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Changes in Serum Growth Factors in Stroke Rehabilitation Patients and Their Relation to Hemiparesis Improvement
Predicting recovery from hemiparesis after stroke is important for rehabilitation. A few recent studies reported that the levels of some growth factors shortly after stroke were positively correlated with the clinical outcomes during the chronic phase. The aim of this study was to examine the relationships between the serum levels of growth factors (vascular endothelial growth factor [VEGF], insulin-like growth factor-I [IGF-I], and hepatocyte growth factor [HGF]) and improvement in hemiparesis in stroke patients who received rehabilitation in a postacute rehabilitation hospital. Subjects were 32 stroke patients (cerebral ...
Source: Journal of Stroke and Cerebrovascular Diseases - April 25, 2014 Category: Neurology Authors: Hideto Okazaki, Hidehiko Beppu, Kenmei Mizutani, Sayaka Okamoto, Shigeru Sonoda Tags: Original Articles Source Type: research

Insulin-Like Growth Factor 2 (IGF-2) Regulates Neuronal Density and IGF-2 Distribution Following Hippocampal Intracerebral Hemorrhage
Memory is the most critical cognitive function in humans. Hippocampus infarcts and artery lesions in stroke and trauma cause levels of memory loss, and it is an apparent cause of disability in the communities.1,2 Intracerebral Hemorrhage (ICH) caused by bleeding in the brain parenchyma and penetration of the hematoma into the hippocampus leads to severe memory damage.3,4 Many arteries supply the hippocampus, most of which branch off of the posterior cerebral artery, the anterior temporal, and the anterior choroidal arteries.
Source: Journal of Stroke and Cerebrovascular Diseases - August 11, 2020 Category: Neurology Authors: Farzaneh Vafaee, Asadollah Zarifkar, Masoumeh Emamghoreishi, Mohammad Reza Namavar, Shima Shirzad, Hamed Ghazavi, Vahid Mahdavizadeh Source Type: research

Potential Application of Intranasal Insulin Delivery for Treatment of Intracerebral Hemorrhage: A Review of The Literature
Intracerebral hemorrhage (ICH) is a devastating subtype of stroke associated with high morbidity and mortality that is considered a medical emergency, mainly managed with adequate blood pressure control and creating a favorable hemostatic condition. However, to date, none of the randomized clinical trials have led to an effective treatment for ICH. It is vital to better understand the mechanisms underlying brain injury to effectively decrease ICH-associated morbidity and mortality. It is well known that initial hematoma formation and its expansion have detrimental consequences.
Source: Journal of Stroke and Cerebrovascular Diseases - April 27, 2022 Category: Neurology Authors: Muhammad Ali Javaid, Magdy Selim, Santiago Ortega-Gutierrez, Simona Lattanzi, Shima Zargar, Danielle A Alaouieh, Emily Hong, Afshin A. Divani Tags: Review Article Source Type: research