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Ca2+ ‐dependent activator protein for secretion 1 promotes spontaneous recovery in ischemic stroke by regulating BDNF secretion
In conclusion, CAPS1 regulates neurogenesis by upregulating BDNF release in the hippocampus, which finally facilitate spontaneous recovery after ischemic stroke.
Source: Journal of Neurochemistry - March 15, 2023 Category: Neuroscience Authors: DianWei Liu, Yan Zheng, Yuan Chen, Yang Jiang, HuiYun Wang, LingMei Li, Ling Ma Tags: ORIGINAL ARTICLE Source Type: research

Issue Cover (March 2021)
Front cover:Necrostatin ‐1 (Nec‐1) has been shown to inhibit necroptosis. The mitochondrial protein Bcl‐2/adenovirus E1B 19‐kDa interacting protein 3 (BNIP3) activates a type of caspase‐independent cell death that is similar to necroptosis. Here we show that Nec‐1 is protective against death of neurons and olig odendrocytes in traumatic brain injury (TBI) in mice and in ischemic stroke in rats by inhibiting BNIP3; Nec‐1 prevents BNIP3 from integration into mitochondria to block the BNIP3 cell death pathway. The data suggest that Nec‐1 is a novel inhibitor for BNIP3.Image Content: Nec‐1 preserves structur...
Source: Journal of Neurochemistry - April 2, 2021 Category: Neuroscience Tags: Issue Cover Source Type: research