Masahiro Higashi, Kenji Minatoya, Kazunori Toyoda, Kazuyuki Nagatsuka Tags: Original Articles Source Type: research

Time to ct scan imaging after symptom onset among ischeamic stroke patients presenting to a quaternary hospital in ghana
This study sought to determine the time of onset of symptoms to the time a CT imaging was done among patients presenting with acute stroke at the Korle-Bu Teaching Hospital.
Source: Journal of Stroke and Cerebrovascular Diseases - March 30, 2023 Category: Neurology Authors: F. Duodu, D. Brodie Mends, B. Agbinko-Djobalar, P. Pekyi-Boateng, M. Amerwornu, P Adjei, A Akpalu, K Nkromah Source Type: research

Investigating the Utility of Previously Developed Prediction Scores in Acute Ischemic Stroke Patients in the Stroke Belt
Conclusions: Our study demonstrated that although highly predictive of outcome in the original study design treatment groups, prediction scores may not generalize to all patient samples, highlighting the importance of validating prediction scores in diverse samples.
Source: Journal of Stroke and Cerebrovascular Diseases - August 11, 2014 Category: Neurology Authors: Amelia K. Boehme, Pawan V. Rawal, Michael J. Lyerly, Karen C. Albright, Reza Bavarsad Shahripour, Paola Palazzo, Niren Kapoor, Mohammad Alvi, J. Thomas Houston, Mark R. Harrigan, Luis Cava, April Sisson, Anne W. Alexandrov, Andrei V. Alexandrov Tags: Original Articles Source Type: research

The Value of Whole-Brain Perfusion Parameters Combined with Multiphase Computed Tomography Angiography in Predicting Hemorrhagic Transformation in Ischemic Stroke
Objective: To explore the value of whole-brain perfusion parameters combined with multiphase computed tomography angiography (MP-CTA) in predicting the hemorrhagic transformation (HT) of ischemic stroke. Methods: A total of 64 patients with ischemic stroke who underwent noncontrast computed tomography, computed tomography perfusion imaging, and computed tomography angiography before treatment from August 2017 to June 2019 were included retrospectively. The perfusion parameters cerebral blood volume (CBV), cerebral blood flow (CBF), time to peak (TTP), mean transit time (MTT), time to maximum (Tmax), and permeability surfac...
Source: Journal of Stroke and Cerebrovascular Diseases - February 13, 2020 Category: Neurology Authors: Xiang Li, Huan Liu, Wenbing Zeng, Xinghua Liu, Yun Wen, Qiuxia Xiong, Ran Yang Source Type: research

Demographic and Clinical Predictors of Leptomeningeal Collaterals in Stroke Patients
Background: Leptomeningeal collaterals improve outcome after stroke, including reduction of hemorrhagic complications after thrombolytic or endovascular therapy, smaller infarct size, and reduction in symptoms at follow-up evaluation. The purpose of this study was to determine the demographic and clinical variables that are associated with a greater degree of cerebral collaterals.Methods: Clinical data of patients presenting with M1 occlusions of the middle cerebral artery (MCA) and associated computed tomography angiography studies after admission from 3 separate institutions were retrospectively compiled (n = 82). Occl...
Source: Journal of Stroke and Cerebrovascular Diseases - August 4, 2014 Category: Neurology Authors: Nitin Malik, Qinghua Hou, Achala Vagal, James Patrie, Wenjun Xin, Patrik Michel, Ashraf Eskandari, Tudor Jovin, Max Wintermark Tags: Original Articles Source Type: research

Subacute Elevation of Plasma Level of Caspase-Cleaved Cytokeratin-18 is Associated with Hemorrhagic Transformation and Functional Outcome in Ischemic Stroke
Background: Caspase-cleaved cytokeratin-18 (CCCK-18) is an apoptosis marker. Here, we analyzed the relationship between plasma level of CCCK-18 in the acute and subacute stage of ischemic stroke and early and late functional outcome. Besides, correlation among CCCK-18 and complications, such as hemorrhagic transformation (HT) were also explored. Methods: Plasma concentration of CCCK-18 was investigated in 54 patients at admission and poststroke 72 hours. HT was evaluated by CT scans on 24 poststroke hours.
Source: Journal of Stroke and Cerebrovascular Diseases - December 5, 2018 Category: Neurology Authors: Tihamer Molnar, Kata Borocz, Timea Berki, Laszlo Szapary, Alex Szolics, Jozsef Janszky, Zsolt Illes, Peter Csecsei Source Type: research

Cardiac Arrhythmias and Acute Cerebrovascular Events: A Case of QT Prolongation and Torsades de Pointes Early After Right Insular Stroke
Stroke involving some areas of the cerebral hemisphere, such as insula, amygdala, and lateral hypothalamus, may cause changes in autonomic control of cardiac function. A 58-year-old woman presented to the emergency department for acute onset of left facial-brachial-crural hemiparesis and dysarthria. A brain CT scan showed subacute ischemic lesion with hemorrhagic infarction in right insular-rolandic cortex. Over the next few days ECG showed severe bradycardia with elongation of QTc, significative pauses (5 seconds), runs of nonsustained ventricular tachycardia and torsades de pointes.
Source: Journal of Stroke and Cerebrovascular Diseases - August 11, 2019 Category: Neurology Authors: Ilaria Jane Romano, Antonio Lippolis, Margherita D'Anna, Francesco Gentile Tags: Case Report Source Type: research

Contrast Extravasation is Predictive of Poor Clinical Outcomes in Patients Undergoing Endovascular Therapy for Acute Ischemic Stroke in the Anterior Circulation
To investigate whether contrast extravasation on dual-energy computed tomography (DECT) in patients with acute ischemic stroke (AIS) after endovascular therapy (EVT) are related to hemorrhagic transformation (HT) and poor short-term clinical outcomes.
Source: Journal of Stroke and Cerebrovascular Diseases - November 10, 2019 Category: Neurology Authors: Zhongyun Chen, Yingbo Zhang, Yingying Su, Yijia Sun, Yanbo He, Hongbo Chen Source Type: research

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