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Prospective, Randomized, Open-Label Phase II Trial on Concomitant Intraventricular Fibrinolysis and Low-Frequency Rotation After Severe Subarachnoid Hemorrhage Clinical Sciences
Conclusions— Despite the ineffectiveness on reduction of delayed cerebral ischemia or poor functional outcome, intraventricular fibrinolysis and kinetic therapy seems to be a safe and effective concept for therapeutic reduction of subarachnoid clot in a patient collective experiencing predominately severe subarachnoid hemorrhage. Therefore, future studies should investigate this treatment in a larger patient collective with a lower degree of primary brain injury and until full clot clearance on serial imaging. Clinical Trial Registration— URL: http://www.controlled-trials.com. Unique identifier: ICRCTN13230264.
Source: Stroke - July 22, 2013 Category: Neurology Authors: Etminan, N., Beseoglu, K., Eicker, S. O., Turowski, B., Steiger, H.-J., Hanggi, D. Tags: Emergency treatment of Stroke, Antiplatelets, Thrombolysis Clinical Sciences Source Type: research

Pediatric Cortical Vein Thrombosis: Frequency and Association With Venous Infarction Brief Reports
Conclusions— In our cohort, CVT was significantly associated with seizures at presentation, hemorrhage and restricted diffusion on acute imaging, as well as neurological disability and venous infarction at follow-up. Involvement of cortical veins in cerebral sinovenous thrombosis is associated with an increased risk of infarction and adverse outcome in children.
Source: Stroke - February 22, 2016 Category: Neurology Authors: Ritchey, Z., Hollatz, A. L., Weitzenkamp, D., Fenton, L. Z., Maxwell, E. C., Bernard, T. J., Stence, N. V. Tags: Pediatrics, Cerebrovascular Disease/Stroke Brief Reports Source Type: research

Use of Platelet Function Testing Before Pipeline Embolization Device Placement Clinical Sciences
Conclusions—Clopidogrel nonresponders experienced a significantly higher rate of thromboembolic complications when compared with clopidogrel responders. However, this risk seems to be mitigated in nonresponders who were switched to ticagrelor or received a clopidogrel boost within 24 hours pre-procedure.
Source: Stroke - April 24, 2017 Category: Neurology Authors: Nimer Adeeb, Christoph J. Griessenauer, Paul M. Foreman, Justin M. Moore, Hussain Shallwani, Rouzbeh Motiei-Langroudi, Abdulrahman Alturki, Adnan H. Siddiqui, Elad I. Levy, Mark R. Harrigan, Christopher S. Ogilvy, Ajith J. Thomas Tags: Treatment, Cerebral Aneurysm, Cerebrovascular Disease/Stroke, Cerebrovascular Procedures Original Contributions Source Type: research

Endovascular Therapy for Asymptomatic Unruptured Intracranial Aneurysms: JR-NET and JR-NET2 Findings Clinical Sciences
Conclusions— The radiographic results of EVT for asymptomatic UIAs in Japan were acceptable, with low mortality and morbidity rates.
Source: Stroke - September 23, 2013 Category: Neurology Authors: Shigematsu, T., Fujinaka, T., Yoshimine, T., Imamura, H., Ishii, A., Sakai, C., Sakai, N., for the JR-NET Investigators Tags: Aneurysm, AVM, hematoma Clinical Sciences Source Type: research

Impaired Cerebral Autoregulation Is Associated With Vasospasm and Delayed Cerebral Ischemia in Subarachnoid Hemorrhage Clinical Sciences
Conclusions— Dynamic cerebral autoregulation is impaired in the early days after SAH. Including autoregulation as part of the initial clinical and radiographic assessment may enhance our ability to identify patients at a high risk for developing secondary complications after SAH.
Source: Stroke - February 24, 2014 Category: Neurology Authors: Otite, F., Mink, S., Tan, C. O., Puri, A., Zamani, A. A., Mehregan, A., Chou, S., Orzell, S., Purkayastha, S., Du, R., Sorond, F. A. Tags: Other diagnostic testing, Cerebral Aneurysm, AVM, & Subarachnoid hemorrhage, Doppler ultrasound, Transcranial Doppler etc., Other Research Clinical Sciences Source Type: research