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Epidemiology, Pathophysiology, and Treatment of Hypertension in Ischaemic Stroke Patients
Stroke continues to be one of the leading causes of mortality and morbidity worldwide. There are 2 main types of stroke: ischaemic strokes, which are caused by obstruction of the blood vessels leading to or within the brain, and haemorrhagic strokes, which are induced by the disruption of blood vessels. Stroke is a disease of multifactorial aetiology that may develop as an end state in patients with serious vascular conditions—most notably, uncontrolled arterial hypertension—thereby necessitating the effective control of this risk factor to prevent stroke or its recurrence. This paper focuses specifically on the epidem...
Source: Journal of Stroke and Cerebrovascular Diseases - June 11, 2012 Category: Neurology Authors: Nur Fatirul Hisham, Ulvi Bayraktutan Tags: Review Articles Source Type: research

Influence of Experimental Subarachnoid Hemorrhage on Nicotine-induced Contraction of the Rat Basilar Artery in Relation to Nicotinic Acetylcholine Receptors, Calcium, and Potassium Channels
Conclusions: Nicotine-induced contraction of the rat basilar artery involved the CNS nAChR subfamily, skeletal muscle nAChR subfamily, and L-type Ca2+ channel pathways. SAH did not affect any of the subfamilies of nAChR, but the Ca2+ channel was reduced and the adenosine triphosphate–sensitive K+ channel was enhanced by SAH.
Source: Journal of Stroke and Cerebrovascular Diseases - November 4, 2011 Category: Neurology Authors: Xu Ji, Aimin Wang, Cristina C. Trandafir, Kazuyoshi Kurahashi Tags: Original Articles Source Type: research

Influence of Experimental Subarachnoid Hemorrhage on Nicotine-induced Contraction of the Rat Basilar Artery in Relation to Arachidonic Acid Metabolites Signaling Pathway
Conclusions: One week after exposure to SAH, PLC, sPLA2, and COX-2 activity were enhanced and cPLA2 activity was inhibited. One hour after exposure to SAH, PLC activity was enhanced and cPLA2 and iPLA2 activity was inhibited. Such changes of inflammatory arachidonic acid metabolites by smoking after SAH may play important roles in fatal cerebral circulatory disorders, suggesting important implications for the etiology and pathogenesis of SAH.
Source: Journal of Stroke and Cerebrovascular Diseases - January 3, 2012 Category: Neurology Authors: Xu Ji, Aimin Wang, Cristina C. Trandafir, Kazuyoshi Kurahashi Tags: Original Articles Source Type: research

Serum Calcium and Phosphate Levels and Short- and Long-Term Outcomes in Acute Intracerebral Hemorrhage Patients
We investigated whether admission serum calcium and phosphate levels are associated with short- and long-term outcomes in patients with acute intracerebral hemorrhage.
Source: Journal of Stroke and Cerebrovascular Diseases - January 29, 2016 Category: Neurology Authors: Shoujiang You, Qiao Han, Jiaping Xu, Chongke Zhong, Yu Zhang, Huihui Liu, Yanlin Zhang, Xinshun Xu, Chunfeng Liu, Yongjun Cao Source Type: research