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Source: Neuroscience Letters
Condition: Ischemic Stroke
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Total 63 results found since Jan 2013.
Association of APOE (E2, E3 and E4) gene variants and lipid levels in ischemic stroke, its subtypes and hemorrhagic stroke in a South Indian population
In conclusion, our results suggest that APOE polymorphism does seem to play a role in hemorrhagic stroke and also in the development of specific subtypes of ischemic stroke. Further, in ischemic stroke VLDL and triglycerides levels were found to be significantly associated with E2/E4 and E3/E4 genotypes.
Source: Neuroscience Letters - June 28, 2016 Category: Neuroscience Source Type: research
Micro RNA 181c-5p: a promising target for post-stroke recovery in socially isolated mice
Publication date: Available online 10 November 2019Source: Neuroscience LettersAuthor(s): Maria Antony, Victoria Scranton, Pranay Srivastava, Rajkumar VermaAbstractDysregulation of microRNAs (miRNAs) has been tied to several neurological disorders, including ischemic stroke. It has also been established that social environments can modulate miRNA profiles. We have previously shown that post-stroke social isolation (SI) is linked to poor stroke outcomes and that miR-181c-5p emerged as one of few lead miRNAs that was downregulated in both stroke and SI. Therefore, in this study we examined the potential role of miR-181c-5p m...
Source: Neuroscience Letters - November 11, 2019 Category: Neuroscience Source Type: research
Ischemic stroke damages the intestinal mucosa and induces alteration of the intestinal lymphocytes and CCL19 mRNA in rats
This study showed that ischemic stroke significantly damaged the intestinal epithelium and activated intestinal immunity.
Source: Neuroscience Letters - August 31, 2017 Category: Neuroscience Source Type: research
Circulating Aquaporin-4 as a biomarker of early neurological improvement in stroke patients: a pilot study
Publication date: Available online 28 October 2019Source: Neuroscience LettersAuthor(s): Laura Ramiro, Alba Simats, Anna Penalba, Alvaro Garcia-Tornel, Alex Rovira, Fernando Mancha, Alejandro Bustamante, Joan MontanerAbstractPatients’ outcome prediction after ischemic stroke is still challenging. Aquaporin-4 (AQP4) is a water channel that is up-regulated in the brain after the ischemic event, but its presence in bloodstream of stroke patients has not been previously studied. The aim of this pilot study was to investigate circulating AQP4 levels after stroke and its correlation with infarct growth and neurological outcome...
Source: Neuroscience Letters - October 30, 2019 Category: Neuroscience Source Type: research
Neurofilament changes in serum and cerebrospinal fluid after acute ischemic stroke
ConclusionNFL and pNFH in CSF and serum are promising biomarkers for axonal injury following stroke. Further studies in larger populations are needed to fully understand the progression of the neuronal damage after acute ischemic stroke and to evaluate if these biomarkers can provide additive information and how they relate to outcome.
Source: Neuroscience Letters - December 30, 2018 Category: Neuroscience Source Type: research
Bone marrow mesenchymal stem cells-conditioned medium enhances vascular remodeling after stroke in type 2 diabetic rats
In conclusion, enhanced expression of Ang1 and Tie2 in ischemic brain after BMSCs-CM treatment of stroke may contribute to the improved functional recovery after stroke in type 2 diabetic rats.
Source: Neuroscience Letters - February 26, 2017 Category: Neuroscience Source Type: research
The mTOR cell signaling pathway is crucial to the long-term protective effects of ischemic postconditioning against stroke
Publication date: 29 May 2018 Source:Neuroscience Letters, Volume 676 Author(s): Peng Wang, Rong Xie, Michelle Cheng, Robert Sapolsky, Xunming Ji, Heng Zhao Ischemic postconditioning (IPostC) protects against stroke, but few have studied the pathophysiological mechanisms of its long-term protective effects. Here, we investigated whether the mTOR pathway is involved in the long-term protective effects of IPostC. Stroke was induced in rats by distal middle cerebral artery occlusion (dMCAo) combined with 30 min of bilateral common carotid artery (CCA) occlusion, and IPostC was induced after the CCA release. Injury size and...
Source: Neuroscience Letters - April 25, 2018 Category: Neuroscience Source Type: research
Visual processing features in patients with visual spatial neglect recovering from right-hemispheric stroke
ConclusionsOur findings support the use of the event-related potential as a tool for investigating rapid recovery from VSN after stroke and suggest that other factors, such as an asymmetrical omission toward the contralateral side or impairment in the temporal processing capacity, might also be potential biomarkers of recovery.
Source: Neuroscience Letters - October 2, 2019 Category: Neuroscience Source Type: research
Stroke promotes survival of nearby transplanted neural stem cells by decreasing their activation of caspase 3 while not affecting their differentiation
Publication date: 14 February 2018 Source:Neuroscience Letters, Volume 666 Author(s): Nina Kosi, Ivan Alić, Iva Salamon, Dinko Mitrečić Although transplantation of stem cells improves recovery of the nervous tissue, little is known about the influence of different brain regions on transplanted cells. After we confirmed that cells with uniform differentiation potential can be generated in independent experiments, one million of neural stem cells isolated from B6.Cg-Tg(Thy1-YFP)16Jrs/J mouse embryos were transplanted into the brain 24 h after induction of stroke. The lateral ventricles, the corpus callosum and the stri...
Source: Neuroscience Letters - January 4, 2018 Category: Neuroscience Source Type: research
Intraventricular Infusion of a Low Fraction of Serum Enhances Neurogenesis and Improves Recovery in a Rodent Stroke Model
In this study, we further evaluated the efficacy of intraventricular administration of 100K with bFGF (100K/bFGF) in a rat model of transient middle cerebral artery occlusion (MCAO). Rats administered 100K/bFGF on post-stroke day 1 exhibited a higher number of Ki67 and Nestin immunoreactive cells at the subventricular zone (SVZ) area and in the infarcted brain, indicating promotion of NSPCs proliferation. The 100K/bFGF treatment also predominantly increased the number of MAP-2 immunoreactive cells rather than GFAP immunoreactive cells at the SVZ area and in the infarcted regions, implying that 100K/bFGF dominated NSPCs dif...
Source: Neuroscience Letters - November 20, 2015 Category: Neuroscience Source Type: research
Transgenic expression of HuR increases vasogenic edema and impedes functional recovery in rodent ischemic stroke
Conclusions Ectopic expression of HuR in astrocytes worsens outcome after transient ischemic stroke in mice in part by increasing vasogenic cerebral edema. These findings suggest that HuR could be a therapeutic target in cerebral ischemia/reperfusion.
Source: Neuroscience Letters - October 7, 2017 Category: Neuroscience Source Type: research
Simultaneous alterations of oligodendrocyte-specific CNP, astrocyte-specific AQP4 and neuronal NF-L demarcate ischemic tissue after experimental stroke in mice
In conclusion, the present study provides evidence for a simultaneous affection of oligodendrocytes, astrocytes and neurons after experimental focal cerebral ischemia. Consequently, CNP, AQP4 and NF-L immunofluorescence alterations can be utilized to identify ischemia-affected tissue. The simultaneity of the described alterations further strengthens the concept of interdependent NVU components and distinguishes NF-L, CNP and AQP4 as highly ischemia-sensitive elements. Consequently, future therapeutic approaches might influence stroke evolution via strategies simultaneously addressing both neuronal and glial functions.
Source: Neuroscience Letters - July 31, 2019 Category: Neuroscience Source Type: research
ELR-CXC chemokine antagonism is neuroprotective in a rat model of ischemic stroke
Publication date: 8 October 2015 Source:Neuroscience Letters, Volume 606 Author(s): Barry J. Connell, John R. Gordon, Tarek M. Saleh Inflammation-related cerebral damage mediated by infiltrating neutrophils following reperfusion plays a role in reperfusion-induced brain damage subsequent to a stroke event. The ELR-CXC family of chemokines are CXCR1 and CXCR2 agonists that are known to drive neutrophil migration and activation. The present study demonstrated the benefit of anti-inflammatory therapy in the treatment of ischemic stroke with the administration of the competitive ELR-CXC chemokine antagonist, CXCL8(3–72)...
Source: Neuroscience Letters - September 4, 2015 Category: Neuroscience Source Type: research
Hyperglycemia decreases expression of 14-3-3 proteins in an animal model of stroke
This study investigated 14-3-3 proteins expression in the cerebral cortex of animals with diabetes, cerebral ischemic injury and a combination of both diabetes and cerebral ischemic injury. Diabetes was induced by intraperitoneal injection of streptozotocin (40mg/kg) in adult male rats. After 4 weeks of treatment, middle cerebral artery occlusion (MCAO) was performed for the induction of focal cerebral ischemia and cerebral cortex tissue was collected 24h after MCAO. We confirmed that diabetes increases infarct volume following MCAO compared to non-diabetic animals. In diabetic animals with MCAO injury, reduction of 14-3-3...
Source: Neuroscience Letters - May 24, 2016 Category: Neuroscience Source Type: research
GC-MS-based Metabolomics Identifies an Amino Acid Signature of Acute Ischemic Stroke
Publication date: Available online 19 January 2017 Source:Neuroscience Letters Author(s): Dian Wang, Jing Kong, Jiayan Wu, Xingxing Wang, Minchao Lai Ischemic stroke is a serious public health problem worldwide. Here, we characterized the metabolite features of acute ischemic stroke (AIS) using a gas chromatography-mass spectrometry-based metabolomics. Forty AIS patients and 29 sex and age-matched controls were recruited. The serum metabolic profiles were significantly different between the two groups. Compared to the controls, the patients had elevated levels of lactate, carbonate and glutamate (P<0.01), and lower...
Source: Neuroscience Letters - January 18, 2017 Category: Neuroscience Source Type: research
