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Fibroblast Growth Factor 23 and Risk of Incident Stroke in Community-Living Adults Clinical Sciences
Conclusions— Higher FGF23 concentrations were associated with higher risk of cardioembolic but not with other stroke subtypes in community-dwelling adults. Additional studies should delineate reasons for these findings.
Source: Stroke - January 26, 2015 Category: Neurology Authors: Panwar, B., Jenny, N. S., Howard, V. J., Wadley, V. G., Muntner, P., Kissela, B. M., Judd, S. E., Gutierrez, O. M. Tags: Acute Cerebral Infarction, Embolic stroke, Epidemiology Clinical Sciences Source Type: research

Revised Framingham Stroke Risk Score, Nontraditional Risk Markers, and Incident Stroke in a Multiethnic Cohort Clinical Sciences
Conclusions—The R-FSRS downgraded stroke risk but had better calibration and discriminative ability for incident stroke compared with the original FSRS. Nontraditional risk markers modestly improved the discriminative ability of the R-FSRS, with coronary artery calcium performing the best.
Source: Stroke - January 22, 2018 Category: Neurology Authors: Peter Flueckiger, Will Longstreth, David Herrington, Joseph Yeboah Tags: Epidemiology, Primary Prevention, Race and Ethnicity, Risk Factors, Cerebrovascular Disease/Stroke Original Contributions Source Type: research

Inhibition of Calcium/Calmodulin-Dependent Protein Kinase Kinase {beta} and Calcium/Calmodulin-Dependent Protein Kinase IV Is Detrimental in Cerebral Ischemia Basic Sciences
Conclusions— Our data have established that the CaMKK/CaMK IV pathway is a key endogenous protective mechanism in ischemia. Our results suggest that this pathway serves as an important regulator of blood–brain barrier integrity and transcriptional activation of neuroprotective molecules in stroke.
Source: Stroke - August 26, 2013 Category: Neurology Authors: McCullough, L. D., Tarabishy, S., Liu, L., Benashski, S., Xu, Y., Ribar, T., Means, A., Li, J. Tags: Animal models of human disease Basic Sciences Source Type: research

Low Serum Calcium Levels Contribute to Larger Hematoma Volume in Acute Intracerebral Hemorrhage Brief Reports
Conclusions— Low admission serum calcium levels were associated with larger hematoma volume and higher National Institutes of Health Stroke Scale score among patients with acute intracerebral hemorrhage.
Source: Stroke - June 24, 2013 Category: Neurology Authors: Inoue, Y., Miyashita, F., Toyoda, K., Minematsu, K. Tags: Acute Cerebral Hemorrhage Brief Reports Source Type: research

Lower Serum Calcium Level Is Associated With Hemorrhagic Transformation After Thrombolysis Brief Reports
Conclusions— Lower admission serum calcium level is independently associated with HT after IVT, and this hypothesis needs larger confirmatory trials.
Source: Stroke - April 27, 2015 Category: Neurology Authors: Guo, Y., Yan, S., Zhang, S., Zhang, X., Chen, Q., Liu, K., Liebeskind, D. S., Lou, M. Tags: Thrombolysis Brief Reports Source Type: research

Rehabilitation Augments Hematoma Clearance and Attenuates Oxidative Injury and Ion Dyshomeostasis After Brain Hemorrhage Basic Sciences
Background and Purpose—We assessed the elemental and biochemical effects of rehabilitation after intracerebral hemorrhage, with emphasis on iron-mediated oxidative stress, using a novel multimodal biospectroscopic imaging approach.Methods—Collagenase-induced striatal hemorrhage was produced in rats that were randomized to enriched rehabilitation or control intervention starting on day 7. Animals were euthanized on day 14 or 21, a period of ongoing cell death. We used biospectroscopic imaging techniques to precisely determine elemental and molecular changes on day 14. Hemoglobin content was assessed with resonance Raman...
Source: Stroke - December 22, 2016 Category: Neurology Authors: Michael R. Williamson, Kristen Dietrich, Mark J. Hackett, Sally Caine, Colby A. Nadeau, Jasmine R. Aziz, Helen Nichol, Phyllis G. Paterson, Frederick Colbourne Tags: Basic Science Research, Mechanisms, Imaging, Intracranial Hemorrhage, Neuroprotectants Original Contributions Source Type: research

Dihydrolipoic Acid Inhibits Lysosomal Rupture and NLRP3 Through Lysosome-Associated Membrane Protein-1/Calcium/Calmodulin-Dependent Protein Kinase II/TAK1 Pathways After Subarachnoid Hemorrhage in Rat Basic Sciences
Conclusions—DHLA treatment improved neurofunction and alleviated inflammation through the lysosome-associated membrane protein-1/CaMKII/TAK1 pathway in early brain injury after SAH. DHLA may provide a promising treatment to alleviate early brain injury after SAH.
Source: Stroke - December 22, 2017 Category: Neurology Authors: Keren Zhou, Budbazar Enkhjargal, Zhiyi Xie, Chengmei Sun, Lingyun Wu, Jay Malaguit, Sheng Chen, Jiping Tang, Jianmin Zhang, John H. Zhang Tags: Animal Models of Human Disease, Basic Science Research, Inflammation, Ischemia, Mechanisms Original Contributions Source Type: research

Low Serum Calcium and Magnesium Levels and Rupture of Intracranial Aneurysms Brief Report
Conclusions—In this large case–control study, hypocalcemia and hypomagnesemia at diagnosis were significantly associated with ruptured aneurysms. Impaired hemostasis caused by hypocalcemia and hypomagnesemia may explain this association.
Source: Stroke - June 25, 2018 Category: Neurology Authors: Anil Can, Robert F. Rudy, Victor M. Castro, Dmitriy Dligach, Sean Finan, Sheng Yu, Vivian Gainer, Nancy A. Shadick, Guergana Savova, Shawn Murphy, Tianxi Cai, Scott T. Weiss, Rose Du Tags: Risk Factors, Cerebral Aneurysm Brief Reports Source Type: research