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Source: Stroke
Condition: Hemorrhagic Stroke
Therapy: Gene Therapy
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Total 1 results found since Jan 2013.
Soluble FLT1 Gene Therapy Alleviates Brain Arteriovenous Malformation Severity Brief Report
Background and Purpose—Brain arteriovenous malformation (bAVM) is an important risk factor for intracranial hemorrhage. Current therapies are associated with high morbidities. Excessive vascular endothelial growth factor has been implicated in bAVM pathophysiology. Because soluble FLT1 binds to vascular endothelial growth factor with high affinity, we tested intravenous delivery of an adeno-associated viral vector serotype-9 expressing soluble FLT1 (AAV9-sFLT1) to alleviate the bAVM phenotype.Methods—Two mouse models were used. In model 1, bAVM was induced in R26CreER;Eng2f/2f mice through global Eng gene deletion and ...
Source: Stroke - April 24, 2017 Category: Neurology Authors: Wan Zhu, Fanxia Shen, Lei Mao, Lei Zhan, Shuai Kang, Zhengda Sun, Jeffrey Nelson, Rui Zhang, Dingquan Zou, Cameron M. McDougall, Michael T. Lawton, Thiennu H. Vu, Zhijian Wu, Abraham Scaria, Peter Colosi, John Forsayeth, Hua Su Tags: Angiogenesis, Animal Models of Human Disease, Gene Therapy Brief Reports Source Type: research
