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E-107 Carotid artery stenting in patients with symptomatic non-stenotic carotid artery disease - a case series
ConclusionsIn this case series performed over a 10-year period at a high-volume stroke center we show that CAS is safe and efficient in patients with SyNC. Previous studies have established safety and effectiveness of CES in patients presenting with SyNC, however there is a paucity of reports in the literature regarding the effect of CAS in this patient population. Recent guidelines have brought specific attention to high-risk plaque characteristics which suggest that plaque instability plays a major role in the onset of ischemic events, regardless of lumen narrowing. Advanced imaging techniques, such as Optical Coherence ...
Source: Journal of NeuroInterventional Surgery - July 30, 2023 Category: Neurosurgery Authors: Nedelcu, S., Kuhn, A., Singh, J., Puri, A. Tags: SNIS 20th annual meeting electronic poster abstracts Source Type: research

E-132 Successful mechanical thrombectomy in an 11-year-old patient with emergent large vessel occlusion acute ischemic stroke related to congenital complete heart block and recent covid-19 infection
ConclusionsThis is a first known report of a successful mechanical thrombectomy in a pediatric patient due to a large vessel occlusion related to congenital complete heart block and recent COVID-19 infection.Disclosures J. Ansari: None. D. Mata Canadas: None. M. Ayub: None. J. Caskey: None. P. Simoncini: None. R. Riel-Romero: None. P. Sharma: None. D. Jordan: None. H. Cuellar: None.
Source: Journal of NeuroInterventional Surgery - July 30, 2023 Category: Neurosurgery Authors: Ansari, J., Mata Canadas, D., Ayub, M., Caskey, J., Simoncini, P., Riel-Romero, R., Sharma, P., Jordan, D., Cuellar, H. Tags: SNIS 20th annual meeting electronic poster abstracts Source Type: research

E-142 A new graphical interface to capture quantitative venous outflow metrics
ConclusionsOur newly developed graphical interface allows users to output quantitative metrics that may represent AIF and VOF. These metrics should be checked against existing scales for association and performance.Abstract E-142 Figure 1Disclosures G. Adusumilli: None. S. Christensen: 2; C; iSchemaView. 4; C; iSchemaView. T. Faizy: None. G. Albers: 2; C; iSchemaView, Genentech. 4; C; iSchemaView. M. Lansberg: None. J. Heit: 2; C; Medtronic, MicroVention. 6; C; iSchemaView.
Source: Journal of NeuroInterventional Surgery - July 30, 2023 Category: Neurosurgery Authors: Adusumilli, G., Christensen, S., Faizy, T., Albers, G., Lansberg, M., Heit, J. Tags: SNIS 20th annual meeting electronic poster abstracts Source Type: research

E-150 Mechanical thrombectomy in distal middle cerebral artery occlusions using a novel blind exchange mini-pinning technique: experience in 7 consecutive cases
ConclusionBlind mini-pinning allows for combined use of distal stentriever with a 035 thrombectomy catheter, affording a larger ID than traditional microcatheter engagement of the thrombus with enhanced stability for removal, and improved reperfusion rates in distal occlusions. This technique may be efficacious for the treatment of distal occlusions and further studies are needed to compare outcomes in distal occlusions.Abstract E-150 Figure 1(A) Deployment and blind mini-pinning navigation of 035 aspiration catheter (blue) through 071 (black) and 088 thrombectomy catheter (orange) into the M2 segment with follow-up angiog...
Source: Journal of NeuroInterventional Surgery - July 30, 2023 Category: Neurosurgery Authors: Meyer, B., Campos, J., Zarrin, D., Khan, M., Collard de Beaufort, J., Amin, G., Golshani, K., Beaty, N., Bender, M., Colby, G., Lin, L., Coon, A. Tags: SNIS 20th annual meeting electronic poster abstracts Source Type: research

E-152 Cone-beam CT angiogram acquisition in the angiography suite for LVO detection in acute ischemic stroke
ConclusionDTAS triage workflow with cone-beam head CT and CTA image acquisition in the angiography suite may be a next step to further optimize LVO stroke pathways by bypassing conventional CT/MR. This new workflow has the potential to further decrease door-to-needle times and thereby may improve patient outcome.Disclosures A. Kuhn: None. J. Singh: None. M. Garcia: None. S. Sarid: None. M. Gounis: 1; C; National Institutes of Health (NIH), the United States – Israel Binational Science Foundation, Anaconda, ApicBio, Arsenal Medical, Axovant, Balt, Cerenovus, Ceretrieve, CereVasc LLC, Cook Medical, Gal. 2; C; fee-per-h...
Source: Journal of NeuroInterventional Surgery - July 30, 2023 Category: Neurosurgery Authors: Kuhn, A., Singh, J., Garcia, M., Sarid, S., Gounis, M., Anagnostakou, V., Puri, A. Tags: SNIS 20th annual meeting electronic poster abstracts Source Type: research

O-010 Tigertriever in the treatment of acute ischemic stroke in patients with underlying intracranial atherosclerotic disease
ConclusionTigertriever exerts a higher radial force that can be manually tailored to achieve better recanalization in patients with LVO due to ICAD.ReferenceGupta R, Saver JL, Levy E, et al. New class of radially adjustable stentrievers for acute ischemic stroke: primary results of the multicenter TIGER trial. Stroke. May 2021;52(5):1534-1544. doi:10.1161/strokeaha.121.034436Abstract O-010 Figure 1(A) A right Ml occlusion due to underlying ICAD (arrowhead). (B) The Tigertriever is deployed across the stenosis. The device ‘massages’ the thrombus and exerts an increased radial force in stenotic lesions due to ICA...
Source: Journal of NeuroInterventional Surgery - July 30, 2023 Category: Neurosurgery Authors: Ojeda, D., Sanchez, S., Miller, J., Almajali, M., Koul, P., Noboa, L., Ghannam, M., Samaniego, E. Tags: SNIS 20th annual meeting oral abstracts Source Type: research

O-012 Relationship between clot composition and procedural results for ischemic stroke aspiration thrombectomy: subset analysis from the INSIGHT registry
ConclusionsClot removed during neuroendovascular procedures can differ in consistency and removability, leading to an increased focus on thrombus composition as a crucial variable for improving outcomes of ischemic stroke. In this study, good final revascularization (mTICI 2b-3 at the final angiogram) occurred after aspiration thrombectomy regardless of clot composition. Ongoing analysis of collected specimens is expected to provide valuable information regarding thrombus biology and etiology and to aid in diagnosis, prognosis, and drug development.Abstract O-012 Table 1Clot composition vs procedural results for ischemic s...
Source: Journal of NeuroInterventional Surgery - July 30, 2023 Category: Neurosurgery Authors: Kellner, C., Dabney, A., Baltan, S., Sohrabji, F., Pennypacker, K., Nanda, A., Woodward, K., Rivet, D., Fraser, J. Tags: SNIS 20th annual meeting oral abstracts Source Type: research

O-017 Viz LVO versus rapid LVO in detection of large vessel occlusion on computed tomography angiography for acute stroke
ConclusionViz LVO and Rapid LVO had similar NPV, but Rapid LVO produced a significantly larger number of false positive values. False positive values can be a source of alarm desensitization, leading to missed alarms or delayed responses. EF and intracranial atherosclerosis were significant predictors of incorrect predictions in both software packages. We hope this data will be used to improve future algorithms.Disclosures A. Delora: None. C. Hadjialiakbari: None. E. Percenti: None. A. Hassan: 1; C; LVO SYNCHRONIZE-Viz.ai. 2; C; Viz.ai. Y. Alderazi: None. J. Torres: None. M. Ezzeldin: None.
Source: Journal of NeuroInterventional Surgery - July 30, 2023 Category: Neurosurgery Authors: Delora, A., Hadjialiakbari, C., Percenti, E., Hassan, A., Alderazi, Y., Torres, J., Ezzeldin, M. Tags: SNIS 20th annual meeting oral abstracts Source Type: research

O-063 First U.S. multicenter experience using the pipeline flex embolization device with shield technology for treatment of intracranial aneurysms
ConclusionOur study is the first to report the early experience with the newly FDA-approved PED Flex with Shield technology amongst US centers. Our results are comparable with non-US, international studies showing a high technical success rate and safe peri-procedural angiographic and patient outcome. Longer follow-up will be needed to provide more robust data on angiographic and patient outcomes.Disclosures A. Kuhn: None. J. Singh: None. A. Abdelsalam: None. V. Saini: None. J. Burks: None. G. Cortez: None. R. Abbas: None. M. Pervez: None. H. Saei: None. S. Burke: None. M. Salem: None. J. Vivanco-Suarez: None. R. Kutcher-D...
Source: Journal of NeuroInterventional Surgery - July 30, 2023 Category: Neurosurgery Authors: Kuhn, A., Singh, J., Abdelsalam, A., Saini, V., Burks, J., Cortez, G., Abbas, R., Pervez, M., Saei, H., Burke, S., Salem, M., Vivanco-Suarez, J., Kutcher-Diaz, R., Bounajem, M., Naragum, V., Massari, F., Marwah, S., Gounis, M., Hassan, A., Malek, A., Dabu Tags: SNIS 20th annual meeting oral abstracts Source Type: research

P-005 Predictors for large vessel recanalization before stroke thrombectomy
ConclusionsIVT at least 1.5 hours before angiography, site of vascular occlusion, atrial fibrillation, and hyperlipidemia are independent predictors for LVR. The 8-point Recan score proposed in this study may be a valuable tool for predicting LVR before EVT.Abstract P-005 Figure 1Disclosures H. Chen: None. M. Colasurdo: None. C. Schrier: None. M. Khalid: None. M. Khunte: None. T. Miller: None. J. Cherian: None. A. Malhotra: None. D. Gandhi: 1; C; National Institutes of Health, Focused Ultrasound Foundation, MicroVention, University of Calgary, University of Maryland Medical Center.
Source: Journal of NeuroInterventional Surgery - July 30, 2023 Category: Neurosurgery Authors: Chen, H., Colasurdo, M., Schrier, C., Khalid, M., Khunte, M., Miller, T., Cherian, J., Malhotra, A., Gandhi, D. Tags: SNIS 20th annual meeting oral poster abstracts Source Type: research

P-024 Diffuse correlation spectroscopy in acute ischemic stroke neurointerventional procedures; initial experience and preliminary results
ConclusionsWe showed the feasibility of this non-invasive approach in providing continuous measurement of regional CBF brain tissue properties. In the future, implementations of more robust DCS instruments such as our recently developed pathlength-resolved DCS device could alleviate the limitations of the current DCS technology discovered during this study.Abstract P-024 Figure 1Disclosures M. Mokin: 1; C; NIH NINDS. 2; C; Cerenovus, Medtronic. 4; C; Bendit Technologies, Borvo medical, BrainQ, Endostream, Serenity medical, Synchron, Sim&Cure, QAS.AI, Quantanosis.AI. S. Thanki: None. P. Mohammad: None. S. Sheehy: None. ...
Source: Journal of NeuroInterventional Surgery - July 30, 2023 Category: Neurosurgery Authors: Mokin, M., Thanki, S., Mohammad, P., Sheehy, S., Jones, K., Peto, I., Guerrero, W., Vakharia, K., Burgin, W., Parthasarathy, A. Tags: SNIS 20th annual meeting oral poster abstracts Source Type: research

P-026 Extracellular vesicle neurotrophin expression in plasma collected during mechanical thrombectomy from patients with emergent large vessel stroke
DiscussionThese data suggest that EV proBDNF/BDNF levels can reflect vascular changes that lead to decreased cognition and should be explored further for translational applications.Disclosures A. Trout: None. D. Britsch: None. W. Naberhaus: None. J. Turchan-Cholewo: None. C. McLouth: None. L. Whitnel-Smith: None. J. Frank: None. J. Roberts: None. P. Shivani: None. D. Dornboss III: None. J. Harp: None. K. Pennypacker: None. A. Stowe: None. J. Fraser: None.
Source: Journal of NeuroInterventional Surgery - July 30, 2023 Category: Neurosurgery Authors: Trout, A., Britsch, D., Naberhaus, W., Turchan-Cholewo, J., McLouth, C., Whitnel-Smith, L., Frank, J., Roberts, J., Shivani, P., Dornboss, D., Harp, J., Pennypacker, K., Stowe, A., Fraser, J. Tags: SNIS 20th annual meeting oral poster abstracts Source Type: research

E-006 U.S. health care system-wide transition from alteplase to tenecteplase before mechanical thrombectomy: functional outcomes, early reperfusion rates, intracranial bleeding and femoral access site complications
ConclusionsThe first-year experience demonstrates the effectiveness and safety of the transitioning from TPA to TNK. The higher early recanalization rates with TNK are striking. Additional studies are required to investigate whether TNK is superior to TPA in the setting of LVO stroke.Disclosures M. Collins: None. C. Schirmer: None. G. Weiner: None. O. Goren: None. I. Melamed: None. S. Dalal: None. M. Kole: None. A. Noto: None. P. Hendrix: None.
Source: Journal of NeuroInterventional Surgery - July 30, 2023 Category: Neurosurgery Authors: Collins, M., Schirmer, C., Weiner, G., Goren, O., Melamed, I., Dalal, S., Kole, M., Noto, A., Hendrix, P. Tags: SNIS 20th annual meeting electronic poster abstracts Source Type: research

E-012 Reasons for choosing nondominant vertebral artery as an access route in hyperacute vertebrobasilar ischemic stroke
ConclusionsUndoubtedly, the fastest treatment is best through the dominant VA. Nondominant VA may be another option in situations where it is accessible, stable, or less risky despite nonvisualized VA in angiogram.Disclosures G. Lee: None. C. Yang: None. C. Kang: None. J. Kim: None. J. Joo: None. Y. Chung: None. J. Huh: None. J. Rhim: None.
Source: Journal of NeuroInterventional Surgery - July 30, 2023 Category: Neurosurgery Authors: Lee, G., Yang, C., Kang, C., Kim, J., Joo, J., Chung, Y., Huh, J., Rhim, J. Tags: SNIS 20th annual meeting electronic poster abstracts Source Type: research

E-044 Long-term safety and efficacy of pipeline embolization device compared in anterior and posterior circulation aneurysms: a systematic review and meta-analysis
ConclusionThe long-term occlusion rate after PED was higher in AC aneurysms and the cumulative incidence of ischemic complications and aneurysm rupture was significantly higher in PC. The intracranial hemorrhage rate was not different. More extensive studies are required to identify factors predisposing to incomplete occlusion and postprocedural complications.Disclosures E. Greco: None. A. Ghaith: None. J. Rios-Zermeno: None. M. Ghanem: None. C. Perez- Vega: None. S. Kashyap: None. D. Freeman: None. E. Middlebrooks: None. S. Sandhu: None. M. Bydon: None. R. Tawk: None.
Source: Journal of NeuroInterventional Surgery - July 30, 2023 Category: Neurosurgery Authors: Greco, E., Ghaith, A., Rios-Zermeno, J., Ghanem, M., Perez- Vega, C., Kashyap, S., Freeman, D., Middlebrooks, E., Sandhu, S., Bydon, M., Tawk, R. Tags: SNIS 20th annual meeting electronic poster abstracts Source Type: research

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