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Source: Journal of Neurochemistry
Condition: Ischemic Stroke

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Total 82 results found since Jan 2013.

Dense dopaminergic innervation of the peri ‐infarct cortex despite dopaminergic cell loss after a pure motor‐cortical stroke in rats
In this study, we assessed the reorganization of dopaminergic innervation of the PIC in a rat model of focal cortical stroke. Our data suggest a sprouting of dopaminergic fibers into the PIC and point to a role for dopaminergic signaling in reparative mechanisms post-stroke, potentially related to recovery. AbstractAfter ischemic stroke, the cortex directly adjacent to the ischemic core (i.e., the peri-infarct cortex, PIC) undergoes plastic changes that facilitate motor recovery. Dopaminergic signaling is thought to support this process. However, ischemic stroke also leads to the remote degeneration of dopaminergic midbrai...
Source: Journal of Neurochemistry - September 22, 2023 Category: Neuroscience Authors: Sibylle Frase, Julius Steddin, Enya Paschen, Maximilian Lenz, Pasquale Conforti, Carola A. Haas, Andreas Vlachos, Christian Schachtrup, Jonas A. Hosp Tags: ORIGINAL ARTICLE Source Type: research

Gene expression profiling in whole blood stimulated ex vivo with lipopolysaccharide as a tool to predict post ‐stroke depressive symptoms: Proof‐of‐concept study
We studied if blood gene expression could facilitate identification of persons who will develop depression 3 months after ischemic stroke. Venous blood samples were collected on day 3 after stroke. Obtained blood was stimulated in vitro with lipopolysaccharide, a powerful inducer of gene expression. After stimulation, RNA was isolated and sequenced. Expression of 510 genes differed between patients who developed depression and those who had not depression after stroke. Bioinformatic analysis revealed that expression of 6 genes (PKM, PRRC2C, NUP188, CHMP3, H2AC8, NOP10) accurately predicted a risk of depression. Our finding...
Source: Journal of Neurochemistry - June 27, 2023 Category: Neuroscience Authors: Marcin Piechota, Dzesika Hoinkis, Michal Korostynski, Slawomir Golda, Joanna Pera, Tomasz Dziedzic Tags: ORIGINAL ARTICLE Source Type: research

Modulation of the autophagy ‐lysosomal pathway and endoplasmic reticulum stress by ketone bodies in experimental models of stroke
We report for the first time that the protective effect of β-hydroxybutyrate (BHB) against stroke and glucose deprivation is enantiomer selective. We discovered that D-BHB treatment prevented the cleavage of the lysosomal membrane protein LAMP2, maintained lysosome integrity and stimulated the autophagic flux. Also, D-BHB notably reduced the activation of the PERK and IRE1α branches of the unfolded protein response (UPR), attenuating protein synthesis inhibition and preventing endoplasmic reticulum stress. Together our results support the therapeutic use of D-BHB treatment post-ischemia, by preventing the loss of proteos...
Source: Journal of Neurochemistry - June 17, 2023 Category: Neuroscience Authors: Teresa Montiel, Juan Carlos G ómora‐García, Cristian Gerónimo‐Olvera, Yessica Heras‐Romero, Berenice N. Bernal‐Vicente, Xochitl Pérez‐Martínez, Luis B. Tovar‐y‐Romo, Lourdes Massieu Tags: ORIGINAL ARTICLE Source Type: research

Astragaloside IV alleviates neuronal ferroptosis in ischemic stroke by regulating fat mass and obesity ‐associated—N6‐methyladenosine—acyl‐CoA synthetase long‐chain family member 4 axis
Ischemic stroke (IS) is a detrimental neurological disease with limited treatments options. Astragaloside IV (As-IV) was a promising bioactive constituent in the treatment of IS. In our study, As-IV promoted the transcription of fat mass and obesity-associated (Fto) by upregulating activating transcription factor 3(Atf3), resulting in a decrease of long-chain acyl-CoA synthetase-4 (Acsl4) N6-methyladenosine (m6A) levels, thus improving neuronal injury in IS by inhibiting ferroptosis. These findings provided a better understanding of the molecular mechanisms underlying the neuroprotective effects of As-IV and led to novel t...
Source: Journal of Neurochemistry - June 10, 2023 Category: Neuroscience Authors: Zhenglong Jin, Wenying Gao, Fu Guo, Shaojun Liao, Mingzhe Hu, Tao Yu, Shangzhen Yu, Qing Shi Tags: ORIGINAL ARTICLE Source Type: research

Bioinformatics ‐based analysis of mechanistic differences in vascular endothelial injury ischemic stroke induced by atrial fibrillation and atherosclerosis
This study aimed to investigate the mechanistic differences in endothelial injury between atrial fibrillation (AF)- and AS-induced ischemic stroke. All target genes of AF, AS, and the vascular endothelial cell (VC) were obtained from the GeneCards database; the differential genes of AF and AS separately associated with the VC were established by a Venn diagram. A protein –protein interaction network was created, and Gene Ontology and Kyoto Encyclopedia of Genes and Genomes databases were used to perform genomic enrichment and functional enrichment analysis. Hub genes were selected by Maximal Clique Centrality algorithm r...
Source: Journal of Neurochemistry - June 2, 2023 Category: Neuroscience Authors: Jia Li, Rui Yang, Shenglin Wang, Ziyi Shen, Bowen Wu, Yu Ren, Sha Ke, Guohui Jiang Tags: ORIGINAL ARTICLE Source Type: research

Astrocytic Chitinase ‐3‐like Protein 1 in Neurological Diseases: Potential Roles and Future Perspectives
AbstractChitinase-3-like protein 1 (CHI3L1) is a secreted glycoprotein characterized by its ability to regulate multiple biological processes, such as the inflammatory response and gene transcriptional signaling activation. Abnormal CHI3L1 expression has been associated with multiple neurological disorders and serves as a biomarker for the early detection of several neurodegenerative diseases. Aberrant CHI3L1 expression is also reportedly associated with brain tumor migration and metastasis, as well as contributions to immune escape, playing important roles in brain tumor progression. CHI3L1 is synthesized and secreted mai...
Source: Journal of Neurochemistry - April 7, 2023 Category: Neuroscience Authors: Fei Li, An Liu, Minggao Zhao, Lanxin Luo Tags: REVIEW Source Type: research

Ca2+ ‐dependent activator protein for secretion 1 promotes spontaneous recovery in ischemic stroke by regulating BDNF secretion
In conclusion, CAPS1 regulates neurogenesis by upregulating BDNF release in the hippocampus, which finally facilitate spontaneous recovery after ischemic stroke.
Source: Journal of Neurochemistry - March 15, 2023 Category: Neuroscience Authors: DianWei Liu, Yan Zheng, Yuan Chen, Yang Jiang, HuiYun Wang, LingMei Li, Ling Ma Tags: ORIGINAL ARTICLE Source Type: research

Iron, Ferroptosis, and Ischemic Stroke
AbstractOver 30 million people suffer from the consequences of ischemic stroke. The precise molecular mechanism of neuronal damage during ischemic stroke remains unclear; therefore, the effective treatment of post-ischemic stroke remains a critical challenge. Recently, iron has emerged as a crucial factor in post-reperfusion injuries, participating in cell peroxidation, excitotoxicity, and a distinctive cell death pathway, namely ferroptosis. Since iron is tightly regulated in the brain and important for brain functions, the imbalance of its metabolism, including its overload and deficiency, has been shown to impact ischem...
Source: Journal of Neurochemistry - March 13, 2023 Category: Neuroscience Authors: Jun Guo, Qing ‐zhang Tuo, Peng Lei Tags: REVIEW Source Type: research

Cerebrospinal fluid and blood profiles of transfer RNA fragments show age, sex, and Parkinson's disease ‐related changes
Transfer RNA fragments (tRFs) are important regulatory small RNAs with diverse functions. We studied age, sex, and Parkinson's disease (PD) effects on the distributions of tRFs in the cerebrospinal fluid (CSF) and blood, in NIH and PPMI datasets. We discovered that CSF tRFs were more variable in length and cleavage subtypes, negatively correlated with age and showed more pronounced differences between males and females than blood tRFs. Both CSF and blood tRFs differentiated PD patients from controls, based on distinct subsets of tRFs, both highly enriched with mitochondrial Cholino-tRFs. Our findings point at tRFs as a pro...
Source: Journal of Neurochemistry - November 23, 2022 Category: Neuroscience Authors: Iddo Paldor, Nimrod Madrer, Shani Vaknine Treidel, Dana Shulman, David S. Greenberg, Hermona Soreq Tags: ORIGINAL ARTICLE Source Type: research

Cerebrospinal fluid and blood profiles of transfer RNA fragments show age, sex and Parkinson's disease ‐related changes
AbstractTransfer RNA fragments (tRFs) have recently been shown to be an important family of small regulatory RNAs with diverse functions. Recent reports have revealed modified tRF blood levels in a number of nervous system conditions including epilepsy, ischemic stroke and neurodegenerative diseases, but little is known about tRF levels in the cerebrospinal fluid (CSF). To address this issue, we studied age, sex and Parkinson's disease (PD) effects on the distributions of tRFs in the CSF and blood data of healthy controls and PD patients from the NIH and the Parkinson's Progression Markers Initiative (PPMI) small RNA-seq d...
Source: Journal of Neurochemistry - November 11, 2022 Category: Neuroscience Authors: Iddo Paldor, Nimrod Madrer, Shani Vaknine Treidel, Dana Shulman, David S. Greenberg, Hermona Soreq Tags: ORIGINAL ARTICLE Source Type: research

Inhibition of interaction between ROCK1 and Rubicon restores autophagy in endothelial cells and attenuates brain injury after prolonged ischemia
AbstractAbstractAcute ischemic stroke (AIS) induces cerebral endothelial cells death resulting in the breakdown of blood-brain barrier (BBB). Endothelial cells autophagy acts as a protective mechanism against cell death. Autophagy is activated in the very early stages of ischemic stroke and declines after prolonged ischemia. Previous studies have shown that Rubicon can inhibit autophagy. The current study aimed to investigate whether continuous long-term ischemia can inhibit autophagy in endothelial cells after ischemic stroke by regulating the function of Rubicon and its underlying mechanism.Wild-type male C57BL/6J mice w...
Source: Journal of Neurochemistry - November 6, 2022 Category: Neuroscience Authors: Yinyao Lin, Zexin Zhan, Mengyan Hu, Haiyan Li, Bingjun Zhang, Ruizhen Wu, Sha Tan, Yilong Shan, Zhengqi Lu, Bing Qin Tags: ORIGINAL ARTICLE Source Type: research

LncRNA nuclear ‐enriched abundant transcript 1 aggravates cerebral ischemia/reperfusion injury through activating early growth response‐1/RNA binding motif protein 25 axis
In conclusion, this work identified a novel NEAT1/EGR1/RBM25 axis in potentiating brain injury after IR insults, suggesting a potential therapeutic target for ischemic stroke.
Source: Journal of Neurochemistry - August 23, 2022 Category: Neuroscience Authors: Jing ‐Wei Cao, Zhan‐Bin Tang, Ji‐Wei Zhao, Jing‐Kun Zhao, Jia‐Lin Yao, Xiao‐Meng Sheng, Mian‐Qiao Zhao, Qiong Duan, Bai‐Chao Han, Shu‐Rong Duan Tags: ORIGINAL ARTICLE Source Type: research

Circulating metabolites associated with incident myocardial infarction and stroke: a prospective cohort study of 90,438 participants
AbstractThe relevance between circulating metabolites and vascular events remains controversial and comprehensive studies are lacking. We sought to investigate the prospective associations of plasma metabolomics with risks of incident stroke, ischemic stroke (IS), hemorrhagic stroke (HS) and myocardial infarction (MI). Within the UK Biobank cohort, 249 circulating metabolites were measured in 90,438 participants without baseline vascular diseases. Cox proportional hazards regressions were applied to estimate adjusted hazard ratios (HRs) for per 1 standard deviation increment in metabolites. The least absolute shrinkage and...
Source: Journal of Neurochemistry - June 28, 2022 Category: Neuroscience Authors: Yu Guo, Shu ‐Fen Chen, Ya‐Ru Zhang, Hui‐Fu Wang, Shu‐Yi Huang, Shi‐Dong Chen, Yue‐Ting Deng, Bang‐Sheng Wu, Kevin Kuo, Rong‐Ze Wang, Qiang Dong, Jian‐Feng Feng, Wei Cheng, Jin‐Tai Yu Tags: ORIGINAL ARTICLE Source Type: research

Antimicrobial Protein REG3A and Signaling Networks are Predictive of Stroke Outcomes
AbstractRegenerating Family Member 3 Alpha (REG3A) is a multifunctional protein with antimicrobial activity, and primarily secreted by the intestine and pancreas. Studies have shown an increased expression of REG3A in systemic inflammatory responses to acute injury and infection, but studies investigating REG3A during the pathogenesis of ischemic stroke are limited. The aims of this study were to examine the associations between arterial expression of REG3A and other arterial inflammatory proteins implicated in stroke pathogenesis, as well as associations between REG3A and markers of poor outcome for ischemic stroke. The U...
Source: Journal of Neurochemistry - September 24, 2021 Category: Neuroscience Authors: Madison Sands, Jacqueline A. Frank, Benton Maglinger, Christopher J. McLouth, Amanda L. Trout, Jadwiga Turchan ‐Cholewo, Ann M. Stowe, Justin F. Fraser, Keith R. Pennypacker Tags: ORIGINAL ARTICLE Source Type: research

Targeting focal ischemic and hemorrhagic stroke neuroprotection: current prospects for local hypothermia
AbstractTherapeutic hypothermia (TH) has applications dating back millennia. In modern history, however, TH saw its importation into medical practice where investigations have demonstrated that TH is efficacious in ischemic insults, notably cardiac arrest and hypoxic-ischemic encephalopathy. As well, studies have been undertaken to investigate whether TH can provide benefit in focal stroke (i.e., focal ischemia and intracerebral hemorrhage). However, clinical studies have encountered various challenges with induction and maintenance of post-stroke TH. Most clinical studies have attempted to use body-wide cooling protocols,...
Source: Journal of Neurochemistry - September 9, 2021 Category: Neuroscience Authors: Lane J. Liddle, Anna C.J. Kalisvaart, Ashley H. Abrahart, Mohammed Almekhlafi, Andrew Demchuk, Frederick Colbourne Tags: REVIEW Source Type: research