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Source: Journal of Stroke and Cerebrovascular Diseases
Condition: Ischemic Stroke
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Total 2464 results found since Jan 2013.
Infections Present on Admission Compared with Hospital-Acquired Infections in Acute Ischemic Stroke Patients
Background: To date, few studies have assessed the influence of infections present on admission (POA) compared with hospital-acquired infections (HAIs) on neurologic deterioration (ND) and other outcome measures in acute ischemic stroke (AIS).Methods: Patients admitted with AIS to our stroke center (July 2010 to December 2010) were retrospectively assessed. The following infections were assessed: urinary tract infection, pneumonia, and bacteremia. Additional chart review was performed to determine whether the infection was POA or HAI. We assessed the relationship between infections in ischemic stroke patients and several o...
Source: Journal of Stroke and Cerebrovascular Diseases - August 19, 2013 Category: Neurology Authors: Amelia K. Boehme, Andre D. Kumar, Adrianne M. Dorsey, James E. Siegler, Monica S. Aswani, Michael J. Lyerly, Dominique J. Monlezun, Alexander J. George, Karen C. Albright, Timothy M. Beasley, Sheryl Martin-Schild Tags: Original Articles Source Type: research
Race and Income Disparity in Ischemic Stroke Care: Nationwide Inpatient Sample Database, 2002 to 2008
We examined whether patients of particular ethnicity or income levels experienced reduced access to or delays in receiving stroke care.Methods: We studied all admissions for ischemic stroke in the Nationwide Inpatient Sample (NIS) database between 2002 and 2008. We used statistical models to determine whether median income or race were associated with intravenous (IV) thrombolysis treatment, in-hospital mortality, discharge disposition, hospital charges, and LOS in high- or low-volume hospitals.Results: There were a total of 477,474 patients with ischemic stroke: 10,781 (2.3%) received IV thrombolysis, and 380,400 (79.7%) ...
Source: Journal of Stroke and Cerebrovascular Diseases - July 23, 2012 Category: Neurology Authors: Matthew M. Kimball, Dan Neal, Michael F. Waters, Brian L. Hoh Tags: Original Articles Source Type: research
Tissue Plasminogen Activator Overdose in Acute Ischemic Stroke Patients Linked to Poorer Functional Outcomes
Conclusions: Our findings provide support for the practice of accurately weighing all acute ischemic stroke patients before thrombolysis.
Source: Journal of Stroke and Cerebrovascular Diseases - February 4, 2013 Category: Neurology Authors: Demetrios J. Sahlas, Linda Gould, Richard H. Swartz, Naufal Mohammed, Rhonda McNicoll-Whiteman, Fahd Naufal, Wieslaw Oczkowski Tags: Original Articles Source Type: research
Resistive Training Improves Insulin Sensitivity after Stroke
This study determined the effects of unilateral resistive training (RT) of both the paretic and nonparetic legs on insulin sensitivity in stroke survivors.Methods: We studied 10 participants (mean age 65 ± 2 years; mean body mass index 27 ± 4 kg/m2) with hemiparetic gait after remote (>6 months) ischemic stroke. All subjects underwent 1-repetition maximum (1-RM) strength testing, 9 had an oral glucose tolerance test (OGTT), and 7 completed a 2-hour hyperglycemic clamp (with glucose elevation targeted at 98 mg/dL above baseline fasting level) before and after 12 weeks (3×/week) of progressive, high repetition, high-i...
Source: Journal of Stroke and Cerebrovascular Diseases - January 24, 2013 Category: Neurology Authors: Frederick M. Ivey, Alice S. Ryan Tags: Original Articles Source Type: research
Prognostic Value of High-sensitivity Cardiac Troponin T in Acute Ischemic Stroke
Background: Cardiac troponins have been investigated as prognostic markers in the setting of ischemic stroke with diverging results. A new generation of highly sensitive troponin assays have recently been developed that allow for the detection of concentrations 5 to 10 times lower than those measureable with conventional assays. The aim of this study was to determine the association between high-sensitivity cardiac troponin T (hs-cTnT) elevation on admission and mortality after acute ischemic stroke.Methods: Serum concentrations of hs-cTnT were measured at the time of admission in 347 patients with acute ischemic stroke. C...
Source: Journal of Stroke and Cerebrovascular Diseases - February 11, 2013 Category: Neurology Authors: Kashif Waqar Faiz, Bente Thommessen, Gunnar Einvik, Torbjørn Omland, Ole Morten Rønning Tags: Original Articles Source Type: research
Thrombolysis for Acute Ischemic Stroke: Do Patients Treated Out of Hours Have a Worse Outcome?
Introduction: Previous studies on the impact of nonworking hours (NWH) have produced conflicting results. We aimed to compare the time to treatment with thrombolysis between NWH and working hours (WH) at an Australian comprehensive stroke center.Materials and Methods: All acute ischemic stroke patients treated with intravenous alteplase (IV-alteplase) from January 2003 to December 2011 at the Royal Melbourne Hospital were included. Data collected included demographics, serial time points (including onset, presentation to emergency department, neuroimaging, and thrombolysis), and clinical outcomes (modified Rankin Scale [mR...
Source: Journal of Stroke and Cerebrovascular Diseases - April 30, 2013 Category: Neurology Authors: Kun Fang, Leonid Churilov, Louise Weir, Qiang Dong, Stephen Davis, Bernard Yan Tags: Original Articles Source Type: research
Long-term Adherence to National Guidelines for Secondary Prevention of Ischemic Stroke: A Prospective Cohort Study in a Public Hospital in Chile
Conclusions: The observed significant decrease in adherence to oral anticoagulation in patients with cardioembolic stroke suggests a need for the implementation of specific strategies to achieve the desired secondary prevention goals in these patients. Future research into the evaluation of other factors that could be associated with the lack of adherence to these guidelines, measurements of therapeutic goals, and new therapeutic strategies that are easier to use and that are associated with less risk could improve the prognosis of these patients.
Source: Journal of Stroke and Cerebrovascular Diseases - May 15, 2013 Category: Neurology Authors: Paula Muñoz-Venturelli, Claudio Sacks, Eva Madrid, Pablo M. Lavados Tags: Original Articles Source Type: research
The Role of Classic Risk Factors and Prothrombotic Factor Gene Mutations in Ischemic Stroke Risk Development in Young and Middle-Aged Individuals
Background: In young individuals, a genetically predisposing hypercoagulability and classic modifying risk factors can act synergistically on the ischemic stroke risk development. The aim of the study was to compare the prevalence of classic vascular risk factors and polymorphisms of the G20210A coagulation factor II (prothrombin), Arg506Glu coagulation factor V Leiden, C677T methylenetetrahydrofolate reductase (MTHFR), and 4G/5G plasminogen activator inhibitor-1 (PAI-1) and the impact of these gene mutations and classic vascular risk factors on the overall stroke risk in individuals aged 55 years or younger.Methods: The s...
Source: Journal of Stroke and Cerebrovascular Diseases - November 4, 2013 Category: Neurology Authors: Visnja Supanc, Zdenko Sonicki, Ines Vukasovic, Vesna V. Solter, Iris Zavoreo, Vanja B. Kes Tags: Original Articles Source Type: research
Dilemma of Indication for Thrombolysis in a Patient with Acute Ischemic Stroke Treated with a Novel Oral Anticoagulant
We report the case of a patient treated with dabigatran who developed acute ischemic stroke and was considered for thrombolysis. Because of the prolonged thrombin time (TT), thrombolysis was not performed. Repeated coagulation tests 5 days after stroke, with unchanged anticoagulant (dabigatran) treatment, found 2-fold higher TT and activated partial thromboplastin time (APTT) compared with the values found in the acute stage. Routine coagulation tests (TT and APTT) do not reliably reflect the coagulation features of a patient; therefore, there is an urgent need to develop reliable biomarkers and an adequate guideline to ...
Source: Journal of Stroke and Cerebrovascular Diseases - May 30, 2013 Category: Neurology Authors: András Folyovich, Viktória Varga, Katalin A. Béres-Molnár, Károly Vadasdi, Dániel Bereczki Tags: Case Reports Source Type: research
Cardiovascular Health Status and Metabolic Syndrome in Ecuadorian Natives/Mestizos Aged 40 Years or More with and without Stroke and Ischemic Heart Disease—An Atahualpa Project Case–Control Nested Study
Conclusions: This case–control study suggests that none of the measured risk factors is associated with the occurrence of vascular events. It is possible that some yet unmeasured risk factors or an unknown genetic predisposition may account for a sizable proportion of stroke and ischemic heart disease occurring in the native/mestizo population of rural coastal Ecuador.
Source: Journal of Stroke and Cerebrovascular Diseases - July 8, 2013 Category: Neurology Authors: Oscar H. Del Brutto, Robertino M. Mera, Martha Montalván, Victor J. Del Brutto, Mauricio Zambrano, Milton Santamaría, Daniel Tettamanti Tags: Original Articles Source Type: research
Adult Height and Body Mass Index in Relation to Risk of Total Stroke and its Subtypes: The Circulatory Risk in Communities Study
Background: Several studies have reported that height and risk of stroke are inversely associated based on the hypothesis that height is a marker of childhood physical condition. However, a limited number of studies have taken account of the effect of current physical condition on the relationship between height and risk of stroke.Methods: We conducted a prospective cohort study of 12,222 40- to 69-year-old Japanese patients under systematic surveillance for stroke incidence. Because body mass index (BMI) is regarded as a surrogate marker of current physical condition for cardiovascular risk, we performed a stratified anal...
Source: Journal of Stroke and Cerebrovascular Diseases - July 19, 2013 Category: Neurology Authors: Yuji Shimizu, Hironori Imano, Tetsuya Ohira, Akihiko Kitamura, Masahiko Kiyama, Takeo Okada, Yoshinori Ishikawa, Takashi Shimamoto, Kazumasa Yamagishi, Takeshi Tanigawa, Hiroyasu Iso, CIRCS Investigators Tags: Original Articles Source Type: research
Evaluating Middle Cerebral Artery Atherosclerotic Lesions in Acute Ischemic Stroke Using Magnetic Resonance T1-weighted 3-Dimensional Vessel Wall Imaging
Background: Atherosclerotic lesions in intracranial arteries are a leading cause of ischemic stroke. Magnetic resonance angiography (MRA) is often used to assess atherosclerotic changes by detecting luminal narrowing, whereas it cannot directly visualize atherosclerotic lesions. Here, we used a 3-dimensional vessel wall imaging (3D-VWI) technique to evaluate intracranial arterial wall changes in acute stroke.Methods: Eighteen consecutive patients with acute noncardioembolic stroke in the middle cerebral artery (MCA) territory who were prospectively examined with a 1.5-T magnetic resonance scanner were studied. T1-weighted ...
Source: Journal of Stroke and Cerebrovascular Diseases - July 22, 2013 Category: Neurology Authors: Tatsunori Natori, Makoto Sasaki, Mitsuharu Miyoshi, Hideki Ohba, Noriyuki Katsura, Mao Yamaguchi, Shinsuke Narumi, Hiroyuki Kabasawa, Kohsuke Kudo, Kenji Ito, Yasuo Terayama Tags: Original Articles Source Type: research
Factors Associated with Proximal Carotid Axis Occlusion in Patients with Acute Stroke and Atrial Fibrillation
Conclusions: Female sex, advanced age, history of systemic embolism, and higher BNP level were independently associated with more proximal carotid axis occlusion. Patients with AF having these factors may be prone to have relatively large thrombi in the heart.
Source: Journal of Stroke and Cerebrovascular Diseases - October 7, 2013 Category: Neurology Authors: Yuki Sakamoto, Shoichiro Sato, Yuka Kuronuma, Kazuyuki Nagatsuka, Kazuo Minematsu, Kazunori Toyoda Tags: Original Articles Source Type: research
Stroke Mimics under the Drip-and-Ship Paradigm
Conclusion: The drip-and-ship paradigm and any psychiatric history predict the diagnosis of SM. None of the SM had thrombolysis-related complications, and all were discharged to home. These findings may explain the superior outcomes associated with the drip-and-ship paradigm in the treatment for AIS.
Source: Journal of Stroke and Cerebrovascular Diseases - August 19, 2013 Category: Neurology Authors: Sonal Mehta, Nirav Vora, Randall C. Edgell, Hesham Allam, Aws Alawi, Jennifer Koehne, Abhay Kumar, Eliahu Feen, Salvador Cruz-Flores, Amer Alshekhlee Tags: Original Articles Source Type: research
Socioeconomic Disparities in the Utilization of Mechanical Thrombectomy for Acute Ischemic Stroke
We examined the utilization rates of mechanical thrombectomy by race/ethnicity (white, black, Hispanic, and Asian/Pacific Islander), income quartile (first, second to third, and fourth), and insurance status (Medicare, Medicaid, self-pay, and private). We also studied thrombectomy utilization rates at hospitals that performed thrombectomy.Results: From 2006 to 2010, 2,087,017 patients were hospitalized with a primary diagnosis of acute ischemic stroke; 8946 patients (.4%) received mechanical thrombectomy. Compared with white patients, black patients had significantly lower rates of overall mechanical thrombectomy utilizati...
Source: Journal of Stroke and Cerebrovascular Diseases - October 10, 2013 Category: Neurology Authors: Waleed Brinjikji, Alejandro A. Rabinstein, Harry J. Cloft Tags: Original Articles Source Type: research
