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NOR-SASS (Norwegian Sonothrombolysis in Acute Stroke Study) Clinical Sciences
Conclusions—CEST is safe among unselected ischemic stroke patients with or without a visible occlusion on computed tomography angiography and with varying grades of clinical severity. There was, however, statistically no significant clinical effect of sonothrombolysis in this prematurely stopped trial.Clinical Trial Registration—URL: http://www.clinicaltrials.gov. Unique identifier: NCT01949961.
Source: Stroke - January 22, 2017 Category: Neurology Authors: Aliona Nacu, Christopher E. Kvistad, Halvor Naess, Halvor Oygarden, Nicola Logallo, Jorg Assmus, Ulrike Waȷe–Andreassen, Kathinka D. Kurz, Gesche Neckelmann, Lars Thomassen Tags: Clinical Studies, Ischemia, Cerebrovascular Disease/Stroke, Ischemic Stroke Original Contributions Source Type: research

CLOTBUST-Hands Free: Pilot Safety Study of a Novel Operator-Independent Ultrasound Device in Patients With Acute Ischemic Stroke Clinical Sciences
Conclusions— Sonothrombolysis using a novel, operator-independent device, in combination with systemic tPA, seems safe, and recanalization rates warrant evaluation in a phase III efficacy trial. Clinical Trial Registration— URL: http://www.clinicaltrials.gov. Unique identifier: CLOTBUST-HF NCT01240356.
Source: Stroke - November 25, 2013 Category: Neurology Authors: Barreto, A. D., Alexandrov, A. V., Shen, L., Sisson, A., Bursaw, A. W., Sahota, P., Peng, H., Ardjomand-Hessabi, M., Pandurengan, R., Rahbar, M. H., Barlinn, K., Indupuru, H., Gonzales, N. R., Savitz, S. I., Grotta, J. C. Tags: Acute Cerebral Infarction, Doppler ultrasound, Transcranial Doppler etc., Thrombolysis, Other Stroke Treatment - Medical Clinical Sciences Source Type: research

Impact of Transcranial Doppler Ultrasound on Logistics and Outcomes in Stroke Thrombolysis Clinical Sciences
Background and Purpose—Diagnostic transcranial Doppler ultrasound (TCD) is commonly used in patients with acute stroke before or during treatment with intravenous thrombolysis (IVT). We aimed to assess how much TCD delays IVT initiation and whether TCD influences outcomes.Methods—We analyzed data from the SITS-ISTR (Safe Implementation of Thrombolysis in Stroke–International Stroke Thrombolysis Register) collected from December 2002 to December 2011. Outcomes were door-to-needle time, symptomatic intracerebral hemorrhage, functional outcome per the modified Rankin Scale, and mortality at 3 months.Results—In hospita...
Source: Stroke - June 25, 2018 Category: Neurology Authors: Michael V. Mazya, Niaz Ahmed, Elsa Azevedo, Antoni Davalos, Laura Dorado, Michal Karlinski, Svetlana Lorenzano, Jiři Neumann, Danilo Toni, Tiago P. Moreira Tags: Ultrasound, Health Services, Ischemic Stroke Original Contributions Source Type: research

Sickle Mice Are Sensitive to Hypoxia/Ischemia-Induced Stroke but Respond to Tissue-Type Plasminogen Activator Treatment Basic Sciences
Conclusions—Sickle mice are sensitive to hypoxia/ischemia-induced cerebral infarct but benefit from thrombolytic treatment. An increased resistive index in carotid arteries may be an early marker of sickle cell vasculopathy.
Source: Stroke - November 27, 2017 Category: Neurology Authors: Yu-Yo Sun, Jolly Lee, Henry Huang, Mary B. Wagner, Clinton H. Joiner, David R. Archer, Chia-Yi Kuan Tags: Animal Models of Human Disease, Basic Science Research Original Contributions Source Type: research

Association of Progression of Carotid Artery Wall Volume and Recurrent Transient Ischemic Attack or Stroke Clinical Sciences
Conclusions—The annual progression of carotid wall volume is independently associated with recurrent ischemic cerebrovascular events, and this measurement has added value for intraplaque hemorrhage and fibrous cap rupture in predicting future events.
Source: Stroke - February 26, 2018 Category: Neurology Authors: Mingming Lu, Peng Peng, Yuanyuan Cui, Huiyu Qiao, Dongye Li, Jianming Cai, Xihai Zhao Tags: Clinical Studies, Magnetic Resonance Imaging (MRI), Atherosclerosis Original Contributions Source Type: research

Intraplaque Hemorrhage, Fibrous Cap Status, and Microembolic Signals in Symptomatic Patients With Mild to Moderate Carotid Artery Stenosis: The Plaque At RISK Study Brief Reports
Conclusions— In patients with a symptomatic mild to moderate carotid artery stenosis, IPH and FC status are not associated with MES. This suggests that MRI and transcranial Doppler provide different information on plaque vulnerability. Clinical Trial Registration— URL: http://www.clinicaltrials.gov. Unique identifier: NCT01709045.
Source: Stroke - October 27, 2014 Category: Neurology Authors: Truijman, M. T. B., de Rotte, A. A. J., Aaslid, R., van Dijk, A. C., Steinbuch, J., Liem, M. I., Schreuder, F. H. B. M., van der Steen, A. F. W., Daemen, M. J. A. P., van Oostenbrugge, R. J., Wildberger, J. E., Nederkoorn, P. J., Hendrikse, J., van der Lu Tags: Imaging, Carotid Stenosis, Computerized tomography and Magnetic Resonance Imaging, Doppler ultrasound, Transcranial Doppler etc. Brief Reports Source Type: research

Time Course of Early Postadmission Hematoma Expansion in Spontaneous Intracerebral Hemorrhage Clinical Sciences
Conclusions— EHE was reliably reflected by transcranial B-mode ultrasound and mainly occurred within the first 7 to 8 hours after symptom onset. Clinical Trial Registration— URL: http://www.clinicaltrials.gov. Unique identifier: NCT01472224.
Source: Stroke - March 24, 2014 Category: Neurology Authors: Ovesen, C., Christensen, A. F., Krieger, D. W., Rosenbaum, S., Havsteen, I., Christensen, H. Tags: Acute Cerebral Hemorrhage, Doppler ultrasound, Transcranial Doppler etc., Intracerebral Hemorrhage Clinical Sciences Source Type: research

Comparing Vessel Imaging: Noncontrast Computed Tomography/Computed Tomographic Angiography Should Be the New Minimum Standard in Acute Disabling Stroke Topical Reviews
Source: Stroke - December 28, 2015 Category: Neurology Authors: Demchuk, A. M., Menon, B. K., Goyal, M. Tags: Angiography, Computerized Tomography (CT), Ultrasound, Cerebrovascular Procedures, Intracranial Hemorrhage Topical Reviews Source Type: research

Impaired Cerebral Autoregulation Is Associated With Vasospasm and Delayed Cerebral Ischemia in Subarachnoid Hemorrhage Clinical Sciences
Conclusions— Dynamic cerebral autoregulation is impaired in the early days after SAH. Including autoregulation as part of the initial clinical and radiographic assessment may enhance our ability to identify patients at a high risk for developing secondary complications after SAH.
Source: Stroke - February 24, 2014 Category: Neurology Authors: Otite, F., Mink, S., Tan, C. O., Puri, A., Zamani, A. A., Mehregan, A., Chou, S., Orzell, S., Purkayastha, S., Du, R., Sorond, F. A. Tags: Other diagnostic testing, Cerebral Aneurysm, AVM, & Subarachnoid hemorrhage, Doppler ultrasound, Transcranial Doppler etc., Other Research Clinical Sciences Source Type: research

Temporal Course of Dynamic Cerebral Autoregulation in Patients With Intracerebral Hemorrhage Clinical Sciences
Conclusions— In patients with supratentorial intracerebral hemorrhage, dynamic cerebral autoregulation is bilaterally impaired lasting at least 10 to 12 days and recovers within a month. Individual PD value is associated with clinical status at acute stage and affected-side PD on days 4 to 6 can be an independent predictor for clinical outcome.
Source: Stroke - February 22, 2016 Category: Neurology Authors: Ma, H., Guo, Z.-N., Liu, J., Xing, Y., Zhao, R., Yang, Y. Tags: Imaging, Ultrasound, Intracranial Hemorrhage Clinical Sciences Source Type: research