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Clipping Versus Coiling for Ruptured Intracranial Aneurysms: A Systematic Review and Meta-Analysis Original Contributions
Conclusions— Coiling yields a better clinical outcome, the benefit being greater in those with a good preoperative grade than those with a poor preoperative grade. However, coiling leads to a greater risk of rebleeding. Well-designed randomized trials with special considerations to the aspect are needed.
Source: Stroke - December 24, 2012 Category: Neurology Authors: Li, H., Pan, R., Wang, H., Rong, X., Yin, Z., Milgrom, D. P., Shi, X., Tang, Y., Peng, Y. Tags: Cerebral Aneurysm, AVM, & Subarachnoid hemorrhage, Aneurysm, AVM, hematoma, Other Stroke Treatment - Surgical Original Contributions Source Type: research

Endovascular Treatment of Intracranial Aneurysms in Elderly Patients: A Systematic Review and Meta-Analysis Clinical Sciences
Conclusions— This study suggests that endovascular treatment of IAs in the elderly is associated with high long-term occlusion rates. Given the morbidity and mortality associated with endovascular treatment of IAs in the elderly, careful patient selection, especially in the case of patients with unruptured aneurysm, is recommended.
Source: Stroke - June 24, 2013 Category: Neurology Authors: Sturiale, C. L., Brinjikji, W., Murad, M. H., Lanzino, G. Tags: Cerebral Aneurysm, AVM, & Subarachnoid hemorrhage, Angiography Clinical Sciences Source Type: research

Variability in Outcome After Elective Cerebral Aneurysm Repair in High-Volume Academic Medical Centers Clinical Sciences
Conclusions— There is notable interhospital heterogeneity in outcomes among even the largest volume unruptured intracranial aneurysm referral centers. Although further regionalization may be needed, mandatory participation in prospective, adjudicated registries will be necessary to reliably identify factors associated with superior outcomes.
Source: Stroke - April 28, 2014 Category: Neurology Authors: Zacharia, B. E., Bruce, S. S., Carpenter, A. M., Hickman, Z. L., Vaughan, K. A., Richards, C., Gold, W. E., Lu, J., Appelboom, G., Solomon, R. A., Connolly, E. S. Tags: Health policy and outcome research, Cerebral Aneurysm, AVM, & Subarachnoid hemorrhage Clinical Sciences Source Type: research

Myeloperoxidase Is Increased in Human Cerebral Aneurysms and Increases Formation and Rupture of Cerebral Aneurysms in Mice Basic Sciences
Conclusions— These findings suggest that myeloperoxidase may contribute importantly to formation and rupture of CA.
Source: Stroke - May 22, 2015 Category: Neurology Authors: Chu, Y., Wilson, K., Gu, H., Wegman-Points, L., Dooley, S. A., Pierce, G. L., Cheng, G., Pena Silva, R. A., Heistad, D. D., Hasan, D. Tags: Cerebrovascular disease/stroke, Cerebral Aneurysm, AVM, & Subarachnoid hemorrhage Basic Sciences Source Type: research

Predictors of Outcome in Aneurysmal Subarachnoid Hemorrhage Patients Clinical Sciences
Background and Purpose—The mortality and morbidity after aneurysmal subarachnoid hemorrhage has improved because of better diagnosis, early treatment to secure the aneurysm, and better management of disease-specific complications. With these improvements in care, it is not clear if the previously identified independent predictors of a negative outcome have changed. The aim of this study was to identify the independent predictors of an unfavorable outcome (Glasgow Outcome Score 1, 2, and 3) in aneurysmal subarachnoid hemorrhage patients.Methods—Univariate and multivariate analysis of prospectively collected data on pati...
Source: Stroke - October 23, 2017 Category: Neurology Authors: James P. Galea, Louise Dulhanty, Hiren C. Patel Tags: Cerebral Aneurysm, Cerebrovascular Disease/Stroke Original Contributions Source Type: research

Flow Diversion Versus Conventional Treatment for Carotid Cavernous Aneurysms Clinical Sciences
Conclusions— The use of PED should be encouraged, especially in symptomatic patients. We found PED to be associated with less need for future treatment, higher improvement in symptoms rate, and lower rate of complications.
Source: Stroke - August 25, 2014 Category: Neurology Authors: Zanaty, M., Chalouhi, N., Starke, R. M., Barros, G., Saigh, M. P., Schwartz, E. W., Ajiboye, N., Tjoumakaris, S. I., Hasan, D., Rosenwasser, R. H., Jabbour, P. Tags: Cerebral Aneurysm, AVM, & Subarachnoid hemorrhage, Aneurysm, AVM, hematoma Clinical Sciences Source Type: research

Clipping and Coiling of Unruptured Intracranial Aneurysms Among Medicare Beneficiaries, 2000 to 2010 Clinical Sciences
Conclusions— Although outcomes tended to improve over time, increased preventative treatment of unruptured intracranial aneurysms among Medicare beneficiaries did not result in a population-level decrease in SAH rates.
Source: Stroke - August 24, 2015 Category: Neurology Authors: Jalbert, J. J., Isaacs, A. J., Kamel, H., Sedrakyan, A. Tags: Cerebral Aneurysm, AVM, & Subarachnoid hemorrhage, Aneurysm, AVM, hematoma Clinical Sciences Source Type: research