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Enrollment Yield and Reasons for Screen Failure in a Large Prehospital Stroke Trial Brief Reports
Conclusions— In this large, multicenter prehospital trial, nearly 40% of every calls from the field to physician-investigators resulted in trial enrollments. The most common reasons for nonenrollment were out of window last known well time, prestroke confounding medical condition, and absence of a consent provider. Clinical Trial Registration— URL: http://www.clinicaltrials.gov. Unique identifier: NCT00059332.
Source: Stroke - December 28, 2015 Category: Neurology Authors: Kim, D.-H., Saver, J. L., Starkman, S., Liebeskind, D. S., Ali, L. K., Restrepo, L., Kim-Tenser, M., Valdes-Sueiras, M., Eckstein, M., Pratt, F., Stratton, S., Hamilton, S., Conwit, R., Sanossian, N., on behalf of the Field Administration of Stroke Therap Tags: Cardiopulmonary Resuscitation and Emergency Cardiac Care, Cerebrovascular Disease/Stroke, Intracranial Hemorrhage, Ischemic Stroke, Neuroprotectants Brief Reports Source Type: research

Paramedic Initiation of Neuroprotective Agent Infusions Clinical Sciences
Conclusions—Paramedic infusion initiation using gravity-controlled tubing permits rapid achievement of target serum levels of potential neuroprotective agents. The absence of association of clinical outcomes with achieved magnesium levels provides further evidence that magnesium is not biologically neuroprotective in acute stroke.
Source: Stroke - June 26, 2017 Category: Neurology Authors: Kristina Shkirkova, Sidney Starkman, Nerses Sanossian, Marc Eckstein, Samuel Stratton, Frank Pratt, Robin Conwit, Scott Hamilton, Latisha Sharma, David Liebeskind, Lucas Restrepo, Miguel Valdes-Sueiras, Jeffrey L. Saver Tags: Cerebrovascular Disease/Stroke, Neuroprotectants Original Contributions Source Type: research

Association Between Hyperacute Stage Blood Pressure Variability and Outcome in Patients With Spontaneous Intracerebral Hemorrhage Clinical Sciences
Conclusions—BPV during the hyperacute first minutes and hours after onset in patients with intracerebral hemorrhage was independently associated with poor functional outcome. Stabilization of BPV during this vulnerable period, in the pre-hospital and early emergency department course, is a potential therapeutic target for future clinical trials.Clinical Trial Registration—URL: http://www.clinicaltrials.gov. Unique identifier: NCT00059332.
Source: Stroke - January 22, 2018 Category: Neurology Authors: Pil-Wook Chung, Joon-Tae Kim, Nerses Sanossian, Sidney Starkmann, Scott Hamilton, Jeffrey Gornbein, Robin Conwit, Marc Eckstein, Frank Pratt, Sam Stratton, David S. Liebeskind, Jeffrey L. Saver Tags: High Blood Pressure, Intracranial Hemorrhage Original Contributions Source Type: research

Early Magnesium Treatment After Aneurysmal Subarachnoid Hemorrhage: Individual Patient Data Meta-Analysis Clinical Sciences
Conclusions— This meta-analysis suggests no beneficial effect of magnesium treatment on poor outcome or DCI when started early after SAH onset. Although the number of patients was small and a beneficial effect cannot be definitively excluded, we found no justification for a new trial with early magnesium treatment after SAH.
Source: Stroke - October 26, 2015 Category: Neurology Authors: Dorhout Mees, S. M., Algra, A., Wong, G. K. C., Poon, W. S., Bradford, C. M., Saver, J. L., Starkman, S., Rinkel, G. J. E., van den Bergh, W. M., on behalf of the writing groups of MASH-I, IMASH, MASH-II, MASH and FAST-MAG, Collaborators, van Kooten, Dirv Tags: Cerebral Aneurysm, AVM, & Subarachnoid hemorrhage, Neuroprotectors Clinical Sciences Source Type: research

Low Serum Calcium and Magnesium Levels and Rupture of Intracranial Aneurysms Brief Report
Conclusions—In this large case–control study, hypocalcemia and hypomagnesemia at diagnosis were significantly associated with ruptured aneurysms. Impaired hemostasis caused by hypocalcemia and hypomagnesemia may explain this association.
Source: Stroke - June 25, 2018 Category: Neurology Authors: Anil Can, Robert F. Rudy, Victor M. Castro, Dmitriy Dligach, Sean Finan, Sheng Yu, Vivian Gainer, Nancy A. Shadick, Guergana Savova, Shawn Murphy, Tianxi Cai, Scott T. Weiss, Rose Du Tags: Risk Factors, Cerebral Aneurysm Brief Reports Source Type: research