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Heterozygosity for ADP-ribosylation factor 6 suppresses the burden and severity of atherosclerosis
PLoS One. 2023 May 10;18(5):e0285253. doi: 10.1371/journal.pone.0285253. eCollection 2023.ABSTRACTAtherosclerosis is the root cause of major cardiovascular diseases (CVD) such as myocardial infarction and stroke. ADP-ribosylation factor 6 (Arf6) is a ubiquitously expressed GTPase known to be involved in inflammation, vascular permeability and is sensitive to changes in shear stress. Here, using atheroprone, ApoE-/- mice, with a single allele deletion of Arf6 (HET) or wildtype Arf6 (WT), we demonstrate that reduction in Arf6 attenuates atherosclerotic plaque burden and severity. We found that plaque burden in the descending...
Source: Atherosclerosis - May 10, 2023 Category: Cardiology Authors: Venkateswara R Gogulamudi Md Torikul Islam Jessica R Durrant Adelola O Adeyemo Daniel W Trott Mi Ho Hyuhn Weiquan Zhu Anthony J Donato Ashley E Walker Lisa A Lesniewski Source Type: research

Diet-Induced High Serum Levels of Trimethylamine-N-oxide Enhance the Cellular Inflammatory Response without Exacerbating Acute Intracerebral Hemorrhage Injury in Mice
This study was designed to explore the effects of TMAO on neuroinflammation, brain injury severity, and long-term neurologic function in mice with acute intracerebral hemorrhage (ICH). We fed mice with either a regular chow diet or a chow diet supplemented with 1.2% choline pre- and post-ICH. In this study, we measured serum levels of TMAO with ultrahigh-performance liquid chromatography-tandem mass spectrometry at 24 h and 72 h post-ICH. The expression level of P38-mitogen-protein kinase (P38-MAPK), myeloid differentiation factor 88 (MyD88), high-mobility group box1 protein (HMGB1), and interleukin-1β (IL-1β) around hem...
Source: Atherosclerosis - March 4, 2022 Category: Cardiology Authors: Caizhen Li Li Zhu Yinming Dai Zhiying Zhang Leo Huang Tom J Wang Peiji Fu Yinuo Li Jian Wang Chao Jiang Source Type: research