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Outcomes of endovascular treatment for acute large ‐vessel ischaemic stroke more than 6 h after symptom onset
ConclusionsIn appropriately selected patients, EVT >6 h was associated with comparable outcomes to those treated <6 h. These data support a physiological approach to patient selection.
Source: Journal of Internal Medicine - September 25, 2017 Category: Internal Medicine Authors: R. Motyer, H. K. Kok, H. Asadi, A. O'Hare, P. Brennan, S. Power, S. Looby, P. Nicholson, D. Williams, S. Murphy, M. D. Hill, M. Goyal, J. McManus, P. O'Brien, J. Thornton Tags: Original Article Source Type: research

Outcomes of endovascular treatment for acute large vessel ischemic stroke more than 6 hours after symptom onset
ConclusionsIn appropriately selected patients, EVT >6 hours was associated with comparable outcomes to those treated <6 hours. These data support a physiological approach to patient selection.This article is protected by copyright. All rights reserved.
Source: Journal of Internal Medicine - September 5, 2017 Category: Internal Medicine Authors: Ronan Motyer, Hong Kuan Kok, Hamed Asadi, Alan O'Hare, Paul Brennan, Sarah Power, Seamus Looby, Patrick Nicholson, David Williams, Sean Murphy, Michael D. Hill, Mayank Goyal, John McManus, Paul O'Brien, John Thornton Tags: Original Article Source Type: research

Management of acute ischaemic stroke in patients with dementia
Abstract An estimated 10% of stroke patients have an underlying dementia. As a consequence, health professionals often face the challenge of managing patients with dementia presenting with an acute stroke. Patients with dementia are less likely to receive thrombolysis (0.56–10% vs. 1–16% thrombolysis rates in the general population), be admitted to a stroke unit or receive some types of care. Anticoagulation for secondary stroke prevention is sometimes withheld, despite dementia not being listed as an exclusion criterion in current guidelines. Studies in this population are scarce, and results have been contradictory. ...
Source: Journal of Internal Medicine - February 1, 2017 Category: Internal Medicine Authors: A. Subic, P. Cermakova, B. Norrving, B. Winblad, M. Euler, M. G. Kramberger, M. Eriksdotter, S. Garcia ‐Ptacek Tags: Review Source Type: research

Glycaemic control and excess risk of ischaemic and haemorrhagic stroke in patients with type 1 diabetes: a cohort study of 33 453 patients
ConclusionsIndividuals with type 1 diabetes have an increased risk of ischaemic and haemorrhagic stroke, increasing markedly with poor glycaemic control.
Source: Journal of Internal Medicine - November 30, 2016 Category: Internal Medicine Authors: C. Hed én Ståhl, M. Lind, A.‐M. Svensson, S. Gudbjörnsdottir, A. Mårtensson, A. Rosengren Tags: Original Article Source Type: research

Randomized assessment of imatinib in patients with acute ischaemic stroke treated with intravenous thrombolysis
ConclusionThis phase II study showed that imatinib is safe and tolerable and may reduce neurological disability in patients treated with intravenous thrombolysis after ischaemic stroke. A confirmatory randomized trial is currently underway.
Source: Journal of Internal Medicine - October 31, 2016 Category: Internal Medicine Authors: N. Wahlgren, M. Thor én, B. Höjeberg, T.‐B. Käll, A.‐C. Laska, C. Sjöstrand, J. Höijer, H. Almqvist, S. Holmin, A. Lilja, L. Fredriksson, D. Lawrence, U. Eriksson, N. Ahmed Tags: Original Article Source Type: research

Preadmission use of selective serotonin reuptake inhibitors and short ‐term mortality in diabetic patients hospitalized due to stroke
ConclusionIn patients with diabetes, preadmission SSRI use was associated with increased mortality following ischaemic stroke, compared with nonuse.
Source: Journal of Internal Medicine - May 2, 2016 Category: Internal Medicine Authors: M. W ürtz, M. Schmidt, E. L. Grove, E. Horváth‐Puhó, C. F. Christiansen, H. T. Sørensen Tags: Original Article Source Type: research

Preadmission use of selective serotonin reuptake inhibitors and short‐term mortality in diabetic patients hospitalized due to stroke
ConclusionIn patients with diabetes, preadmission SSRI use was associated with increased mortality following ischaemic stroke, compared with nonuse.
Source: Journal of Internal Medicine - April 30, 2016 Category: Internal Medicine Authors: M. Würtz, M. Schmidt, E. L. Grove, E. Horváth‐Puhó, C. F. Christiansen, H. T. Sørensen Tags: Original Article Source Type: research

Alcohol and cardiovascular diseases: where do we stand today?
Abstract For centuries, multiple medical risks of heavy alcohol drinking have been evident with simultaneous awareness of a less harmful or sensible drinking limit. The increased risks of heavy drinking, defined as three or more standard‐sized drinks per day, are both cardiovascular (CV) and non‐CV. The CV risks include the following: (i) alcoholic cardiomyopathy (ACM), (ii) systemic hypertension, (iii) atrial arrhythmias, (iv) haemorrhagic stroke and, probably, ischaemic stroke. By contrast, modern epidemiological studies have shown lower morbidity and mortality amongst light–moderate drinkers, due mostly to a reduc...
Source: Journal of Internal Medicine - July 8, 2015 Category: Internal Medicine Authors: A. L. Klatsky Tags: Review Source Type: research

Treatment of acute stroke: an update
Abstract Stroke is the second leading cause of global mortality after coronary heart disease, and a major cause of neurological disability. About 17 million strokes occur worldwide each year. Patients with stroke often require long‐term rehabilitation following the acute phase, with ongoing support from the community and nursing home care. Thus, stroke is a devastating disease and a major economic burden on society. In this overview, we discuss current strategies for specific treatment of stroke in the acute phase, focusing on intravenous thrombolysis and mechanical thrombectomy. We will consider two important issues re...
Source: Journal of Internal Medicine - July 1, 2015 Category: Internal Medicine Authors: R. Mikulik, N. Wahlgren Tags: Review Source Type: research

Choosing the right drug to fit the patient when selecting oral anticoagulation for stroke prevention in atrial fibrillation
This article is protected by copyright. All rights reserved.
Source: Journal of Internal Medicine - March 1, 2015 Category: Internal Medicine Authors: Adrian M. Shields, Gregory Y. H. Lip Tags: Review Article Source Type: research

Dietary exposure to polychlorinated biphenyls is associated with increased risk of stroke in women
ConclusionDietary exposure to PCBs was associated with an increased stroke risk in women, especially hemorrhagic stroke. The results provide important information regarding the risk‐benefit analysis of fish consumption, particularly for cerebrovascular disease prevention.This article is protected by copyright. All rights reserved.
Source: Journal of Internal Medicine - January 16, 2014 Category: Internal Medicine Authors: Charlotte Bergkvist, Maria Kippler, Susanna C. Larsson, Marika Berglund, Anders Glynn, Alicja Wolk, Agneta Åkesson Tags: Original Source Type: research